Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Translation dynamics"”.
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Representing translation: concepts, methods, and resources for protein coding loci representation and ribosome profiling data analysis
… life. The understanding of the extent to which translation occurs outside of annotated protein coding regions has been greatly expanded, as has the understanding of the role of translation dynamics in gene expression. As more and more Ribo-Seq data is made available and consequently more …
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Expanding the applications of high-throughput DNA sequencing
… provides insight into the true signatures of translation dynamics in yeast and offers important guidance for the future design and interpretation of sequencing-based approaches to measuring these dynamics.
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Axonal Translation and Links to Neuropathies
… techniques to investigate Netrin-1-induced translation in cultured retinal axons. Total axonal protein synthesis measured by metabolic and puromycin labelling indicates axons experience stage-dependent alterations in translation rate upon Netrin-1 stimulation. Remarkably, Netrin-1 triggers a …
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Translational defects in multiple tissues from the Smn2B/- mouse model of SMA.
… that SMN deficiency also disrupts protein translation in vivo in a mouse model of severe SMA, complicating SMA's molecular landscape. This thesis examines the impact of SMN protein loss on translation in SMA mouse models across tissues, post-natal and pre-natal disease stages, focusing on …
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Regulatory mechanisms underlying C3 carbon and nitrogen metabolism under elevated CO2
… The first aim involves optimizing protein translation dynamics in C3 plants. It is essential to understand the processes underlying changes in protein abundance in a gene under varying physiological and developmental conditions to model and rationally engineer plants. Several protein …