Global ETD Search
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Showing 1 to 20 of 42 for “"Transglutaminase"”.
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Nanocomposite immunosensor for anti-transglutaminase antibody
… in their blood. Thus, the concentration of anti-transglutaminase antibody (anti-tTG) in human sera is an important analytical marker for the diagnosis of CD. An immunosensor is a type of biosensor that has an antigen or antibody fragment as its biological recognition component. The specificity of …
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The interaction of angiocidin and tissue transglutaminase
… cell-extracellular matrix interactions. Tissue transglutaminase is ubiquitously expressed in various tissue types, occurs in both an intracellular and extracellular form, and is highly expressed in endothelial cells and smooth muscle cells in the vasculature. Tissue transglutaminase is secreted …
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One click closer to understanding transglutaminase 2
Contains fulltext : 102348.pdf (Publisher’s version ) (Open Access)
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Tissue Transglutaminase And Its Role In Human Cancer Progression
Tissue transglutaminase (tTG) is a protein-crosslinking enzyme whose expression is up-regulated in several human cancers. Here I show that tTG is a key participant in a novel EGFR/Src-signaling pathway and a potential target for inhibiting EGFR-promoted tumor progression. Specifically, EGF …
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Effects of organophosphates on neural and purified liver tissue transglutaminase
Transglutaminase 2 (TGase 2) is a multifunctional calcium dependent enzyme that catalyzes protein modifications. TGase 2 is essential in neuronal cell differentiation and it has been reported that certain organophosphates are able to inhibit this process, and the organophosphate phenyl saligenin …
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Significance of Increased Tissue Transglutaminase In Hormone Refractory Prostate Cancer
… for improved clinical outcomes.</p> <p>Tissue transglutaminase (TG2) is a multifunctional pro-inflammatory protein involved in diverse physiological processes such as inflammation, tissue repair, and wound healing. Its expression is also implicated in pathological conditions such as cancer and …
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Transglutaminase and peptidylarginine deiminase in the pathogenesis of autoimmune diseases
… autoimmune disorders. In CD, antibodies against transglutaminase 2 (TG2) and specific glutamine residues of gliadins have been identified. A similar situation is seen in rheumatoid arthritis with both anticitrullinated protein antibodies (ACPA) and auto-antibodies against the citrullinating …
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Regulation of Transglutaminase by 5-HT2A Receptor Signaling and Calmodulin
<p>Transglutaminase (TGase), nature’s biological glue, catalyzes the post-translational modification of proteins by formation of intra- and intermolecular protein cross-links or by primary amine incorporation. TGase has various physiological functions, such as skin-barrier formation and blood clot …
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The isolation and characterisation of Transglutaminase 2 inhibitors from natural sources
Transglutaminases are calcium dependent enzymes which are involved in a variety of human disease conditions. Nine different isotypes of transglutaminases have been described including transglutaminase 2 (TG2) which is the most well characterised isotype. Transglutaminases possess a range of …
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Transglutaminase in the life and death of the pancreatic β-cell
Tissue transglutaminase (TG2) is a ubiquitous enzyme that catalyses both the Ca2+-dependent formation of protein cross-links via intermolecular isopeptide bonds, and the Ca2+-independent hydrolysis of GTP. The multifunctional nature of the TG2 protein has been reported in numerous intracellular …
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Syndecan-4 regulates cell-surface trafficking and biological activity of transglutaminase-2
Transglutaminase-2 (TG2) is a Ca2+-dependent crosslinking enzyme involved in the post-translational modification of proteins via the formation of Nε(γ-glutamyl)lysine isodipeptides. TG2 is externalised in the extracellular matrix (ECM) through an unconventional and not fully understood pathway. …
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Mechanism of tissue transglutaminase upregulation and its role in ovarian cancer metastasis
… Our laboratory previously reported that tissue transglutaminase (TG2) is overexpressed in OC and enhances OC peritoneal metastasis. TG2 is a multifunctional protein which catalyzes Ca2+-dependent cross-linking of proteins. The purpose of this study was to explore the mechanism by which TG2 is …
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Caseins micelles crosslinked with transglutaminase: foaming properties as a function of pH
… In this context, enzymatic crosslinking with transglutaminase (Tgase) can increase the stability of CMs against pH collapse. This work imitially does a review on foam structure and the main factors influencing the CMs structure and 1ts relation to foam stabihty. In addition, it approaches how …
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Influence of climate changes on cross allergies: possible involvement of pollen transglutaminase
… the underlying mechanism is little understood. Transglutaminases (TGases), a class of enzymes able to post-translationally modify proteins, are activated under stress and involved in some inflammatory responses, enhancing the activity of pro-inflammatory phospholipase A2, suggesting a role in …
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Design, Synthesis and Evaluation of Covalent Inhibitors for Tissue Transglutaminase and Factor XIIIa
Transglutaminases are a family of enzymes expressed in various tissues of our body. Some are expressed ubiquitously while others are specific to a tissue. Their primary catalytic activity is to crosslink substrates via an isopeptidic bond. The work described in this thesis focuses on two of these …
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Stability of microbial transglutaminase and its reactions with individual caseins under atmospheric and high pressure
Kinetic inactivation of factor XIIIa and MTG were performed in a pressure range from 0.1 to 400 MPa at 40°C within a time from 0 to 60 min in a TRIS-acetate buffer at pH 6.0. The inactivation of both enzymes at these conditions followed a first order reaction model. The high inactivation rate …
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The importance of the tissue transglutaminase-fibronectin heterocomplex in the RGD-independent cell adhesion and fibronectin matrix deposition
Tissue transglutaminase (TG2) has been reported as a wound response protein. Once over-expressed by cells under stress such as during wound healing or following tissue damage, TG2 can be secreted and deposited into extracellular matrix, where it forms a heterocomplex (TG-FN) with the abundant …
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Cell attachment to Zein surfaces
… substrate surfaces is often mediated by tissue transglutaminase (tTG) in its role as a crosslinking enzyme. Zein, a corn protein, has been recently studied as a biocompatible material in tissue engineering. It is a prolamin containing multiple poly-glutamine strands. Previous studies suggested …
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Plant protein structure design and its potential substitution of dairy proteins in gelation systems
… gels treated with by heating and microbial transglutaminase. The studies focused on the influence of different pH levels on the structural, surface properties and functional properties of different plant proteins and dairy proteins. Findings demonstrated that dairy proteins generally showed …
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Production of Restructured Squid and Scallops from Processing By-Products and Underutilized Species
… from cold-set binders: alginate and microbial transglutaminase at the 1% level with different setting times to yield the highest binding strength. At the setting temperature of 5° C, restructured scallops bound with alginate presented the greatest binding strength at 2 hr setting, while those …
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