Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Transgenic mouse models"”.
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Characterisation of transgenic mouse models of Alzheimer's disease
A number of transgenic mouse models have been developed to study the molecular and pathological alterations associated with Alzheimer’s disease (AD). The 3xTg mouse is widely used as a research tool and carries mutations in the amyloid precursor protein (Swedish APP K670N/M671L), presenilin 1 …
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Development of inducible transgenic mouse models for melanoma
… the purpose of this project was to establish a transgenic mouse model able to investigate the molecular mechanism(s) of melanoma aetiology mediated by N-Ras and PTEN genes. To achieve this, an inducible gene switch approach was employed exploiting the Cre/loxP recombinase system. This approach …
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Creation and establishment of transgenic mouse models for for Mecp2 gene, causing Rett syndrome
Das MeCP2 Protein ist ein transkriptonaler Repressor, der an methylierte Cytosine bindet und die Chromatinstruktur modifiziert. Mecp2 ist für 95% aller Rett-Syndrom-Fälle verantwortlich. Trotz der ubiquitären Expression von MeCP2 wird angenommen, dass es einzigartige Funktionen in Neuronen hat. …
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Phenotyping Double Transgenic Mouse Models of Alzheimer’s that Express Human APP and ApoE3 or ApoE4
… associated with a high risk for developing AD). Transgenic mouse models of AD are commonly used to study the neuropathological processes behind the development of Aβ plaques, neurodegeneration, and associated behavioral deficits. The current study was designed to determine whether expression of …
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The development of peptide-based inhibitors of the low affinity Fc receptor, Fc [gamma] RIIa
… events. There is now strong evidence from transgenic mouse models and human genetic susceptibility studies that implicate FcyRIIa in a number of immune diseases including, rheumatoid arthritis, systemic lupus erythematosus (SLE) and immune thrombocytopenia purpura (ITP). FcyRHa is therefore …
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Vascular changes in Alzheimer’s disease and other types of dementia in the retina of human and animal
… Aβ within the retina of AD individuals and transgenic mouse models of AD, and to explore if an association exists between Aβ and retinal vasculature. Aβ accumulations were identified in flat-mount retina and cross-sections from AD and age-matched control eyes. Aβ labelling was found in …
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Development and characterization of novel transgenic techniques for the study of neuronal circuitry
… cells with precise spatial and temporal control. Transgenic mouse models, for example, can be used to manipulate cellular activity in order to draw conclusions about the molecular events responsible for the development, maintenance and refinement of healthy and/or diseased neuronal circuits. …
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Investigating the cytoplasmic role of E2F4 in multiciliogenesis
… proliferation and terminal differentiation. Transgenic mouse models have established that E2F4 is necessary for multiciliogenesis in the airway epithelia. Here we show that E2F4 plays two distinct roles in multiciliogenesis. In early stages, it functions in the nucleus to transcriptionally …
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Preclinical Evaluation of Matrix Metalloproteinase Inhibitors and Protein Kinase C Activators in Cell and Mouse Models of Huntington’s Disease
… established compounds and their effect in HD mouse striatal cells, human neural stem cells, and transgenic mouse models. We have evaluated three MMP inhibitor compounds and found one that crosses the blood brain barrier and as predicted inhibits gelatinases. We have also found the PKC …
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Factors contributing to T cell persistence in a tolerizing tumor environment
… ineffective through tolerance. Yet in various mouse models and human patients, tolerant T cells persist. The aim of this project is to identify factors that support T cell persistence in a tolerizing tumor environment. Using a spontaneous prostate cancer model, we study antigen-specific T cells …
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DISSECTING THE ROLE OF Β-CATENIN AND MYC IN GASTRIC TUMOR FORMATION
… remains elusive. Here, using conditional transgenic mouse models, we show that Wnt constitutive activation does not have any oncogenic effect in the gastric epithelium and cooperates with MYC in driving gastric tumorigenesis. By integrating transcriptomic and epigenomic analysis with …
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Prion protein in health and disease
… We deleted PrP from several well established transgenic mouse models of neurodegenerative disease, including Tauopathy, Parkinson's and Huntington's diseases. Deleting PrP did not substantially alter the disease phenotypes of the models that we tested, suggesting that PrP is not a major …
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Characterization of a novel mouse model and vaccines for pulmonary pathogens
… begins with a comprehensive review of the animal models and comparative pathology of three main etiologies of viral pneumonia, including SARS-CoV-2. There are several established transgenic mouse models for COVID-19, but due to differences in receptor distribution and expression levels, these …
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Synergistic inhibition of prostate tumor progression with a combination of curcumin and ursolic acid in the diet
… inhibited prostate tumor progression in two transgenic mouse models of PCa compared to single agents. Analyses of protein isolated from the ventral prostate of these mice indicated that the combination reduced activation of oncogenic signaling pathways, including STAT3, AKT, and mTORC1 …
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Molecular Control of Tooth Mesenchymal Stem Cell Activation
Background The continuously growing mouse incisor provides a robust model for studying molecular mechanisms of stem cell (SC) fate determination. While the epithelial SCs are well studied within this model, the identification and characterisation of a mesenchymal SC (MSC) population has yet to be …
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Therapeutic testing and epigenetic characterization of Friedreich Ataxia
… and CTMIO was investigated in GAA repeat FXN YAC transgenic mouse models of FRDA, but no significant improvements were detected on functional measurements such as rotarod performance and locomotor activity. Additionally such compounds failed to protect the brain of treated mice from oxidative …
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Compact tomographic X-ray phase-contrast imaging of breast cancer
… in visualizing pathological features by imaging transgenic mouse models of breast cancer. These pre-clinical results show that phase CT is able to clearly distinguish tumor masses whereas the same features imaged using commercial microCT are obscured by noise. Overall, the methods developed in …
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Novel Astrocyte-Specific Transgenic Mice Identify Distinct Populations of Transient Amplifying Progenitor Cells And Long-Lived Neural Stem Cells In the Subgranular Zone of the Adult Mouse Brain
… Using the CstC-CreERT2 and PLA2G7-CreERT2 mouse lines, in concert with the Rosa26YFP reporter line, cell fate tracking experiments were performed in both embryonic and adult time points in tandem with extensive immunohistochemistry. Both astrocyte-specific CreERT2 lines demonstrated limited …
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Cell-Type-Specific Requirement of Progestereone Receptor for Suppression of Cell Proliferation and Carcinogenesis in the Cervix
… promotes cervical carcinogenesis in HPV transgenic mouse models expressing HPV16–E6 and/or HPV16–E7. Our lab has demonstrated that synthetic progestin medroxyprogesterone acetate (MPA) prevents and regresses cervical cancer in the HPV transgenic mouse model. Our lab also has demonstrated …
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