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Showing 1 to 20 of 27 for “"Transforming Growth Factor beta 1"”.

  1. Transforming growth factor beta 1 : Role in the progression of chronic renal failure.

    Khalil, Mahmoud Salah.Sheffield Hallam University (United Kingdom).2002

    TGF-beta1 plays an important role in the pathogenesis of experimental and clinical glomerulosclerosis and tubufointerstitial fibrosis. Associations have been described between polymorphisms of cytokine and growth factor genes and susceptibility to, or progression of, an increasing number of …

    sheffield-hallam Repository record

  2. Einfluß des Wachstumsfaktors transforming growth factor beta 1 auf die Proteoglycanbiosynthese in kultivierten humanen Chondrozyten

    Arens, SusanneMainz1995

    aachen Repository record

  3. Investigating the Role of Indoleamine 2,3-Dioxygenase 1 and Transforming Growth Factor Beta 1 in Rebound Immune Suppression Following Chemotherapy in Osteosarcoma

    Passos Barbosa, Matheus MorenoUniversity of Illinois at Urbana-Champaign2023

    Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms

    uiuc Repository record

  4. Zeitliche Expressionsprofile der Zytokine Interleukin-1 beta, Interleukin-6 und Transforming Growth Factor-beta 1 mittels real-time Polymerase Kettenreaktion (rt-PCR) im Myelonkompressionsmodell der Ratte

    Ringelstein, Marius JohannesMainz2007

    aachen Repository record

  5. Einfluss von vascular endothelial growth factor, transforming growth factor-beta-1, Interleukin-6, atrial natriuretic beptide, brain natriuretic peptide und Cortisol auf die Gen-Expression des menschlichen Herzmuskels in vitro

    Fliedner, Anselm

    … untersucht die Effekte von Vascular Endothelial Growth Factor (VEGF), Transforming Growth Factor-beta-1(TGF-beta-1), Interleukin-6 (IL-6), Atrial Natriuretic Peptide (ANP), Brain Natriuretic Peptide (BNP) und Cortisol (bzw. Dexamethason) auf das humane Myokard. Um Rückschlüsse auf mögliche …

    freiburg-diss Repository record

  6. Maintenance of fetal membrane integrity by cyclic cellular transitions during gestation and parturition

    Richardson, Lauren SThe University of Texas Medical Branch at Galveston2022

    … (OS) at term induces EMT, mediated in part by transforming growth factor beta 1 (TGF-β), TGF-β activated kinase binding protein (TAB1), and p38 mitogen-activated protein kinase (p38 MAPK) signaling in human and mice membranes. This process is balanced during gestation by progesterone (P4) which …

    utmb Repository record

  7. Proteomic comparison of biomaterial implants for regeneration of peripheral nerve tissue

    Miu, Kathy KMassachusetts Institute of Technology2009

    … time point for concentration differences in transforming growth factor beta 1, 2, 3 (TGF [beta]1, [beta]2, and [beta]3) and alpha smooth muscle actin ([aipha] SMA) to measure disparities in proteins associated with wound healing that may determine nonregenerative from regenerative outcomes. …

    mit Repository record

  8. The generation and maintenance of T Helper 17 cells in response to bacterial infection

    Linehan, Jonathan L.2012

    … studies have identified Interleukin-6 (IL-6) and Transforming Growth Factor-beta;1 (TGF-β1) as sufficient to induce T helper type-17 (TH17) differentiation in vitro, but it is unclear whether these factors are necessary, and if so, what the cellular source of these factors is in the context …

    umn Repository record

  9. Modulation of TGFβ1-induced Fibroblast-to-Myofibroblast Transition in response to Prostaglandin E2 Production by Human Rhinovirus-Infected Airway Epithelial Cells

    Pham, Diana MinhCumming School of Medicine2020

    … leading to the thickening of the airway walls. Transforming growth factor beta-1 (TGFβ1) is highly expressed in asthmatics and is known to upregulate fibroblast alpha-smooth muscle actin (α-SMA) expression, a characteristic marker of myofibroblasts. Given that human rhinovirus (HRV) infections …

    calgary Repository record

  10. The Glial Response to Focused Ultrasound-mediated Permeabilization of the Blood-brain Barrier: Evaluating the Potential Contribution of Microglia and Astrocytes to Pathology and Regeneration

    Silburt, Joseph Leib2021

    … microglia were deramified and upregulated transforming growth factor beta 1 (Tgfβ1), and activated astrocytes were hypertrophic and expressed nestin. MORPHIOUS can therefore sensitively detect activated glia. Secondly, I used MORPHIOUS to characterize microglial and astrocytic activation …

    toronto-retro Repository record

  11. Investigating the role of PKC-β in tumour activated stromal cells

    Timmins, MatthewUniversity of Cambridge2024

    … malignant B-cells. PKC-β dependent cell contact factors have been shown to regulate drug resistance, but the role of soluble-factors for this protection remains unknown. Moreover, the role of PKC-β in stromal cells of other cancers remains largely uncharacterised. Here I demonstrate novel …

    cambridge Repository record

  12. Role of Dopamine Receptor 3 in Cardiac Fibrosis

    Byrne, Shannon ElizabethEast Carolina University2021

    … fibroblasts. Finally, known profibrotic marker, transforming growth factor [beta]1 (TGF-[beta]1), and the angiotensin II receptor type I were examined. In the D3KO LV cardiac fibroblasts, angiotensin II receptor type I was significantly increased many folds. TGF-[beta]1 was also increased in D3KO …

    ecu Repository record

  13. Chronic kidney disease in HIV populations: prevalence, risk factors and role of transforming growth factor beta (TGF-߀1) polymorphisms

    Ekrikpo, Udeme EkpenyongDepartment of Medicine2019

    … to investigate the diagnostic utility of urinary transforming growth factor-beta-1 (TGF-β1) for CKD in the HIV population and determine the association between polymorphisms of TGF-β1 gene and prevalent CKD. Methods: A meta-analysis was performed to document the prevalence of CKD in the global HIV …

    cape-town Repository record

  14. Stress Conditioning and Heat Shock Protein Manipulation for Bone Tissue Engineering

    Chung, EunnaVirginia Tech2010

    … modulation and HSP induction may be critical factors for enhancing bone regeneration. We investigated whether applying individual or combinatorial stress conditioning (thermal, tensile, and biochemical) and effective HSP modulation could induce in vitro responses in preosteoblasts indicating …

    vt Repository record

  15. TGF-β Signaltransduktion in der experimentell induzierten Leberfibrose durch die Gallengangsligatur bei der Ratte

    Seyhan, HarunPublikationsserver der RWTH Aachen University2006

    Background/Aims: Profibrogenic TGF-beta signaling in hepatic stellate cells is modulated during transdifferentiation. Strategies to abrogate TGF-beta effects provide promising antifibrotic results, however, in vivo data regarding Smad activation during fibrogenesis are scarce. Methods: Here, liver …

    aachen Repository record

  16. Neuroprotective Potential of a Lanosteryl Triterpene from Protorhus longifolia Stem Bark (Benrh.) Engl in high fat diet fed and STZ -induced diabetic neuropathy in rats

    Ndlovu, MusawenkosiUniversity of Zululand2019

    … cellular and tissue damaging factors such as advanced glycation end product (AGE) formation, oxidative stress and inflammation. Activation of these pathophysiological pathways alters the antioxidant defense of nerve cells and cause protein malfunction, resulting in loss of …

    zulu Repository record

  17. Therapeutic Effect of a triterpenic Acid from Protorhus longifolia Against High Fat Diet Fed and Streptozotocin-induced Diabetic Nephropathy in Rats

    Mngomezulu, Thembekile S.K.University of Zululand2019

    … decreased renal levels of inflammatory markers (transforming growth factor beta-1, cycloogenase-2, TNF-α, and IL-6) in the diabetic group treated with RA5 when compared to the untreated diabetic control. The obtained results suggest that the diabetic RA5 possess therapeutic potential against DN.

    zulu Repository record

  18. Knochenneubildung durch induktive Implantate der TGF-Beta-Familie : eine tierexperimentelle Studie zum Synergismus von BMP-2-Mutanten und TGF-Beta bei der heterotopen Osteoinduktion

    Janke, Carsten Theodor WilhelmUniversität Würzburg

    … (BMP-2) und der regulative Einfluss des Faktors „Transforming growth factor beta 1“ auf das physiologische Remodelling des Knochens sind durch zahlreiche In-vitro- und In-vivo-Untersuchungen belegt. Die gentechnische Modifikation der N-terminalen Aminosäuresequenz von rekombinantem, im …

    wurz-thes Repository record

  19. Role of extracellular environment in mechanical properties of human cardiac fibroblasts and myofibroblasts

    Haasbroek, Pieter DaniëlDepartment of Human Biology2021

    … the latter obtained through stimulation with transforming growth factor-beta 1 (TGF-β1) of CF, were cultured and embedded in 3D PEG hydrogel matrices. PEG was supplemented with RGD peptides to provide cellular adhesion points, imitating the native myocardial environment. The intracellular …

    cape-town Repository record

  20. Investigating the effects of enhanced catecholamine stimulation in stem cell-derived cardiomyocytes

    Samodien, KautharDepartment of Human Biology2025

    … signalling of molecules such as stress-response growth factors. One such growth factor is the transforming growth factor beta 1 (TGF-β1) which plays a pivotal role in cardiac development but is also upregulated during heart failure. However, the contribution of TGF-β1 to cardiac remodelling has …

    cape-town Repository record

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