Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Transient Interactions"”.
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Complex mechanical design of bio-inspired model transient network hydrogels
… significantly more difficult. Recently, transient interactions have been shown to vastly improve the mechanical properties of soft materials by providing increased energy dissipation through the dissociation of the reversible bonds. However, there is a wide variety of transient …
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Affinity-based Growth Factor Delivery from Injectable Hydrogels for Tissue Engineering
… An affinity-based system was developed whereby transient interactions between complementary binding partners were used to slow the diffusional release of a therapeutic from a polymeric delivery matrix. The Src homology 3 (SH3) domain, which binds a library of SH3-binding peptides, with varying …
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Dynamics of associative polymer networks
… that make up the network, as well as the transient interactions between them. Thus, elucidating the relationship between the molecular level details and the observed macroscopic properties is of high importance to further advance our understanding of associative networks. However, the …
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Intravital imaging of metastasis in zebrafish
… tumor cells are rare and are involved in many transient interactions adding to the challenge. The development of a line of zebrafish, Casper, that is transparent throughout its life suggested that zebrafish might be a powerful system for intravital imaging. I first developed novel injection and …
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Predicting motif mimicry in viruses
… the complex network of protein-protein interactions (PPI) that underpin biological processes. Two major classes of PPI are domain-domain interactions (DDI) between globular proteins, and domain-motif interactions (DMI) between a globular domain and a short linear motif (SLiM) in its …
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A lumped-parameter model of tire-terrain interactions for off-road vehicles
… lumped-parameter, physical model for capturing transient interactions between a deformable tire and a deformable terrain. Specifically, the model accounts for the radial and the tangential deformation in the tire as well as the normal and the tangential deformation of terrain. Furthermore, the …
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Network Dynamics of Visual Object Recognition
… EEG (icEEG) recordings to study rapid, transient interactions between the disseminated cortical substrates within category-specific networks. Employing novel techniques for the topologically accurate and statistically robust analysis of grouped icEEG, we found that category-selective …
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Principles of COPII Coat Assembly
… fusion. An interface generated through multiple transient interactions highlights the capacity for their utilisation by sequence-divergent proteins to compete with the coat components during coat regulation, or to achieve its efficient disassembly. The proposed type of combinatorial interface …
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Regulation of synaptic structure and function at the Drosophila neuromuscular junction
… that SNX16-positive early endosomes undergo transient interactions with Nwkcontaining recycling endosomes. We identify an alternative signal termination pathway in the absence of Snx16 that is controlled by ESCRT-mediated internalization of receptors into the endosomal lumen. Our results …
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Characterisation of the structure and function of the Salmonella flagellar export gate protein, FlhB.
… dissociation constants (5-45 μM), suggesting transient interactions. There was no clear correlation between subunit affinity for FlhB and the order of subunit assembly in the nascent flagellum. Solution-state nuclear magnetic resonance (NMR) spectroscopy supported prior data showing that rod …
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Molecular Size and Charge Effects on Nucleocytoplasmic Transport Studied By Single-Molecule Microscopy
… important selection criterion. The hydrophobic interactions between the FG-barrier and transport receptors are believed to be the essential process for transport receptor-facilitated translocation through the NPCs. However, it is still unknown whether only the hydrophobic surface of a cargo …
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Development of biomimetic microfluidic adhesive substrates for cell separation
… substrates for microfluidic devices involving transient interactions between the cells and the receptor-patterned substrates. How cells flow and get captured by patterned biomimetic substrates inside the microfluidic channels, how substrates parameters affect cell rolling trajectories and …
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Single molecule study of weak and transient biological interactions
… adaptation now allows the study of weakly and transiently interacting biomolecules at the single-molecule resolution. Here we present unique interactions between proteins and nucleic acids which were previously unattainable with conventional single molecule techniques.
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Exploring the Function of Cytochrome c6A
… mechanism of action, the localisation and interactions of c6A were studied. Using subcellular fractionation and immunofluorescence microscopy c6A was found in the thylakoid lumen. Co-immunoprecipitation studies did not reveal any stable complexes, consistent with a function for c6A through …
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Quantitative Deubiquitinase (DUB) Interactomics to Dissect the Biology of Cancer Associated DUBs
… of DUB substrates is challenging due to transient interactions between DUB and its substrate. In some cases, the substrates are rapidly degraded making it difficult to capture the DUB substrate interaction. Therefore, I proposed a strategy to identify substrates of USP25, whose substrates …
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Characterization of the p23 interaction network
… proteome. Through their broad binding capacity, transient interactions, and high cellular abundance, the Hsp70 and Hsp90 chaperone families promote folding of a diverse clientele in numerous cellular compartments and organelles. An often-underappreciated aspect of this activity is the ability to …