Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Transdermal delivery"”.
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Transdermal delivery of heavy chain only antibody binding domains using hydrogel-forming microarray patches
… the oral, pulmonary and ocular routes. However, transdermal delivery of HCAbs has yet to be examined. Therefore, this thesis explores the transdermal delivery of both VNARs and Nanobody® molecules using hydrogel-forming microarray patches (MAPs). Using this MAP technology, both HCAbs could …
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Novel Delivery Systems For Iron Replenishment
… along with other patient noncompliance issues. Transdermal delivery of iron could be a potential alternative to treat iron deficiency due to safety and offers more acceptability. Since conventional iron formulations are not suitable for transdermal delivery, quest for an ideal iron compound …
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Formulation, characterisation and topical application of oil powders from whey protein stabilised emulsions
… has been performed on oil powders for topical delivery. The aim of this project was to investigate the release characteristics of oil powder formulations, as well as their dermal and transdermal delivery properties. Whey protein-stabilised emulsions were used to develop oil powders. Whey …
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Microneedle-mediated transdermal drug delivery of biotherapeutic macromolecules
… products are suitable for parenteral drug delivery only. Subsequently, the hypodermicneedle and syringe has remained the device of choice for biotherapeutic delivery, despite the many drawbacks associated with this method. Transdermal delivery has been an attractive alternative for many …
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Transdermal Iontophoretic Delivery Of Lipophilic Drugs
… widely studied active technique for enhancing transdermal delivery of drugs. However, its ability to enhance the delivery of highly lipophilic compounds is poor due to lack of any charge and poor water solubility of molecules. Propofol, a sedative and anesthetic drug was chosen as a one of the …
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Optimisation of microneedle array design for microneedle mediated iontophoretic transdermal drug delivery
In order to exploit the transdermal route for systemic delivery of a wide range of drug molecules, including peptide/protein molecules, a means of overcoming the excellent barrier properties of the uppermost layer of the skin, the stratum corneum must be sought. It has recently been suggested that …
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Linker-based Lecithin Microemulsions as Transdermal Drug Delivery Systems
The interest in microemulsions as transdermal delivery systems have been motivated by their large surface area for mass transfer, their high solubilization capacity of hydrophobic actives, and their ability to improve skin penetration. Lecithins (mixtures of phospholipids similar to those find in …
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Colloidal microgels as (trans)dermal drug delivery systems
… drug carriers (i.e. a novel controlled drug delivery system) for either dermal or transdermal delivery. The experiments conducted in this project were, firstly, to investigate the uptake and release of model compounds with different physico-chemical properties (i.e. solubility and logKoct/w) …
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Experimental strategies for investigating passive and ultrasound-enhanced transdermal drug delivery
Transdermal drug delivery offers many advantages over traditional drug delivery methods. However, the natural resistance of the skin to drug permeation represents a major challenge that transdermal drug delivery needs to overcome in a safe and reversible manner. One method for enhancing transdermal …
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QSAR modeling of chemical penetration enhancers using novel replacement algorithms
The applications of transdermal delivery are limited because of the resistance of the skin to drug diffusion. Only potent drugs, with molecular weight less than 500 Da, are suitable to cross the skin barrier. Chemical Penetration Enhancers (CPEs) are used to promote the absorption of solutes across …
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Engineering a microneedle patch for opioid overdose therapy
… and complications associated with conventional delivery methods. In this work, we developed a minimally invasive microneedle (MN) patch system using gelatin methacryloyl (GelMA) hydrogels to enable sustained transdermal delivery of naloxone. Microneedle arrays (10×10, 600 µm height, 500 µm …
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Investigations on Nanomaterials For Potential Biomedical Applications
… include, but are not limited to, drug delivery, in vitro diagnostics, in vivo imaging, therapy techniques, biomaterials, and tissue engineering. A variety of organic/inorganic nanomaterials and devices are currently being investigated world over for these purposes. In this thesis we …
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Biophysical Techniques of Transcutaneous Drug Sampling and Drug Delivery
… techniques were developed for enhancing the transdermal delivery of drugs. “ChilDrive”, a technique of combining regional cutaneous hypothermia with iontophoresis was used for enhancing the bioavailability of transdermally administered drug in the deeper musculoskeletal tissue like synovial …
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Hydrogels for dermal applications
… hydrogel behaviour to modify topical and transdermal delivery capability and investigated the possibility of using monomer combinations that would influence the release characteristics of gels by modifying their hydrophobic and ionic nature. The copolymerisation of neutral monomers …
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InsulPatch: A Slim, Powerless Microfluidic Patch-Pump for Insulin Delivery
… deliver through an oral pathway and that require transdermal delivery. The patch-pump is a promising replacement for conventional syringes and battery-powered pumps because it is slim, powerless, painless, and relatively inexpensive. The majority of this thesis focuses on the fabrication and …
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Formulation and preparation of niosomes containing bioactive compounds
… vesicular systems as nanocarriers in dermal and transdermal delivery, RSV was incorporated into niosomes and liposomes and its ex-vivo percutaneous absorption in newborn pig skin was investigated using Franz diffusion cells. Cholesterol was also added as membrane stabilizer. The influence of …
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Synthesis and functionalisation of metal and metal oxide nanoparticles for theranostics
… was coated onto SPIOs and mixed into a gel for transdermal delivery using porcine skin. An NMR profile of the skin using a 0.25T NMR MOUSE® before and after application of the gel showed that after an incubation period of 2 hrs the CPP-SPIOs had penetrated the skin leading to a reduction in …
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Low-Frequency Sonophoresis Assisted Cancer Immunotherapy
… invasive, FDA approved technique for the transdermal delivery of lidocaine. Significant research has been carried out on its applicability for transdermal drug delivery. However, there are only a few reports on its use for cutaneous immunization (CI), and these have focused on induction of …
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Novel Biomimetic Polymeric Nanoconjugates as Drug Delivery Carriers for Poorly Soluble Drugs
… nanoconjugate present a novel tool for the delivery of ibuprofen with potential application for transdermal delivery.
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