Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Transgenic Animal Model"”.
-
Clinical and pathological characterization of a novel transgenic animal model of diabetes mellitus expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPR dn)
… and pathological characterization of a novel transgenic animal model of diabetes mellitus expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPR dn) Gastrointestinal hormones like glucose-dependent insulinotropic polypeptide have recently been shown to be …
-
Characterization of Inducible SMC-specific Drosha Knockout Mice
… maintain the differentiation state of SMCs. A transgenic animal model to study SMC-specific knockout of Dicer, one of two RNase III proteins in miRNA biogenesis, showed that contractile motility in the mutant intestine was dramatically decreased (Park, Yan, et al., 2011). The purpose of this …
-
Targeted Overexpression Of Metallothionein In Endothelial Cells Mitigates Pulmonary Alveolar Basement Membrane Thickening In Transgenic Diabetic Ove Mice: An Unbiased Tem Morphometric Analysis
… therapy, we crossed the severely diabetic transgenic mouse (OVE) with Jtmt, our recently developed transgenic animal model that overexpresses the antioxidant metallothionein (MT) in endothelial cells. Unbiased TEM morphometry demonstrated that PABM widths in diabetic (OVE) mice were …
-
STUDIO DEL RUOLO DELLA PROTEINA PRIONICA NELLA REGOLAZIONE DEL SONNO MEDIANTE L'UTILIZZO DI MODELLI MURINI TRANSGENICI
… in Knock-out mice. We generated a new mouse model of CJD (Tg(CJD)) that express the murine homologue of the D178N/V129 human mutation. We used as control mice Knock-out (KO) for the PrP, mice that over-express the normal form of the PrP Tg(WT) and Wt mice. Goals: 1) the characterization of …
-
New Therapeutic Strategies for Amyotrophic Lateral Sclerosis Treatment
… mutations in superoxide dismutase 1 (SOD1). The transgenic animal model of ALS was the G93A mouse that expresses a mutant form of human SOD1 carrying the Gly93 → Ala and develops motor neuron disease similar to familial ALS. With the lack of effective drug treatments for ALS and compelling …
-
Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE)
… of MOG-induced EAE in the DA rat, an animal model, which reproduces the immunopathology of the type II MS lesion (Lucchinetti et al., 2000). A newly established immunisation protocol results in a highly synchronised biphasic form of EAE, which mimics the disease course of secondary …