Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 208 for “"Transgenic mouse"”.
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Development of inducible transgenic mouse models for melanoma
… the purpose of this project was to establish a transgenic mouse model able to investigate the molecular mechanism(s) of melanoma aetiology mediated by N-Ras and PTEN genes. To achieve this, an inducible gene switch approach was employed exploiting the Cre/loxP recombinase system. This approach …
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Characterisation of transgenic mouse models of Alzheimer's disease
A number of transgenic mouse models have been developed to study the molecular and pathological alterations associated with Alzheimer’s disease (AD). The 3xTg mouse is widely used as a research tool and carries mutations in the amyloid precursor protein (Swedish APP K670N/M671L), presenilin 1 …
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A transgenic mouse model of hereditary motor and sensory neuropathy
… recombination in ES cells, we have generated a mouse containing a nonsense mutation in the intracellular portion of PO (Q215X) that, in the heterozygous state, is associated with CH neuropathy in humans. This mutation is predicted to encode a truncated PO protein, lacking part of the cytoplasmic …
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Anti-Cancer Effects Of Garcinol In Pancreatic Cancer Transgenic Mouse Model
… <em>invivo</em> effects of dietary Garcinol in a transgenic mouse model of Pancreatic Cancer (PaCa). This model is considered to be the animal model which best mimics development of human PaCa. Based on <em>invitro</em> data from our lab we hypothesized that Dietary Garcinol treatment will slow …
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Place cell physiology in a transgenic mouse model of Alzheimer's disease
… level, by examining place cell physiology in a transgenic mouse model of AD. I have recorded place cells in tg2576 mice, and found that aged (16 months) but not young (3 months) transgenic mice show degraded neuronal representations of the environment. The level of place cell degradation …
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SEX-DEPENDENT GUT MICROBIOME DIFFERENCES IN A TRANSGENIC MOUSE MODEL OF AUTISM
… amplicon sequencing on fecal samples taken from transgenic mice expressing human sAPPα(NtgsAPPα = 10; Nwt = 18). We found no evidence of a strong effect on alpha or beta diversity, but did find significant reductions in the proportional abundance of Akkermansia muciniphila within …
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Analysis of Circadian Rhythm Using a Novel SCN-Specific Cre Transgenic Mouse Line
… test this hypothesis, a novel SCN-specific Cre transgenic mouse line, named NMS-Cre, was developed by inserting a bicistronic Cre expression cassette at the 3’-untranslated region of the Neuromedin S (NMS) gene. By crossing NMS-Cre line to a lox-STOP-lox diphtheria toxin receptor line, …
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From Gut to Brain - αSynuclein pathology spreading in a new transgenic mouse model
… was to characterise a novel, non-invasive, transgenic mouse model of spontaneous αSyn gut-to-brain spreading.This mouse model, named Vitras, expresses aggregation prone human 1-120αSyn exclusively in the gut in a αSyn-null background. To determine whether the presence of human or mouse αSyn …
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Creation and establishment of transgenic mouse models for for Mecp2 gene, causing Rett syndrome
Das MeCP2 Protein ist ein transkriptonaler Repressor, der an methylierte Cytosine bindet und die Chromatinstruktur modifiziert. Mecp2 ist für 95% aller Rett-Syndrom-Fälle verantwortlich. Trotz der ubiquitären Expression von MeCP2 wird angenommen, dass es einzigartige Funktionen in Neuronen hat. …
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Phenotyping Double Transgenic Mouse Models of Alzheimer’s that Express Human APP and ApoE3 or ApoE4
… associated with a high risk for developing AD). Transgenic mouse models of AD are commonly used to study the neuropathological processes behind the development of Aβ plaques, neurodegeneration, and associated behavioral deficits. The current study was designed to determine whether expression of …
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Targeting Kremen1 Downregulation with RVG-9R/siRNA Complexes in the Triple-Transgenic Mouse Model of Alzheimer’s Disease
… study focused on downregulating Krm1 the triple-transgenic mouse model of AD (3xTg-AD). It was hypothesized that application of siRNA-431 in vivo would downregulate Krm1 thereby preventing synaptic loss and memory deficits in the 3xTg-AD mouse model of AD. Tail vein injections of RVG-9R/siRNA …
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The Apoptotic and Wallerian Degeneration Pathways Regulate Disease Onset and Progression in the SOD-1G93A Transgenic Mouse Model of ALS
… cell death and improves survival in an ALS mouse model. However, the timing and extent of axon degeneration in these mice is unaffected. Here, we examine the role of Sarm1, a component of the Wallerian degeneration pathway, and its interaction with the classical apoptotic cascade in ALS. …
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Impact of dietary tomato intake on prostate cancer throughout the course of disease development and progression in a transgenic mouse model
… the emergence or reduced the growth of CRPC in a mouse model of PCa (transgenic adenocarcinoma of the mouse prostate; TRAMP), castrated to mimic ADT. In this chapter, we aimed to investigate the molecular underpinnings of individual CRPC tumors with the hypothesis that dietary tomato or lycopene …
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The effects of Rhes, a striatal specific protein, on the expression of behavioral and neuropathological symptoms in a transgenic mouse model of Huntington's disease
… the symptoms of HD. We used a validated transgenic mouse model of HD crossed with Rhes knockout mice to show that the behavioral symptoms of HD are regulated by Rhes. HD/Rhes<sup>-/-</sup> mice showed greatly delayed expression of HD-like symptoms in this <em>in vivo</em> model. Drugs …
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Chemical and physical properties of bovine alpha-lactalbumin, beta-casein and genetically altered bovine beta-casein produced in the milk of transgenic mice
… region (2.0 kb) were expressed in two lines of transgenic mice, $\alpha$-114 and $\alpha\beta$ 34, respectively. Whey proteins, caseins, or skim milk proteins of the transgenic mouse milk containing bovine $\alpha$-lactalbumin or bovine $\beta$-casein were analyzed and separated by …
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The development of peptide-based inhibitors of the low affinity Fc receptor, Fc [gamma] RIIa
… events. There is now strong evidence from transgenic mouse models and human genetic susceptibility studies that implicate FcyRIIa in a number of immune diseases including, rheumatoid arthritis, systemic lupus erythematosus (SLE) and immune thrombocytopenia purpura (ITP). FcyRHa is therefore …
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Studies on the production of IL-1β, TNF-α, iNOS, IL-10, and ROS in the APP/PS1 mouse model of Alzheimer's disease
… mediators and IL-10 in the cerebral cortex of transgenic mouse model of AD (APP/PS1). In transgenic mice, microglia and astrocytes were activated synchronously with Aβ deposits and were abundant and closely associated with senile plaques. At 14-17 months, microglia and astrocytes were …
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