Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2246 for “"Translational"”.
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Translational Architecture
… construction. This process can be described as translational architecture. The act of translation does not consist merely of mimicry but a transformation into something similar yet substantively different. This act of translation disrupts the implicit superiority of the original because the …
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Translational design computation
… thesis introduces, demonstrates and implements translational design computation: a theoretical approach and technical framework for mediating living and nonliving matter through design computation. I propose that computational design can act as a "language" for the enablement of design at the …
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Translational design computation
Synergetic tensions have evolved the dichotomy between the physical and digital design domains into a symbiotic unity. New capabilities in digital fabrication give rise to sophisticated tools of computational design, while new affordances in computational design inspire innovation in digital …
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Mechanisms of Translational Control
… to investigate the fundamental mechanisms of translational control in ribosomes. Specifically, we examine the molecular basis of Sec stop codon suppression and insertion, as well as the phenotypic consequences of perturbations to this process. Additionally, we explore how ribosome-binding …
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TRANSLATIONAL RESEARCH TARGETING BILIARY TRACT CANCER
… (CCA) and gallbladder cancer (GBC). In this translational research program targeting BTC, we focus on three aspects: the development of a combination treatment against CCA, the exploration of the immune background of GBC, and the establishment of a CCA mouse model mimicking mutation profiles …
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A HYBRID APPROACH FOR TRANSLATIONAL RESEARCH
Translational research has proven to be a powerful process that bridges the gap between basic science and medical practice. The complexity of translational research is two-fold: integration of vast amount of information in disparate silos, and dissemination of discoveries to stakeholders with …
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Translational Incorporation of Unsaturated Amino Acids
… lysate from E.coli is a common source of translational machinery for in vitro protein synthesis and has been shown to remove many commonly encountered protecting groups from α- amino acids. A chemically intractable unnatural amino acid has been supplied to this cellular extract and its …
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Translational Incorporation of Unsaturated Amino Acids
… lysate from E.coli is a common source of translational machinery for in vitro protein synthesis and has been shown to remove many commonly encountered protecting groups from α- amino acids. A chemically intractable unnatural amino acid has been supplied to this cellular extract and its …
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Finite Element Analysis of Translational Shells
Made available in DSpace on 2014-12-10T22:21:35Z (GMT). No. of bitstreams: 1 7121092.pdf: 3127589 bytes, checksum: 4722fbf5beafdd49ab74bc3edee15161 (MD5) Previous issue date: 1971
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RNA regulatory elements and translational control
… to establish an infection. In this work, the translational landscape of *Salmonella* Typhimurium and *Listeria monocytogenes* was analysed using a ribosome profiling method adapted for examination of bacteria which yielded single-nucleotide-resolution data. The ribosome profiles in combination …
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FDG-PET in Cervical Cancer - Translational Studies
Cervical cancer is the second most common cancer in females. The treatment, based on clinical FIGO stage, carries a significant risk of side effects. FDG-PET enables non-invasive studies of glucose metabolism. Cancer cells show an increased glucose uptake and metabolism that can be visualised and …
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Translational Modeling of Non-Invasive Electrical Stimulation
<p>Seminal work in the early 2000’s demonstrated the effect of low amplitude non-invasive electrical stimulation in people using neurophysiological measures (motor evoked potentials, MEPs). Clinical applications of transcranial Direct Current Stimulation (tDCS) have since proliferated, though the …
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Translational regulation in aggressive B-cell lymphomas
… precision. Here I investigate the mechanisms of translational regulation contributing to lymphoma development. Firstly, I introduce RiboStream, an automated bioinformatic pipeline designed to streamline processing of Ribo-Seq datasets while maintaining transparency and reproducibility of the …
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Engineering phosphorylation-dependent post-translational protein devices
… I developed a framework for engineering post-translational devices, which are devices whose inner workings are modulated by non-covalent protein interactions and covalent protein modifications. To test the framework, I designed a scaffold for engineering post-translational devices in yeast, …
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Determinants of translational efficiency in Saccharomyces cerevisiae
… is to elucidate the mechanisms that govern translational efficiency (TE) - the amount of protein produced from each molecule of mRNA. While the mechanisms regulating the TE of a few specific messages are well understood, the general contribution of translational control to differences in …
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Post-translational phosphorylation dynamics in Arabidopsis and Physcomitrella
Phosphorylation is the most abundant post-translational modification that involves the chemical addition of a phosphate group onto serine, threonine, or tyrosine residues of substrate proteins. Phosphorylation is utilized to regulate protein activity, stability, or localization to respond to …
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7-DOF Robotic Arm XY-Plane Translational Stability
… this thesis is to focus on the two-dimensional translational effects of an arm operating on a simulated zero-friction surface and provide a method to anticipate and stabilize these induced forces. By calculating the forces generated by the movement of a 7-DOF Sawyer robotic arm using the arm’s …
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Translational control mechanisms in the p53 response network
… networks p53 regulates. To investigate mRNA translational control as an additional dimension of p53-directed gene expression responses, we performed translatome analyses upon its activation either by different agents or cellular contexts. Considered as a proxy for the proteome, the …
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Translational Regulation of the C-Jun Proto-Oncogene
… dimerization, DNA binding and post-translational modification. I report here that the <em>c-jun</em> proto-oncogene can also be regulated at the translational level.</p>
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Translational Analysis of Extended Extinction Effects on Resurgence
Resurgence is the reemergence of a previously reinforced but not currently occurring behavior (e.g. problem behavior) in response to worsening conditions of reinforcement for current behavior (e.g. alternative behavior; Lattal, 2017). Understanding the extent to which resurgence of problem …
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