Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Transfusion Medicine"”.
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Transfusion medicine knowledge amongst specialist trainees at Groote schuur Hospital -using the BEST-TEST
Background: The primary aim was to assess transfusion medicine knowledge amongst specialist trainees at a South African tertiary hospital. Secondary aims included identifying shortcomings and describing differences in knowledge between subspecialty groups, comparing self-perceived knowledge against …
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Forward programming of human pluripotent stem cells to a megakaryocyte-erythrocyte bi-potent progenitor population: an in vitro system for the production of platelets and red blood cells for transfusion medicine.
… a need to produce platelets in vitro for use in transfusion medicine, due to increased platelet demands and short shelf life. Our lab uses human induced pluripotent stem cells (iPSCs), as an attractive alternative supply, as iPSCs can be cultured indefinitely and differentiate into almost any …
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The Johnson and Johnson journey deploying SmartOps for multi-echelon inventory optimization
… that focused on implementing SmartOps in the Transfusion Medicine and Mainframe Slides businesses within Ortho Clinical Diagnostics, a group within the Medical Devices and Diagnostics sector. Through a pilot program, this internship analyzed the level of complexity involved in deploying …
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Blood Donor Genotyping
Transfusion of blood is one of the oldest and most widely used clinical interventions. In 2020 the World Health Organisation reported that globally 118.5 million blood donations had been collected worldwide. This blood will be used to provide life-saving transfusion support for millions of …
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Genetic Characterisation of Human ABO Blood Group Variants with a Focus on Subgroups and Hybrid Alleles
ABO is the most important blood group system in transfusion medicine and transplantation immunology. The ABO blood groups differ by the presence or absence of antigens on RBCs and antibodies in plasma. Accurate determination of ABO status is critical. Genomic typing can increase the precision of …
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Demographic Characteristics and Academic Measures as Predictors of Success on the American Society for Clinical Pathology (ASCP) Medical Technologist Certification Examination
… in descending order were Immunohematology and Transfusion Medicine GPA, Clinical-year Didactic GPA, Clinical Year GPA, Clinical Chemistry GPA, Cumulative Graduating GPA , and Hematology and Hemostasis GPA. Most of the academic measures variables also showed significant relationships with the …
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On the function of the interferon-inducible p53 target gene TRIM22
The interferon-inducible p53-target gene TRIM22 (Staf50) is a member of the TRIM (TRIpartite Motif) family. The TRIM family is a family of RING (Really Interesting New Gene) proteins, defined through a tripartite motif, containing a RING-domain, one or two B-boxes and a Coiled-coil-domain. The TRIM …
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Eficacia de la Trasfusión de Plasma Convaleciente en Pacientes con Enfermedad Grave por Covid-19, Período Abril 2020-Abril 2021. Revisión Bibliográfica.
En la presente revisión se toman en cuenta aquellos artículos publicados en el periodo de abril 2020 a abril 2021, haciendo énfasis especialmente en sus potenciales ventajas como parte del manejo terapéutico de la enfermedad, así como en sus posibles riesgos a los pacientes manejados con dicho …
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A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion
The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in …
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Novel findings on cellular trafficking and targeting for granule storage of neutrophil elastase, a multifunctional effector molecule of innate immunity
Neutrophil elastase (NE) has important roles in innate immunity, killing pathogens and controlling the immune response; but how NE is targeted to developing granules is not understood. Therefore, the aim of this thesis was to investigate the sorting of NE. Transfection experiments in a leukemic …
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TRIM22/Staf50 - a novel target gene of the tumor suppressor p53
The tumor suppressor gene p53 is a transcription factor that mediates cell cycle arrest, apoptosis and differentiation. p53 mediated differentiation of leukemic cells depends on the transcriptional activity of p53 but so far no obvious differentiation inducing target gene has been identified. Using …
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The role of the leukemia-associated ETO homologue repressors in hematopoiesis
The fusion protein AML1-ETO is observed in acute myeloid patients with the chromosomal translocation t(8;21). Cells with this chimeric protein have impaired granulocytic and erythroid differentiation with accumulation of myeloblasts. The transcriptional co-repressor ETO (Eight Twenty One) was …
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Mechanisms for Targeting of Proteins to Secretory Lysosomes of Haematopoietic Cells
The cells of the innate immune system are essential for the host's first line defence against infection. Among these cells the neutrophil granulocyte has a central role by the production of antibiotic proteins and peptides. These are targeted for storage in secretory lysosomes and other neutrophil …
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Characterization of human myeloid progenitors and their differentiation
All hematopoietic cells are derived from the hematopoietic stem cells (HSCs) in a continuous and dynamic process, regulated by a network of transcription factors in different combinations and extrinsic signals from growth factors (GFs) and other factors in the microenvironment. In the initial …
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The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity
The Wilms tumor gene 1 (WT1) encodes a zinc-finger containing transcription factor which is highly expressed in immature hematopoietic progenitor cells. A high expression of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. The …
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Characterisation of the leukaemia-associated ETO homologues
Acute myeloid leukemia (AML) is commonly associated with balanced chromosomal translocations. Characteristically, these translocations lead to the fusion of two unrelated genes, resulting in the expression of an aberrant fusion protein. t(8;21) is one of the most common translocations found in …
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Studies of the ABO and FORS Histo-Blood Group Systems: Focus on Flow Cytometric and Genetic Analysis
… ABO gene or acquired changes in the setting of transfusion, pregnancy or stem cell transplantation. The O2 allele has been proposed sometimes to give rise to weak A expression. In 40 group O blood donors heterozygous for the O2 allele no A antigen expression could be detected nor could any GTA …
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Separation and Further Characterization of Hematopoietic Cell Populations Based on Phenotypic and Biophysical Properties
… differentiation and in the chimeric state of transfusion and allogeneic HSCT. Furthermore, novel technology platforms for optimal HSCT graft engineering in the setting of recipient-donor tissue antigen disparity were investigated. We utilized two in vitro culture systems (Paper II) to obtain …