Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Transferrin receptor"”.
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Cleavage of exosomal-associated transferrin receptor in dogs, cats, and horses: progress towards a soluble transferrin receptor assay
… disease or the other. In human medicine, soluble transferrin receptor 1 (sTfR) has shown promise as a marker, alone or in ratio with serum ferritin, that can differentiate iron deficiency anemia, anemia of chronic disease, and combined disease. sTfR is the product of cleavage of transferrin …
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Deciphering the mechanism of Transferrin Receptor mRNA degradation under iron replete conditions
… controlled. For most cells in the body, the transferrin receptor (TFRC-1) is the major means through which iron is imported into the cell. Influx of transferrin bound iron is regulated by changes in the stability of TFRC-1 mRNA. Under iron deplete conditions, iron regulatory proteins 1 and 2 …
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Structure of the trypanosome transferrin receptor and insights into ligand binding and therapeutic strategies
… host response. In addition, a unique set of receptors mediate uptake of host macromolecules and must comply with recognising ligands from a broad host range whilst also avoiding immune detection. Host transferrin (Tf) is acquired by trypanosomes through the expression of a transferrin …
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Study of a Transferrin Receptor Brain Shuttle for the Delivery of Nanobodies Against GABAA Receptors
… emerged to improve drug delivery by targeting receptors present at the BBB, such as transferrin receptor (TfR), hijacking endogenous trafficking systems to shuttle conjugated therapeutic cargo from the blood circulation into the brain parenchyma. Such systems could be utilised to improve the …
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Studies on the role of hephaestin and transferrin in iron transport
… into blood. These ferroxidases supply transferrin, the iron-carrier protein in plasma, with Fe(III). Transferrin circulates through blood and delivers iron to cells via the transferrin receptor pathway. Due to the insoluble and reactive nature of free Fe(III), the oxidation of Fe(II) …
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Identification and Characterization of Effectors/Binding Molecules for the Small GTPase Rab15
… trafficking is a key mechanism for regulating receptor availability on\r\nthe plasma membrane as well as receptor degradation. Clathrin-dependent endocytosis\r\ninvolves receptor internalization into early endosomes. Here internalized receptors are\r\nsorted for degradation in lysosomes, direct …
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Targeting The Blood-Brain Barrier With A Non-Canonical Iron-Mimicry Mechanism
… and that a non-canonical association of (i) transferrin, (ii) the iron-mimic ligand motif, and (iii) transferrin receptor mediates binding and transport of particles across the BBB. We also show that in orthotopic human glioma xenografts, a combination of transferrin receptor over-expression …
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Characterization of the degradation of wild-type and mutant HFE proteins during stress signalling in the endoplasmic reticulum
… iron uptake by interacting with the Type 1 transferrin receptor and interfering with its ability to bind iron-loaded transferrin. There is also evidence that HFE regulates systemic iron levels by binding to the Type II transferrin receptor although the mechanism by which this occurs is still …
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Molecular and cellular insights into iron regulation
… Iron overdose in Chinese hamster ovary-transferrin receptor variant (CHO TRVb1) cells resulted in increased hepcidin peptide secretion after 30 min and 2 hours (p<0.03) as well as 24 and 48 hours (p<0.01). Also, partial characterisation of the previously unknown CHO-gene sequences of …
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Survival Of Mycobacterium Avium Subspecies Paratuberculosis In The Pol
… the phagosomal membrane. The endosomal protein, transferrin receptor, and the lysosomal marker, lamp-1, were then immunostained with cy-5 conjugated secondary antibodies, and colocalization of bacteria with each marker was evaluated separately using confocal scanning laser microscopy (cslm). In …
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Iron and DHA in Relation to Early Cognitive Development
… liquid chromatography. ID was assessed by serum transferrin receptor (sTfR), serum ferritin (SF), and body iron (BI); DHA by median split. Bayley Scales of Infant Development Index II (BSID-II) Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI) at 18 months (n=191) were …
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Metabolic regulation in Phosphatase and tensin homologue (PTEN) null T cell lymphoma/leukaemia cells
… high rates of glucose, glutamine, leucine and transferrin uptake, and expressed constitutively high levels of CD71, the transferrin receptor, and CD98, the System L amino acid transporters. Moreover, PTEN-/- T cell lymphoma/leukaemia cells had high levels of mTORc1 activity. PTEN deletion …
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Association of maternal factors and iron deficiency anaemia in pregnant women attending antenatal care at Chongwe rural health centre in Chongwe district.
… Complete blood count was performed, and Soluble Transferrin Receptor levels were measured to assess anaemia and iron status, respectively. Data was analysed using SPSS software version 23. Results: The prevalence of anaemia was (39.1%) 88/225 out of which (9.1%) 8/88 presented with iron …
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Association of maternal factors and iron deficiency anaemia in pregnant women attending antenatal care at Chongwe rural health centre in Chongwe district.
… Complete blood count was performed, and Soluble Transferrin Receptor levels were measured to assess anaemia and iron status, respectively. Data was analysed using SPSS software version 23. Results: The prevalence of anaemia was (39.1%) 88/225 out of which (9.1%) 8/88 presented with iron …
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The Development of a Drug Delivery System Using Brain Endothelial Non-Antibody Binding Domains as Transport Carriers
… system (CNS) a challenging feat. Endogenous BCEC receptors such as transferrin receptor (TfR) have been proposed as exploitable targets for therapeutic payload transport into the CNS, and have been successfully targeted using monoclonal antibodies to deliver therapeutic molecules into the brains …
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A photonic crystal biosensor application for assessment of iron deficiency
… for detection of serum ferritin and soluble transferrin receptor (sTfR), biomarkers for iron deficiency, is presented. Two assay formats were explored in this research: 1) standard sandwich assay (SA) and 2) inverse sandwich assay (IA). For both of these formats, total analytical error was …
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Molecular responses of iron regulatory proteins to iron overload in human liver
… transiently transfected cells. Protein levels of transferrin receptor 2 (TfR2) were found to be upregulated in the liver of both untreated as well as treated HH patients, and correlated directly, irrespective of mutations in HFE, with the degree of transferrin saturation, reaching saturable levels …
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Dynamics of Alpha5 Integrin, Paxillin, and Alpha-Actinin During Formation and Disassembly of Adhesions in Migratory Cells
… recycling pathway, including the dye FM 4-64 and transferrin receptor staining. Paxillin organizes into dynamic complexes in areas of membrane activity and paxillin from older complexes dissipates in close temporal coordination with the formation of new ones. alpha-actinin binding stabilizes these …
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Kinetics and Intracellular Pathways Required for MHC Ii-Peptide Loading and Surface Expression of a Hapten-Protein Conjugate in Murine Macrophage
… the cell via the existing endocytic machinery in transferrin receptor positive compartments. These studies also suggested that a novel macrophage surface receptor specific for polyaromatic compounds affected the processing of the probe by increasing the concentration of the probe 100-fold relative …
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