Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 83 for “"Transgenic mouse model"”.
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A transgenic mouse model of hereditary motor and sensory neuropathy
… recombination in ES cells, we have generated a mouse containing a nonsense mutation in the intracellular portion of PO (Q215X) that, in the heterozygous state, is associated with CH neuropathy in humans. This mutation is predicted to encode a truncated PO protein, lacking part of the cytoplasmic …
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Anti-Cancer Effects Of Garcinol In Pancreatic Cancer Transgenic Mouse Model
… <em>invivo</em> effects of dietary Garcinol in a transgenic mouse model of Pancreatic Cancer (PaCa). This model is considered to be the animal model which best mimics development of human PaCa. Based on <em>invitro</em> data from our lab we hypothesized that Dietary Garcinol treatment will slow …
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Place cell physiology in a transgenic mouse model of Alzheimer's disease
… level, by examining place cell physiology in a transgenic mouse model of AD. I have recorded place cells in tg2576 mice, and found that aged (16 months) but not young (3 months) transgenic mice show degraded neuronal representations of the environment. The level of place cell degradation …
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SEX-DEPENDENT GUT MICROBIOME DIFFERENCES IN A TRANSGENIC MOUSE MODEL OF AUTISM
… amplicon sequencing on fecal samples taken from transgenic mice expressing human sAPPα(NtgsAPPα = 10; Nwt = 18). We found no evidence of a strong effect on alpha or beta diversity, but did find significant reductions in the proportional abundance of Akkermansia muciniphila within …
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From Gut to Brain - αSynuclein pathology spreading in a new transgenic mouse model
… been performed in patients as well as in animal models to investigate the spreading of αSyn from the periphery to the central nervous system (CNS). Animal models of αSyn gut-to-brain spreading are usually based on the injection of αSyn aggregates or on viral overexpression of αSyn, with both …
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Targeting Kremen1 Downregulation with RVG-9R/siRNA Complexes in the Triple-Transgenic Mouse Model of Alzheimer’s Disease
… and prevent synaptic loss in a cell culture model. This study focused on downregulating Krm1 the triple-transgenic mouse model of AD (3xTg-AD). It was hypothesized that application of siRNA-431 in vivo would downregulate Krm1 thereby preventing synaptic loss and memory deficits in the 3xTg-AD …
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The Apoptotic and Wallerian Degeneration Pathways Regulate Disease Onset and Progression in the SOD-1G93A Transgenic Mouse Model of ALS
… cell death and improves survival in an ALS mouse model. However, the timing and extent of axon degeneration in these mice is unaffected. Here, we examine the role of Sarm1, a component of the Wallerian degeneration pathway, and its interaction with the classical apoptotic cascade in ALS. …
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Impact of dietary tomato intake on prostate cancer throughout the course of disease development and progression in a transgenic mouse model
… the emergence or reduced the growth of CRPC in a mouse model of PCa (transgenic adenocarcinoma of the mouse prostate; TRAMP), castrated to mimic ADT. In this chapter, we aimed to investigate the molecular underpinnings of individual CRPC tumors with the hypothesis that dietary tomato or lycopene …
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The effects of Rhes, a striatal specific protein, on the expression of behavioral and neuropathological symptoms in a transgenic mouse model of Huntington's disease
… the symptoms of HD. We used a validated transgenic mouse model of HD crossed with Rhes knockout mice to show that the behavioral symptoms of HD are regulated by Rhes. HD/Rhes<sup>-/-</sup> mice showed greatly delayed expression of HD-like symptoms in this <em>in vivo</em> model. Drugs …
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The Effects of Treadmill Exercise in the P301S Mouse Model of Tau Pathology
… the impact of treadmill exercise in a transgenic mouse model of neurodegenerative tauopathy. The central hypothesis was that endurance treadmill exercise would slow the development of neurodegenerative tau pathology and associated behavioral impairments in the P301S-tau transgenic mouse …
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Humanized Mouse with a Diverse Polyclonal B Cell Repertoire as a Model for Neutralizing Antibody Responses against EBV and HIV
… However, it has been historically difficult to model human neutralizing B cell responses to these two viruses using small animals. I leveraged a transgenic mouse model that encodes a genetically human antibody repertoire to generate neutralizing monoclonal antibodies (mAbs) against the EBV gp350 …
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Microfluidic Technology for Low-Input Epigenomic Analysis
… DNA methylome during cancer development using a transgenic mouse model with microfluidic methylated DNA immunoprecipitation followed by next generation sequencing (MeDIP-seq) assays. Third, I explored negative enrichment of circulating tumor cells (CTCs) followed by microfluidic ChIP-seq …
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Apoptosis and Osteoblast Differentiation in the Periodontal Lignament in and in vivo Orthodontic Relapse Mouse Model
… of osteoblast differentiation in a mouse model of orthodontic relapse have yet to be demonstrated. It is the goal of this study to characterize and quantify osteoblast differentiation in orthodontic relapse in an <em>in vivo</em> transgenic mouse model. Transgenic mice with GFP bound …
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The Role of Trophic Factors and Other Drugs in the Treatment of Huntington's Disease in R6/2 Mouse Model
… We hypothesized that the treatment of the R6/2 transgenic mouse model with neurotrophic peptides, Colivelin and analogue dPEG-Colivelin, Sulforaphane, a compound that reduces oxidative stress, and Ceftriaxone, a GLT-1 upregulator, would attenuate motor behavioral abnormalities and …
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Development of novel diagnostics and therapeutics for amyotrophic lateral sclerosis
… during the disease progression of ALS in a transgenic mouse model, suggesting that Gd-TTC could be used as a biomarker for neurodegenerative diseases.TTC-conjugated nanoparticles were developed by synthesizing PLGA-PEG-biotin and using biotin binding proteins (avidin, streptavidin, and …
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Ligand-Directed Aavp to Deliver A Therapeutic Transgene to Neuroendocrine Tumors of The Pancreas
… homing and TNF expression <em>in vivo</em> in a transgenic mouse model of pancreatic neuroendocrine tumor development that mimics human disease. With further investigation, therapeutic gene delivery using the octreotide/SSTR2 ligand/receptor pair could represent a viable clinical alternative for …
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Twist of messenger Fate: novel mechanisms for TDP43 in modulating mRNA decay and alternative polyadenylation
… sequencing data of spinal cords from TDP43Q331K transgenic mouse model and of motor neuron-like NSC-34 cells silenced for TDP43 emerged that TDP43 plays another striking role in the 3’UTR, modulating mRNA alternative polyadenylation and promoting the generation of shorter transcripts. This …
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Studies on the production of IL-1β, TNF-α, iNOS, IL-10, and ROS in the APP/PS1 mouse model of Alzheimer's disease
… mediators and IL-10 in the cerebral cortex of transgenic mouse model of AD (APP/PS1). In transgenic mice, microglia and astrocytes were activated synchronously with Aβ deposits and were abundant and closely associated with senile plaques. At 14-17 months, microglia and astrocytes were …
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Role of the CTLA-4 receptor in regulatory T cell development, homeostasis and function
… T cell compartment. In addition, using a transgenic mouse model that permitted the development of antigen-specific Ctla-4-deficient Tregs, a role for the CTLA-4 receptor in Treg suppressive function was identified. The data obtained suggest that the CTLA-4 receptor may function on …
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