Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 320 for “"Transgenic mice"”.
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Lycopene metabolism in transgenic mice
… by BCO2, but metabolites have been detected in mice lacking BCO2. Additionally, in vitro studies in E. Coli have demonstrated that BCO1 preferentially cleaves lycopene. To confirm the primary cleaving enzyme on lycopene, we used four groups of mice; wild type (WT), Bco1 knock out (-/-), Bco2 …
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Bone Characterization of Dicer Deficient Transgenic Mice Under Dmp1 Promoter
… the femoral and calvarial bone phenotypes of transgenic mice that lack functional miRNAs in osteocytes. The calvarial bone of age and sex-matched Dicer-deficient mice under the Dmp1 promoter and their controls were characterized using microcomputed tomography, shape analysis and H&E …
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HUMAN DPP4/CD26 TRANSGENIC MICE AS SURROGATE MODELS FOR MERS
… and treatment of MERS-CoV infection and disease. Mice and other commonly used laboratory small animal species (i.e., hamsters and ferrets) are not susceptible to MERS-CoV because they lack the expression of human dipeptidyl peptidase 4 (hDPP4), the functional viral entry receptor. To overcome this …
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THE CHARACTERIZATION OF BEHAVIORAL ABNORMALITIES IN BDNF LOXP TRANSGENIC MICE
<p>BDNF homozygous floxed mice (BDNF<sup> lox+/+</sup>) are a transgenic mouse strain used to study the neurotrophin brain-derived neurotrophic factor (BDNF) through Cre-Lox recombination when crossed with the appropriate Cre-expressing strain. BDNF<sup> lox+/+</sup> mice contain two artificially …
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Cold-Induced Metabolic Changes in Lean, NAG-1 Transgenic Mice
… and becomes metabolically active. In this study, transgenic mice that constitutively express the human non-steroidal anti-inflammatory gene 1 (NAG-1) were used as a model to further understand the mechanisms of increasing metabolism. At room temperature, NAG-1 mice have less adipose tissue, higher …
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The generation and characterization of transgenic mice expressing modifiers of Rho GTPases
… in neurons (Binder et al., 1995). We used this transgenic strategy to analyze the effects of Rho family GTP-binding proteins on axonal outgrowth in early nervous system and the effect of long-term inhibition of Rho function in the adult brain. The recombinant protein of N19-RhoA was expressed in …
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The Effects of Induced Polycystic Ovary Syndrome in NAG-1 Transgenic Mice
… metabolic disorders and weight gain in mice. We hypothesized that the expression of NAG-1 may also prevent hormonal-induced metabolic disorders. To test this question, we induced PCOS via dihydrotestosterone (DHT) implantation in transgenic mice expressing the human NAG-1 gene. Our …
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Identifying Potential Agonists Of TRPA1 Using A Heterologous Expression System And Transgenic Mice
… assay was conducted using wild type and TRPA1-/- mice to determine if TRPA1 was activated by the stimuli. Overall, five novel TRPA1 agonists (alpha-terpineol, amyl acetate, benzaldehyde, d-limonene, toluene) were identified. It remains unclear whether acetic acid, cyclohexanone and denatonium …
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Staphylococcal Enterotoxin B Induced Clonal Anergy in αβ T Cell Receptor Transgenic Mice
… ovalbumin (OVA) specific αβ T cell receptor transgenic mice with SEB. Cells from these mice appeared to be anergic in that they were hyporesponsive to OVA peptide as well as to SEB. The anergic cells could respond to PMA and ionomycin suggesting that a proximal signal transduction step was …
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Mitotic homologous recombination at engineered repeats in S. cerevisiae and in novel transgenic mice
Although homologous recombination provides an efficient means for repairing and tolerating DNA damage, mitotic recombination between misaligned sequences can lead to loss of genetic information (e.g. deletions, translocations and loss of heterozygosity). Given that such genetic changes may promote …
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The Role of Connexin36 in Dopamine D1/D2 Synergism and its Breakdown in Transgenic Mice
… as manifested behaviorally, was studied here in mice genetically engineered to express normal, reduced, or undetectable amounts of this protein. The results show that D1/D2 synergism and its breakdown were not affected by the presence or absence of Cx36. Unexpectedly, it was observed that the …
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Effects of a Serine 364 to Proline Mutation of the Connexin43 Protein in Transgenic Mice
<p>[Abstract Not Included]</p>
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Functional analysis of insulin-like growth factor binding protein -4 and -6 in transgenic mice
… specific roles in vivo are largely unknown. Transgenic mice overexpressing a particular IGFBP allow us to investigate the specific functions of the corresponding IGFBP in vivo. To this end, IGFBP-4- and IGFBP-6-overexpressing models were established and analyzed in the present study. First, …
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Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation
… in urban regions compared to rural regions. Mice with an activating mutation in STAT6, known as STAT6VT, constitutively express STAT6 in T-cells. Our preliminary data suggests significant differences between the STAT6VT transgenic mice from WT littermate controls treated with SLS. These …
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Neuropathological characterization of transgenic mice with astrocyte-directed production of the CXC chemokine ligand 10
… of CXCL10 production in the CNS was examined in transgenic mice with astrocyte-directed production of this chemokine. <br>These glial fibrillary acidic protein (GFAP)-CXCL10 transgenic mice developed spontaneous, transgene dose- and age-related leukocyte infiltrates in perivascular, meningeal and …
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Use of transgenic mice to study the role of autophagy protein ATG16L1 in Crohn’s Disease
… this question we generated and characterised mice with an intestinal epithelial cell (IEC)-targeted deletion of Atg16L1 (Atg16L1ΔIEC) and validated our findings by histological analysis of intestinal tissue from CD patients expressing the CDrisk variant of ATG16L1 (*300A). To determine whether …
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Tissue lycopene absorption and accumulation in transgenic mice lacking one or both carotenoid cleaving enzymes
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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