Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Transforming growth factor Beta (TGF-β)"”.
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Modulating Bone morphogenetic protein (BMP) and Transforming growth factor-beta (TGF-β) signalling with green tea catechins in mammalian cells
… mutation in the BMPR2 gene, a member of the TGFβ Superfamily. In this study, it was hypothesised that these green tea catechin compounds might inhibit TGFβ signalling while promoting BMP signalling. This study demonstrates that these green tea catechin compounds inhibit TGFβR-II and …
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Post-Translational Regulation of Zeb1 Contributes to Tgfβ-Mediated Emt
… is mediated by several signaling pathways, with transforming growth factor-beta (TGF-β) receiving attention for its up-regulation in the metastatic tumor microenvironment. TGF-β facilitates EMT through a variety of mechanisms but a prominent feature of TGF-β induced EMT is the activation of the …
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The Role of TGF-β in CTB-Insulin Regulated Human Dendritic Cell Tolerance
… of DC activation. Previous studies suggest transforming growth factor beta (TGF-β) may play a role in the stimulation of IDO1 biosynthesis for induction of immunological tolerance in murine DCs. To elucidate the mechanisms by which CTB-INS may stimulate IDO1 biosynthesis and mediate …
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Developing a co-culture model of ovarian cancer to identify immunotherapies that can overcome TGF-β-induced immunosuppression
… in the tumor microenvironment (TME), notably transforming growth factor beta (TGF-β). TGF-β suppresses anti-tumor immunity, including the expression of granzyme B (GzmB) and other cytolytic effectors in CD8+ T cells. To address this challenge, we established a simplified co-culture model of …
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Análise de Variantes Genéticas no gene da Endoglina em Leucemias Linfoblásticas Agudas de Células B Pediátricas
… (ENG, CD105) is a co-receptor part of the transforming growth factor beta (TGF-β) family, described as a powerful marker of the angiogenesis process. Recently, endoglin (ENG) has been increasingly studied in the context of hematopoietic neoplasms. ENG expression is reported in blasts in …
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Behavioural and Metabolic Characterization of NPR-9 and AIB Signaling Dynamics in Caenorhabditis Elegans
… while favouring conditions that promote growth. Therefore, organisms must detect environmental cues via sensory neurons, integrate sensory evoked signals via interneurons, and modulate downstream pathways dependent on environmental context. Internal cues, such as a well fed or starved …
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Novel markers for human T regulatory cells in healthy donors and cancer patients
… Human Tregs secrete the latent form of transforming growth factor-beta (TGF-β), in which the mature TGF-β protein is bound to latency-associated peptide (LAP) that binds to Glycoprotein A Repetitions Predominant (GARP). Some FoxP3+ Tregs express Helios, a member of the Ikaros …
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Breaking the MF curse: the regulatory role of the Methyl farnesoate – MEKRE93 pathway in crustacean molting
… of the exoskeleton, is critical for arthropod growth, development, and/or regeneration of lost or damaged appendages. The antagonistic interaction between the steroid hormone 20-hydroxyecdysone (20-E) and the sesquiterpenoid juvenile hormone (JH) control insect molting and development, …
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Investigation of the proteins SPARC and HMGB1 in chronic airways disease
… SPARC also serves as a down-stream mediator of transforming growth factor-beta (TGF-β), a key driver of airway remodeling in chronic airways disease, and demonstrates context-dependent immunoregulatory functions. Although airway inflammation and remodeling are prominent features of asthma and …
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Rational Identification of Neuropilin-1 Inhibitors: From Deep-Learning to Drug Repurposing
… potentiates signalling from vascular endothelial growth factor (VEGF), Semaphorins, transforming growth factor beta (TGF-β) and other axes central to angiogenesis, tumour progression, viral entry and immune regulation. Despite this compelling biology, no potent NRP1 inhibitors have been approved, …
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Annexin A1 im chronischen Nierenversagen
… dazu war die mRNA Expression von Annexin A1 und Transforming growth factor beta (TGF-β) signifikant erhöht. Die Annexin A1-Lokalisation mittels Doppelimmunfluorsezenz identifizierte eine große Anzahl von CD73-positiven kortikalen Fibroblasten und eine Subpopulation von Makrophagen als Annexin …
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Human immunodeficiency virus (HIV)-mediated cardiac fibrosis: implication of cellular immunomodulation and cytokine profile alterations
… CD4 count), plasma biomarkers (tumor necrosis factor-alpha (TNF-α), interleukin 1-beta (IL-1β), IL-4, IL-6, IL-10, IL-13, transforming growth factor-beta (TGF-β), osteopontin and hematological tests. The major findings from the main study demonstrated a coordinated pro-fibrotic immune profile …
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Smad Proteins and theTgf-Beta Signaling Pathway During In Vitro Progression of Hpv16-Immortalized Human Keratinocytes' and 'Microarray Gene Expression Profiling of Exfoliated Cervical Cells'
<p>Disruption of the transforming growth factor-beta (TGF-β) signaling pathway is observed in many cancers, including cervical cancer, resulting in TGF-β resistance. While normal human keratinocytes (HKc) and human papillomavirus type 16 immortalized HKc (HKc/HPV16) are sensitive to the growth …