Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Transfer Hydrogenation"”.
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Asymmetric Transfer Hydrogenation of Secondary Allylic Alcohols
… catalyzed tandem isomerization and asymmetric transfer hydrogenation reaction. This reaction is a one pot, two-step process, which utilizes the unique ability of a transition metal catalyst to effect a combined reduction of the C-C double bond and the carbonyl group in a selected class of …
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Small Molecule Activation Using Transfer Hydrogenation Catalysts
… amount of acid was found to promote the hydrogenation of 1 to 1H(H). The rate of hydrogenation of 1 was found to be dependent on the identity of the acid. It was found that acids with a pKa three orders of magnitude more acidic than [Cp*Ir(H2)(TsDPEN)] + (pKa = 13.88 in MeCN) resulted in …
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METAL CATALYSED TRANSFER HYDROGENATION, DEHYDROGENATION AND RACEMISATION OF AMINES
… fundamental mechanisms relating to asymmetric transfer hydrogenation (ATH) of imines and the transfer dehydrogenation and racemisation of secondary amines by Cp*Rh and Cp*Ir complexes. A series of 16-electron complex of the type Cp*M(XNC6H4NX’) (where M = Rh or Ir and X, X’ = H or Ts) have been …
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A Ratiometric Probe for Rapid Evaluation of Transfer Hydrogenation Efficiency
… Ir(III) complex with ratiometric response to transfer hydrogenation reaction, intended for better understanding and quantifying the Small-Molecule Intracellular Metal Catalysts (SIMCats) efficiency. Chapter 1 gives an introduction to luminescent probes, cyclometalated Ir complexes, transfer …
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Applications of Green Chemistry in Asymmetric Transfer Hydrogenation and Chiral Separations
… I report the first Ru-catalysed asymmetric transfer hydrogenation (ATH) of prochiral allylic alcohols. This reaction provides chiral secondary alcohols in excellent enantioselectivities and yield. This new reaction is much safer, more economical and environmentally friendly for the …
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Iridium Complexes for Intracellular Transfer Hydrogenation and Their Potential Biological Applications
Transfer hydrogenation is a transformation that has been studied for over 100 years and used widely in chemical synthesis. Although transfer hydrogenation can be performed by natural enzymes such as dehydrogenases, small-molecule intracellular metal catalysts (SIMCats) that are capable of …
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Quinoline-triazole half-sandwich iridium(III) complexes: Synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies
… were evaluated for their ability to facilitate transfer hydrogenation, by reducing β-nicotinamide adenine dinucleotide (NAD+) to NADH in the presence of hydrogen source, sodium formate. Through preliminary qualitative and quantitative cell-free experiments, it was found that the two most active …
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Exploring Simple Catalyst for Transfer Hydrogenation of Ketones and Photocatalytic Hydrogen Production Using Homogeneous Metal Complexes
Transfer hydrogenation has been recognized to be an important synthetic method in both academic and industrial research to obtain valuable products including alcohols. Transition metal catalysts based on precious metals, such as Ru, Rh and Ir, are typically employed for this process. This thesis …
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Design and modification of rhodium and iridium N-heterocyclic carbene complexes for asymmetric transfer hydrogenation and antimicrobial activity
… iridium NHC amino acid complexes for asymmetric transfer hydrogenation (ATH) of prochiral ketones. Iridium(I) bis-NHC complexes were found to undergo oxidative addition with a variety of alpha-amino acids, generating chiral iridium(III) complexes of the form Ir(NHC)2(aa)(H)(X) (aa = amino acid, X …
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Increasing the Stability and Turnover Number of a Highly Active Iron Catalyst for the Asymmetric Transfer Hydrogenation of Ketones
A highly active iron catalyst for the asymmetric transfer hydrogenation (ATH) of ketones was reported by the Morris group in 2013. This catalyst surpassed the activity of platinoid metals by reaching TOFs up to 200 per second, but the highest reported turnover number (TON) was only 6060. To compete …
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Synthesis and Application of Air-Stable Secondary Phosphine Oxide, Oxime, and Amine-Phosphine Palladium(II) Complexes in Transfer Hydrogenation and Cross-Coupling Reactions
… These catalysts efficiently facilitated the transfer hydrogenation of benzophenone. The active species is believed to be a three- or four-atom palladium cluster resulting from decomposition of the palladium-oxime complex.
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Design and Modification of Half-Sandwich Ir(III), Rh(III), and Ru(II) Amino Acid Complexes for Application in Asymmetric Transfer Hydrogenation Reactions
… carboxylate), and their utility as asymmetric transfer hydrogenation catalysts of ketones. Variation of the metal center, the n-ring, and the aa was used to tune these systems for specific sets of ketones. Upon reaction with homochiral]s, the ligand environment in all of these complexes is …
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Expedient access to C-aryl linked saturated heterocyclic motifs
… the development of a one-pot Suzuki-Miyaura-hydrogenation was explored. This method was found to be highly general and tolerant of a wide range of functionalities. Scheme 1: Developed Suzuki-Miyaura-hydrogenation methodology [Figure available in print copy]. Subsequently, the methodology was …
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Application of Density Functional Theory to Study the Mechanism of Alkali Metal Enolate Oxidation by N-sulfonyloxaziridines, Umpolung Amide Synthesis from Halo-Amino-Nitro Alkanes, Alkali-Metal Catalyzed Transfer Hydrogenation of Ketones, and Asymmetric Catalyzed Aza-Henry Reactions
… (3) alkali (Li+, Na+, and K+) metal-catalyzed transfer hydrogenation of acetophenone, the mechanism of which was found to proceed via a six-membered transition state affording direct hydrogen transfer to acetophenone generating the product phenylethanol. The TMEDA ligand had a profound effect …
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Cooperative activation of biomass-derived oxygenates with Lewis acid zeolites
… are shown to effectively catalyze the coupled transfer hydrogenation and etherification of 5-(hydroxymethyl)-furfural with primary and secondary alcohols into 2,5-bis(alkoxymethyl) furans, thus making it possible to generate renewable fuel additives without the use of external hydrogen sources …
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Rational design and synthesis of zeolite acid catalysts for applications in biomass conversion
… zeolites. A detailed kinetics study compares transfer hydrogenation activity of Ti-, Sn-, Zr-, Hf-containing BEA zeolites with different hydrogen donors. A new characterization method using trimethylphosphine oxide probes and NMR is created to deduce structure-activity relationships. Finally, …
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