Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Transgenic rats"”.
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HIV-1 Transgenic Rats Display Alterations in Immunophenotype and Cellular Responses Associated with Aging
… process of aging in mammalian species, including rats, results in changes with immune response, immunological phenotypes, and ultimately, increased susceptibility to many infectious diseases. In order to investigate the immunological pathologies associated with chronic HIV-1 disease, particularly …
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Functional genomics in the stroke-prone spontaneously hypertensive rat: genome wide and candidate gene analysis
… Wistar Kyoto (WKY) and chromosome 2 congenic rats identified differential expression of several glutathione cycling genes. The Gstm1 promoter was investigated by luciferase and Transfac bioinformatic analysis, implicating two polymorphism clusters and several transcription factors in reduced …
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Functionally non-adaptive retinal plasticity in rat models of human retinal degenerative disease
… its functional correlates were examined in RCS rats and transgenic rats which express a rhodopsin mutation; however, immunohistological work targeted one specific line (S334ter-4). Collectively, these studies provide evidence that supports the retinal adaptation model. These studies also provide …
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A Novel Transgenic Rat Model for the Study of Germ Cell Biology
… be very difficult. In an attempt to generate a transgenic line of rats expressing GFP in all cells of the body, a serendipitous integration of a ROSA-EGFP transgene resulted in exclusive expression of EGFP in the germ cells of both sexes. EGFP expression was uniform and robust in cleavage stage …
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Developmental Resilience to Dopaminergic Vulnerability Associated With Human Immunodeficiency Virus
… may be mounted by the CNS. Periadolescent HIV-1 transgenic rats were confronted with a dopamine challenge, following which mesencephalic tissues were assayed to determine changes in the expression of biomarkers vital to dopamine neurotransmission. In assaying inherent differences between control …
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Modelling fragile X syndrome in rats: new directions in translational research
… for FXS (Fmr1 KO rat). I showed that Fmr1 KO rats exhibit normal spatial navigation memory, social interactions and anxiety levels. On the contrary, when subjects were tested in a battery of spontaneous exploration tasks: object recognition (OR), object-context (OC), object-place (OP), and …