Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Transcriptional regulations"”.
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Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
… and cycloheximide blocking experiments or transcriptional mechanisms other than by Snail repression using luciferase reporter assays. My results indicate that RKIP is a relatively stable protein, which has a half-life around 1 to 2 days and is not subject to rapid degradation by …
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Degradational and Transcriptional Investigations of the RAF Kinase Inhibitory Protein
… and cycloheximide blocking experiments or transcriptional mechanisms other than by Snail repression using luciferase reporter assays. My results indicate that RKIP is a relatively stable protein, which has a half-life around 1 to 2 days and is not subject to rapid degradation by …
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Transcriptional Regulation of Matrix MetalloProteinase-3 in Rat Brain Astrocytes.
… are tight regulated by several steps including transcriptional regulation. Transcription factors, NF-？？B, Ets and activator protein (AP)-1 are reported to be involved in transcriptional regulation of MMPs. Here we demonstrated transcriptional regulations of MMP-3 in LPS-, IFN？^-, and …
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Dissecting Transcriptional Regulatory Networks with Systems Biology Approaches
… is focused on understanding these mechanisms of transcriptional regulation using systems biology approaches. Transcription regulatory networks play an important role in mediating external stimuli and coordinating responses to changing environments. Different methods that infer regulatory …
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Investigating the transcriptional regulation of BCL11A in Triple-negative Breast Cancer
… is known about how BCL11A is regulated at the transcriptional level in breast cancer. To tackle this problem, this project implements a novel proteomic approach utilising the Clustered regularly interspaced short palindromic repeats – CRISPR associated 9 (CRISPR-Cas9) technology, to identify …
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Systems analysis of Crassulacean acid metabolism (CAM) physiology and molecular biology
… the focus to explore a more upstream level of regulations at the level of gene expression. The second result chapter presented the Gene Regulatory Network Inference of *Kalanchoe fedtschenkoi* (Chapter 3). This chapter identified potential transcriptional regulators on different functional …
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Tracing RNA biography: in situ transcriptome profiling by novel spatial omics technologies
… delineate the spatially resolved post-transcriptional regulations within transcriptomes, studying these events at the single-cell and single-molecule level. This advantage is important for mapping the complex network of transcriptional and post-transcriptional gene regulatory mechanisms …
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Microfluidic Technology for Low-Input Epigenomic Analysis
… profiling. First, I examined RNA polymerase II transcriptional regulation with microfluidic chromatin immunoprecipitation followed by next generation sequencing (ChIP-seq) assays. Second, I probed the temporal dynamics in the DNA methylome during cancer development using a transgenic mouse model …
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Chemistry and Biology of DNA-protein cross-links
… contributes to epigenetic signaling, transcriptional regulations and chromatin remodeling. After the discovery of 5fC-mediated DNA-histone crosslinks in mammalian cells, we investigated their effects on DNA replication in Chapter III. DNA substrates containing site-specific DPCs were …