Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Transdermal drug delivery"”.
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Microneedle-mediated transdermal drug delivery of biotherapeutic macromolecules
… The complex molecular structure of these drugs render them susceptible to degradation and, as a result, many commercially available products are suitable for parenteral drug delivery only. Subsequently, the hypodermicneedle and syringe has remained the device of choice for biotherapeutic …
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Polymeric microneedle systems for enhanced transdermal drug delivery
Conventional drug delivery methods, such as oral and parenteral have many problems that may be potentially overcome by advanced drug delivery methods like enhanced transdermal drug delivery. Delivery across skin offers many advantages compared to oral or parenteral routes e.g. non-invasive, …
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Ultrasound-mediated transdermal drug delivery : mechanisms and applications
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.
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A controllable, nano-volumetric, transdermal drug delivery device
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2002.
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Linker-based Lecithin Microemulsions as Transdermal Drug Delivery Systems
The interest in microemulsions as transdermal delivery systems have been motivated by their large surface area for mass transfer, their high solubilization capacity of hydrophobic actives, and their ability to improve skin penetration. Lecithins (mixtures of phospholipids similar to those find in …
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Diffusivity of drug actives in transdermal drug delivery (TDD)
Transdermal Drug Delivery (TDD) through skin patches has many advantages including the following: slow and continuous administration of the therapeutic over long periods of time, timely dosage, accessibility, kinetic maneuverability, elimination of the "First Pass Effect" and negative side effects …
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Biophysical aspects of transdermal drug delivery and chemical enhancement
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.
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Development and formulation of wax-based transdermal drug delivery systems
Topical and transdermal formulations are promising platforms for the delivery of drugs. A unit dose topical or transdermal drug delivery system that optimises the solubility of drugs within the vehicle provides a novel dosage form for efficacious delivery that also offers a simple manufacture …
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Use of physical enhancers for gastrointestinal and transdermal drug delivery
… represents a significant advance in the field of transdermal- and gastrointestinal (GI)-based drug delivery. With regards to the former, previous work has led to a thorough mechanistic understanding of ultrasound (US)-enhanced transdermal drug delivery. Despite these investigations, it was …
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Experimental strategies for investigating passive and ultrasound-enhanced transdermal drug delivery
Transdermal drug delivery offers many advantages over traditional drug delivery methods. However, the natural resistance of the skin to drug permeation represents a major challenge that transdermal drug delivery needs to overcome in a safe and reversible manner. One method for enhancing transdermal …
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Optimisation of microneedle array design for microneedle mediated iontophoretic transdermal drug delivery
In order to exploit the transdermal route for systemic delivery of a wide range of drug molecules, including peptide/protein molecules, a means of overcoming the excellent barrier properties of the uppermost layer of the skin, the stratum corneum must be sought. It has recently been suggested that …
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Theoretical and experimental investigations of passive and ultrasound-enhanced transdermal drug delivery
… both the transient, and the steady-state, transdermal transport of hydrophilic permeants through unbranched, aqueous pore channels. This new transport model, combined with dual radiolabeled diffusion experiments, was then used to separately evaluate how the porosity, the tortuosity, and the …
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New screening methodology for selection of polymeric materials for transdermal drug delivery devices
… the selection of a precise and affordable drug delivery technology is seen as the most practical solution for governments, health care professionals, and consumers. Transdermal drug delivery patches (TDDP) are one of the best economical technologies that are favored by pharmaceutical …
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DEVELOPMENT OF MICRONEEDLES ON FLEXIBLE SKIN PATCH WITH FUNCTIONAL COMPONENTS FOR TRANSDERMAL DRUG DELIVERY APPLICATIONS
… with various configurations and functions for transdermal drug delivery applications. Here we developed a very unique technology called drawing lithography for the assembly of SU-8 and maltose sharp tips at the final step of the fabrication process, which is compatible with most of the …
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A Meshless Approach to Computational Pharmacokinetics
… and efficiency. The pharmacokinetic problem of transdermal drug delivery (TDDD) is one such topic and is of significant complexity. The locally collocated meshless method (LCMM) is developed in solution to this topic. First, the meshless method is formulated to model this transport phenomenon …
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Biophysical Techniques of Transcutaneous Drug Sampling and Drug Delivery
Monitoring the time course of drug in the skin is critical for determining the frequency and dose of drug administration from safety and efficacy perspectives. Intermittent blood sampling is used as a surrogate for approximating concentration of drugs in the tissues, which leads to blood loss and …
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Experimental and theoretical investigation of the effects of low-frequency sonophoresis on transdermal drug transport
Transdermal drug delivery offers many advantages over traditional drug administration methods such as injections and oral delivery, including increased patient compliance, and avoiding first-pass effects. However, due to the low skin permeability, transdermal drug delivery is currently limited to …
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Instrumentation to characterize needle insertion into biological tissue
The Transdermal Drug Delivery Project in the BioInstrumentation Laboratory involves the design of a device to deliver drugs through the human skin using micro needles. It is crucial to characterize the insertion of micro needles into biological tissues. Hence, instrumentation will be designed and …
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Design and evaluation of hot melt extruded transdermal patches.
… has been a growing interest towards the use of transdermal drug delivery systems (TDDS). However, a great challenge in this arena is the formidable barrier posed by the skin that can limit permeation of therapeutic agents. Therefore, there is a need for novel strategies or enhancement techniques …
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Development of dissolving and hydrogel-forming microneedles for delivery of vancomycin hydrochloride
… tract. As a consequence, utilising a novel transdermal drug delivery system to deliver vancomycin could prove a promising alternative. One approach that can be used to enhance transdermal drug delivery is microneedle (MN) technology. MN is micron-sized needles on a solid backing or support …
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