Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Transcriptomics and Proteomics"”.
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Modeling And Identification Of Differentially Regulated Genes Using Transcriptomics And Proteomics Data
… dissertation we utilize various computational and modeling techniques to analyze transcriptomics and proteomics data sets from several photosynthetic organisms. We try to use changes in expression levels of genes to study responses of these organisms to various environmental conditions such as …
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Adaptive Mechanisms of an Estuarine Synechococcus based on Genomics, Transcriptomics, and Proteomics
Picocyanobacteria are important phytoplankton and primary producers in the ocean. Although extensive work has been conducted for picocyanobacteria (i.e. Synechococcus and Prochlorococcus) in coastal and oceanic waters, little is known about those found in estuaries like the Chesapeake Bay. …
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The Influence of Preovulatory Estradiol on Uterine Transcriptomics and Proteomics Around Maternal Recognition of Pregnancy in Beef Cattle
… play a crucial role in pregnancy establishment and maintenance, but the mechanism by which estradiol exerts its effects has not been well characterized. Specifically, the interactions between the maternal uterine environment and the developing conceptus can greatly impact pregnancy success or …
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Development and application of mass spectrometry-based metabolomics methods for disease biomarker identification
… rising incidence of metabolic disease, and increasing antibiotic resistance. These problems involve complex interactions between genes and environment and are often not well understood. To address these challenges, high-throughput and reproducible advances in genome sequencing, …
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An Integrated Omics Approach to Define the Molecular Mechanisms of Low Dose, High Charge, High Energy Irradiation (HZE) in Liver
… composed of protons (85%), helium (14%), and high charge-high energy ions (HZE) such as 56Fe, 28Si, and 16O. Humans are normally not exposed to HZE ions but will be exposed during deep space travel such as upcoming missions to Mars and the dark side of the moon. Exposure to HZE is a major …
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The role of post-transcriptional regulators in pathogenesis and secondary metabolite production in Serratia sp. ATCC 39006.
… bacterium that is virulent in plant (potato) and animal (Caenorhabditis elegans) models. It produces two secondary metabolite antibiotics, prodigiosin and a carbapenem, and the plant cell wall degrading exoenzymes, pectate lyase and cellulase. A complex regulatory network controls production …
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Scalable Machine Learning Methods For The Analysis Of Single-Cell Transcriptomics And Multiomics Data
Transcriptomics and proteomics-based expression profiling technologies have become increasingly popular, more affordable, and more accurate in recent years. Expression profiling of expression at the single-cell resolution allows investigators to identify rare cell subtypes in human tissue which …
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RNA sequencing for the study of splicing
… for the study of transcriptome composition, and have enabled further characterisation of such mechanism. In this thesis, I focus on the application of this technology to the study of human transcript diversity and its potential impact on the protein repertoire. In the first results chapter, I …
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Computational Modeling of Planktonic and Biofilm Metabolism
… are ubiquitously able to live in both planktonic and biofilm states, which can be applied to dissolve the energy and environmental issues (e.g., producing biofuels and purifying waste water), but can also lead to serious public health problems. To better harness microorganisms, plenty of studies …
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Algorithms for modeling and simulation of biological systems; applications to gene regulatory networks
… focused on developing a system-level understanding of biological systems. In the last decade advances in genomics, transcriptomics and proteomics have gathered a remarkable amount data enabling the possibility of a system-level analysis to be grounded at a molecular level. The …
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ESTABLISHING IN VITRO INTESTINAL EPITHELIAL CELL MODELS IN TRANSLATIONAL ANIMAL NUTRITION
… omega-3 polyunsaturated fatty acids (n-3 PUFA) and citrus pectins (CPn) are reported to beneficially affect the host intestinal immunity. However so far, the biological pathways modulated by these nutrients in intestinal inflammation at the level of intestinal epithelial layer (IEL) remains …
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Characterisation of lipoproteins in staphylococcus aureus
… of causing a wide range of hospital-acquired and community-acquired infections, and is becoming increasingly virulent and resistant to antibiotics. In order to investigate this pathogen, various methods have been used to analyse the pathogenic behaviour including genomics, transcriptomics and …
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Novel Statistical Methods for Mediation Analysis with High-dimensional Omics Mediators
… in high-throughput omics profiling technologies and large-scale epidemiology consortia, such as the Trans-Omics for Precision Medicine (TOPMed) program from the National Heart, Lung and Blood Institute (NHLBI) and UK Biobank, now has resulted in an extensive accumulation of genomic data for …
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OMICS APPROACHES FOR OMEGA-6/OMEGA-3 POLYUNSATURATED FATTY ACID RATIO IN PIGS
… influenced by fatty acid (FA) composition and intramuscular fat, which is mostly dependent on the dietary fat intake of pigs, but it is also affected by genetic variants. In this PhD thesis, we elucidated the effects of dietary lipids, in terms of omega-6 (n-6)/omega-3 (n-3) polyunsaturated …
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Developing molecular genetic tools for gene discovery in soybean (Glycine max)
… valuable crops grown worldwide for seed protein and oil production and can fix atmospheric nitrogen. The completed genome sequence and the availability of transcriptomics and proteomics data for genomic and physiological studies have made soybean a feasible model legume plant. The soybean genome …
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An omics study into the molecular impact of autosomal dominant APP and MAPT mutations on the cerebral cortex
Familial Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are characterised by an age of onset typically between 30 and 50 years of age and are often linked to autosomal dominant mutations. This dissertation focuses on APP and MAPT mutations causal to early onset AD or FTD, which affect …
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Investigating normal human gene expression in tissues with high-throughput transcriptomic and proteomic data.
… the transcriptome with RNA sequencing (RNA-Seq), and others probe the proteome with unlabelled bottom-up Mass Spectrometry. As the sampling of undiseased tissues is difficult, the community often refers to expression atlases, which are collating these studies, to support or validate new findings. …
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Differential Dependency Network and Data Integration for Detecting Network Rewiring and Biomarkers
… techniques enabled large-scale genomics, transcriptomics, and proteomics-based biomedical studies, generating an enormous amount of multi-omics data. Processing and summarizing multi-omics data, modeling interactions among biomolecules, and detecting condition-specific dysregulation using …
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Analysis of the genome organization and fitness traits of non-pathogenic Escherichia coli strain Nissle 1917 (O6:K5:H1)
… increases our knowledge on the genome structure and plasticity, as well as on the microbial diversity and evolution. In parallel, these data are the basis for the scientific “revolution” in the field of industrial and environmental biotechnology and medical microbiology – diagnostics and therapy, …
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Studies on the architecture and on transferability of pathogenicity islands of uropathogenic Escherichia coli strain 536
… Since then more than two hundred prokaryotic and eukaryotic genomes have been completely sequenced, and there are additional complete genome projects including different bacterial species and strains in progress (http://www.tigr.org, http://www.sanger.ac.uk). The continously growing amount of …
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