Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Transforming growth factor-β (TGF-β)"”.
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The study of tumor-derived Smad4 mutations in transforming growth factor β (TGF-β) signaling
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The Role of Perivascular Fibrosis In Post-Stroke Glymphatic Impairment and Cerebral Amyloid Angiopathy
… hypothesize that inhibition of astrocytic transforming growth factor-β (TGF-β) signaling can reverse these phenotypes. Finally, I also hypothesize that serum biomarkers of perivascular fibrosis can be used to diagnose CAA following intracerebral hemorrhage (ICH). To test these hypotheses, I …
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Biomolecules that impact phenotypic transitions in fibroblasts and macrophages
… eventual resolution of this response. Following, transforming growth factor-β (TGF-β) activation, fibroblasts differentiate into myofibroblasts; these cells will secrete and contract extracellular matrix (ECM) components into a fibrous capsule. Herein, a library of modified poly-L-arginine (PLR) …
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Effect of Anti-fibrotic Drug (Pirfenidone) on TGF-β Signaling Pathway in Ocular Fibrotic Disorders
Purpose: Transforming growth factor-β (TGF-β) plays a key role in transforming retinal pigment epithelial (RPE) cells into mesenchymal fibroblastic cells, which are implicated in fibrotic disorders of the retina. Herein, the effect of pirfenidone, a novel anti-fibrotic agent, on TGF-β1-mediated …
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The Role of Type III Transforming Growth Factor-β Receptor in Regulating ALK1 Signaling and Endothelial Biology
<p>The Transforming Growth Factor-β (TGF-β) superfamily of ligands and receptors play critical roles in angiogenesis, evidenced by their essential role in physiologic angiogenesis and their perturbation in pathologic angiogenesis. In development, loss or mutation of Activin receptor-Like Kinase 1 …
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Effects of TGF-β Inhibitor on Chemoresistance in Ovarian Cancer Models
… in platinum resistant HGSC. High levels of Transforming Growth Factor-β (TGF-β) was linked to poor prognosis, chemoresistance and metastasis risk in HGSC. Mechanisms include roles of TGF-β promoting epithelial to mesenchymal transition (EMT) and immune evasion via suppression of Granzyme B …
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Suppressive Effects of Transforming Factor-β and Interleukin-10 on the Cytolytic Activity of Murine Macrophages and Reversal by Cytokines
<p>In this study, the suppressive effects of transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) on peritoneal macrophage killing of H238 target cells and the potential for reversal of the immunosuppressive effect by IL-4 and interferon-γ (IFN-γ) were investigated. The responsiveness of …
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Role of autocrine growth factors in the tumorigenic transformation of T cells
… may result from aberrant regulation of autocrine growth factor production. We describe for the first time characterization of several normal T cell lines that underwent spontaneous transformation resulting from constitutive expression of interleukin-2 (IL-2) and interleukin 2 receptor (IL-2R) …
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KLF4 IS A KEY DETERMINANT IN THE DEVELOPMENT AND PROGRESSION OF CEREBRAL CAVERNOUS MALFORMATIONS
… in a marked upregulation of the transcription factor Krüppel-like factor 4 (KLF4) in ECs in vivo. KLF4 promotes an endogenous production of bone morphogenetic protein 6 (BMP6) in ECs that, in turn, activates the transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) …
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Exploration of novel activin A antibodies
The transforming growth factor β (TGF-β) superfamily comprises the most structurally diverse family of growth factors and plays critical roles in embryogenesis and tissue homeostasis. A key feature of TGF-β growth factors is the regulatory pro-domain, which modulates the signalling activity of the …
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Internally Translated Cx43 Isoform GJA1-20k Affects Epithelial to Mesenchymal Transition and Metastatic Cancer Cell Behavior
… polarity, and cytoskeleton reorganization. Transforming Growth Factor-β (TGF-β) is well-established in driving cancer progression through EMT induction. Remodeling of cellular junctions, including gap junctions, is critical to acquiring migratory and invasive characteristics during EMT. The …
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TARGETING FIBROBLAST-MATRIX INTERACTIONS TO TREAT VOCAL FOLD SCARRING
… bed and secrete various cytokines, including transforming growth factor-β (TGF-β), to promote tissue repair. In response to these biochemical cues, VF fibroblasts undergo a fibroblast-to-myofibroblast transition. While myofibroblasts are required for wound closure and VF repair, persistent …
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Regulation of Hematopoietic Stem Cells
… studies presented in this thesis have identified factors involved in the regulation of HSC fate decisions. In summary, our results demonstrate that increased Smad4 expression, a key component in the transforming growth factor-β (TGF-β) signaling pathway, sensitizes human CB HSPCs to TGF-β. This …
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Immunological Crosstalk between Human Transforming Growth Factor-β1 and the Malaria Vector Anopheles stephensi
… of NOS gene expression and catalytic activity is transforming growth factor-β (TGF-β). Moreover, human TGF-β can activate Drosophila melanogaster Smads, the proteins responsible for TGF-β signal transduction. We have determined that following a bloodmeal, active human TGF-β1 (hTGF-β1) persists in …
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Tumor-induced macrophage and T cell dysfunction
… effector, and cytotoxic activities. Tumor growth changes the phenotypic and functional characteristics of MΦ and T cells and shifts them toward suppressor phenotypes and functional activities. Tumor growth changed MΦ DNA synthesis when activated through Mac-1 and Mac-3 surface molecules, …
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Transforming Growth Factor-Beta Signalling in Human Cutaneous Squamous Cell Carcinoma
… associated with poor survival. <br/><br/>The transforming growth factor-β (TGF-β) signalling pathway is known to play key regulatory roles in skin homeostasis and wound repair. Murine studies indicate that loss of TGF-β signalling is sufficient to drive cSCC, but conclusive evidence for a …
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A Study of TGF‐β Signaling in B Lymphocytes and Glioblastoma
<p>Transforming growth factor–β (TGF–β) signaling regulates a range of processes in a variety of cell types. Consequently, TGF–β plays a complex role in the progression of several types of cancers; it acts as a tumor suppressor in normal cells and early in tumor progression, yet it can promote …
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Targeting Organic Anion Transporting Polypeptide 1A4 (Oatp1a4) for Effective Drug Delivery at the Blood-Brain Barrier
… kinase 1 (ALK1), a critical component of the transforming growth factor-β (TGF-β) pathway, using the selective agonist Bone Morphogenetic Protein (BMP)-9 increases Oatp1a4 protein expression in rat brain microvessels in vivo. Additionally, we demonstrate that BMP-9 treatment increases …
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Characterisation of BMP Processing and Signalling in Adipocytes
… Bone morphogenic protein (BMP) 8B, part of the Transforming Growth Factor-β (TGF-β) superfamily, is key in regulating energy balance via activating brown adipose tissue (BAT) thermogenesis, presenting a potential target for obesity treatment. However, the molecular mechanisms underlying BMP8B …
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Untersuchungen zur Regulation der humanen Xylosyltransferase-I bei Fibrosen
… This study revealed activin A, a cytokine of the transforming growth factor β (TGF-β) family, as a potent regulator of XYLT1 mRNA expression and XT activity in normal human dermal fibroblasts (NHDF). Using small molecule inhibitors and small interfering RNAs, the activin A-mediated XT-I increase …
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