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Showing 1 to 20 of 37 for “"Transforming Growth Factor-beta (TGF-¿)"”.

  1. Phosphorylation and activation of transforming growth factor beta (TGF-[beta]) receptor kinases

    Chen, FengMassachusetts Institute of Technology1996

    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.

    mit Repository record

  2. Chronic kidney disease in HIV populations: prevalence, risk factors and role of transforming growth factor beta (TGF-߀1) polymorphisms

    Ekrikpo, Udeme EkpenyongDepartment of Medicine2019

    … to investigate the diagnostic utility of urinary transforming growth factor-beta-1 (TGF-β1) for CKD in the HIV population and determine the association between polymorphisms of TGF-β1 gene and prevalent CKD. Methods: A meta-analysis was performed to document the prevalence of CKD in the global HIV …

    cape-town Repository record

  3. Modulating Bone morphogenetic protein (BMP) and Transforming growth factor-beta (TGF-β) signalling with green tea catechins in mammalian cells

    Nganwuchu, Chinyere C.University of Bradford2025

    … mutation in the BMPR2 gene, a member of the TGFβ Superfamily. In this study, it was hypothesised that these green tea catechin compounds might inhibit TGFβ signalling while promoting BMP signalling. This study demonstrates that these green tea catechin compounds inhibit TGFβR-II and …

    bradford Repository record

  4. Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins. Effect of transforming growth factor-beta (TGF-¿1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins.

    Khaghani, Seyed AliUniversity of Bradford2012

    … change characterized as dedifferentiation. Transforming growth factor-beta (TGF-¿), a cytokine superfamily, regulates cell function, including differentiation and proliferation. The effect of TGF-¿1, 2, 3, and their manipulated forms in biological regulation of primary chondrocyte was …

    bradford Repository record

  5. Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins. Effect of transforming growth factor-beta (TGF-¿1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins.

    Khaghani, Seyed A.University of Bradford2012

    … change characterized as dedifferentiation. Transforming growth factor-beta (TGF-¿), a cytokine superfamily, regulates cell function, including differentiation and proliferation. The effect of TGF-¿1, 2, 3, and their manipulated forms in biological regulation of primary chondrocyte was …

    bradford Repository record

  6. Effects of Docosahexaenoic Acid on TGF-ß and SMAD Proteins in COLO205 and WiDr Cells

    Ma, VincentUniversity of Nevada, Reno2011

    Transforming growth factor beta (TGF-ß), a cytokine capable of altering cell growth and differentiation, as well as related transcription factors called SMADs, are among the proteins known to be modified by docosahexaenoic acid (DHA) treatment in T-cells. Unpublished data has indicated that these …

    unr Repository record

  7. Ueber die Funktion von Zinkfinger Proteinen bei der Induktion des Mesoderms in Xenopus laevis

    Duerr, Ulrike2012

    … Invertebraten wird u.a. von Zy tokinen der '' transforming growth factor-beta'' (TGF-beta) Familie reguliert. In der Zielzelle ver mitteln Smad Proteine die Signalweitergabe von der Zellmembran in den Zellkern. Hier kooperieren di e Smad-Proteine mit gewebsspezifischen Transkriptionsfaktoren, …

    goettingen Repository record

  8. Regulation of specific connexins differentially alters gap junction permeability and endothelial cell function

    Elihu, David MoradMassachusetts Institute of Technology2006

    … mediating the expression of vascular regulators transforming growth factor-[Beta][ (TGF-[beta]), prostacyclin, and endothelial nitric oxide synthase (eNOS). siRNA inhibition of connexin 43 in porcine aortic endothelial cells (PAEC) significantly decreased the diffusion distance of Lucifer yellow …

    mit Repository record

  9. Bone morphogenetic proteins (BMPs): new modulators of the follicle stimulating hormone (FSH) synthesis and release

    Faure, Marie-OdileThe University of Edinburgh2006

    … females, to coordinate the terminal follicular growth, the follicle selection as well as the timing and the number of ovulation. Synthesis and release of both gonadotropins are controlled by hypothalamic gonadotropin releasing hormone (GnRH) and gonadal steroids (progesterone and oestradiol). …

    edinburgh Repository record

  10. Post-Translational Regulation of Zeb1 Contributes to Tgfβ-Mediated Emt

    Manshouri, Roxsan2015

    … is mediated by several signaling pathways, with transforming growth factor-beta (TGF-β) receiving attention for its up-regulation in the metastatic tumor microenvironment. TGF-β facilitates EMT through a variety of mechanisms but a prominent feature of TGF-β induced EMT is the activation of the …

    uthsc Repository record

  11. TGF-beta signaling at the cellular junctions

    Dudu, VeronicaTechnische Universität Dresden

    … melanogaster as a model organism, I have studied transforming growth factor-beta (TGF-beta) signal from the secreting to the receiving cells in the developing wing epithelial cells and at the neuromuscular junctions. Cell culture studies have suggested that cells modulate morphogenetic signaling …

    qucosa-diss

  12. Engineering B Cells For Use In Immunotherapy and Cancer

    Ensley, Emily, <p>https://orcid.org/0000-0003-4212-2260</p>2022

    … including interleukin (IL)-10, IL-35 and transforming growth factor-beta (TGF-b). Ex vivo expansion of B cells has been challenging due to their tendency to undergo apoptosis in culture. Thus, creating a successful expansion protocol with exceptional viability will open the door for B …

    uthsc Repository record

  13. The Role of TGF-β in CTB-Insulin Regulated Human Dendritic Cell Tolerance

    Esebanmen, Grace Edosewe

    … of DC activation. Previous studies suggest transforming growth factor beta (TGF-β) may play a role in the stimulation of IDO1 biosynthesis for induction of immunological tolerance in murine DCs. To elucidate the mechanisms by which CTB-INS may stimulate IDO1 biosynthesis and mediate …

    loma-linda Repository record

  14. Developing a co-culture model of ovarian cancer to identify immunotherapies that can overcome TGF-β-induced immunosuppression

    Potts, Amelia2024

    … in the tumor microenvironment (TME), notably transforming growth factor beta (TGF-β). TGF-β suppresses anti-tumor immunity, including the expression of granzyme B (GzmB) and other cytolytic effectors in CD8+ T cells. To address this challenge, we established a simplified co-culture model of …

    queens Repository record

  15. The structure of human pro-myostatin and molecular basis of latency

    Cotton, Thomas RichardUniversity of Cambridge2019

    Myostatin is a secreted growth factor of the transforming growth-factor $\beta$ (TGF$\beta$) superfamily, and a powerful negative regulator of muscle mass in vertebrates. As such, there is considerable interest in developing pharmacological agents which inhibit myostatin signalling in order to …

    cambridge Repository record

  16. Análise de Variantes Genéticas no gene da Endoglina em Leucemias Linfoblásticas Agudas de Células B Pediátricas

    Siqueira, Yasmim Cristina Ferreira de AlmeidaUniversidade Federal da Bahia2024

    … (ENG, CD105) is a co-receptor part of the transforming growth factor beta (TGF-β) family, described as a powerful marker of the angiogenesis process. Recently, endoglin (ENG) has been increasingly studied in the context of hematopoietic neoplasms. ENG expression is reported in blasts in …

    brazil-ufba Repository record

  17. Behavioural and Metabolic Characterization of NPR-9 and AIB Signaling Dynamics in Caenorhabditis Elegans

    Campbell, Jason2018

    … while favouring conditions that promote growth. Therefore, organisms must detect environmental cues via sensory neurons, integrate sensory evoked signals via interneurons, and modulate downstream pathways dependent on environmental context. Internal cues, such as a well fed or starved …

    queens Repository record

  18. Novel markers for human T regulatory cells in healthy donors and cancer patients

    Abd Al Samid, M2026

    … Human Tregs secrete the latent form of transforming growth factor-beta (TGF-β), in which the mature TGF-β protein is bound to latency-associated peptide (LAP) that binds to Glycoprotein A Repetitions Predominant (GARP). Some FoxP3+ Tregs express Helios, a member of the Ikaros …

    salford Repository record

  19. The Role of Extracellular Matrix Rigidity and Altered microRNA Expression In TGF-beta-Mediated Breast Cancer Progression

    Taylor, Molly AnnCase Western Reserve University School of Graduate Studies2013

    … underlying this event remain poorly defined. Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that functions to suppress tumorigenesis in mammary epithelial cells (MECs). Interestingly, mammary tumorigenesis converts TGF-beta from a tumor suppressor to a tumor promoter …

    ohiolink Repository record

  20. In vivo Genome-wide Expression Study on Human Blood B cells Suggests a Novel ESRI and MAPK3 Network for Postmenopausal Osteoporosis

    Xiao, PengCreighton University2007

    … via expression of osteoclast-related factors, such as receptor activator of NF-kappaB ligand (RANKL), transforming growth factor beta (TGF-~), and osteoprotegerin (OPG). In addition, Bcell precursors are able to differentiate into osteoclasts in vitro. However, the role of B cells in …

    creighton Repository record

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