Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 642 for “"Transcriptional regulation"”.
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Albumin Transcriptional Regulation
… involved in maintaining the liver specific transcriptional profile of the rat and mouse serum albumin genes. Using DNA transfection and recombinant viral infection, the minimal rat promoter and mouse enhancer elements were identified, functionally dissected and shown independently to be …
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Transcriptional Regulation Of Adipocyte Function
… of adipocytes. While adipocyte development and transcriptional processes are well studied in vitro, regulation of in vivo genes (such as leptin), the identity of the adipocyte progenitor cells and the development of the adipose organ have not been defined invivo. In this thesis, firstly KLF4 was …
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Transcriptional regulation of mosquito oogenesis
… Distinct differences exist between the transcriptional regulation of <i>Ae. triseriatus</i> and <i>Ae. aegypti</i> oogenesis. TOR and many other proteins with previously unknown function are transcriptionally regulated during apoptosis and autophagy in mosquito ovaries during …
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Post-transcriptional regulation of IgE
… Arbeit wird die postranskriptionelle Regulation der Expression von IgE im Vergleich zu anderen Isotypen untersucht. Das mRNA Expressionsmuster beider Formen der schweren Kette von IgE, s-epsilon (sekretorisch) und m-epsilon (membranständig), unterscheidet sich von dem Expressionsmuster …
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Computational Analysis of Transcriptional Regulation
… process that is subject to multiple layers of regulation. Key features of this are the three-dimensional (3D) chromatin organisation of eukaryotic genomes and the post-transcriptional control of RNA fates. Eukaryotic nuclear DNA is tightly packaged as chromatin that is further folded into …
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Biomolecular Condensates in Transcriptional Regulation
Transcriptional regulation of gene expression is fundamental in determining cell behavior, identity, and organism development. When dysregulated it can cause disease. Core to transcriptional regulation is the control of RNA polymerase II (RNAPII) activity. The combined activity of DNA regulatory …
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Genome organization in transcriptional regulation
Transcriptional regulation of gene expression plays critical roles in the control of cell identity, development, and disease. Genome organization contributes to transcriptional regulation in multiple ways. At a fundamental level, the genome is organized into distinct active and repressive chromatin …
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Transcriptional regulation in Corynebacterium glutamicum
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Transcriptional regulation and genome structure
The regulation of gene expression is fundamental to the control of cell identity, development and disease. The control of gene transcription is a major point in the regulation of gene expression. Transcription is regulated by the binding of transcription factors to DNA regulatory elements known as …
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Transcriptional Regulation of Cardio-Pulmonary Development
… in dHAND mutants. TRAPs are a family of transcriptional co-activators that are required for normal cardiac and embryonic development. Mice lacking Btf showed normal cardiac development, however, the animals had hypercellular lungs and died within 24 hours after birth. Analysis of lung …
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Transcriptional regulation of adipose insulin resistance
… profiles. There is increasing awareness that transcriptional control is a source of dysregulation as well as an avenue of therapeutic intervention for insulin resistance. However, knowledge of transcriptional regulation and dysregulation of adipose insulin resistance remains fragmentary. Here, …
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Transcriptional and Post-Transcriptional Regulation of Retroelements
… mechanisms in place to restrain retroelements. Transcriptional silencing of retroelements is mainly achieved by heterochromatinization and DNA methylation. Our lab has demonstrated that p53 can also transcriptionally repress retroelements, however, the mechanism by which p53 mediates repression …
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Transcriptional Regulation of NLRC4 Inflammasome by IRF8
… our data highlights the role of IRF8 as a transcriptional regulator of NAIPs for NLRC4 inflammasome activation.</p>
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Transcriptional Regulation of the Xenopus MyoD Gene
… program is very well understood. However, the transcriptional regulation of the MyoD gene itself has not studied in Xenopus. In this thesis, I have analyzed the transcriptional regulatory mechanism of the MyoD gene in Xenopus by different approaches, which include transgenic reporter analysis …
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Transcriptional regulation of the inducible orphan nuclear receptornur77.
Transcriptional regulation of the inducible orphan nuclear receptornur77.
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Oncogene-driven post-transcriptional regulation in lung cancer
… multi-omic methods to interrogate the regulation of gene expression and protein abundance in oncogenic KRAS and RIT1 cells. Quantitative proteomic and transcriptomic profiling revealed that both mutant KRAS and mutant RIT1 promoted canonical Ras signaling, and overexpression of …
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Transcriptional regulation of the human tryptophan hydroxylase gene
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Transcriptional regulation of the Human Zfm1/Sf1 Gene
… aufrecht zu erhalten und geben Hinweis, dass die Regulation der globalen Transkription durch Zfm1 auch beim Menschen den zellulären Phänotyp (mit-) bestimmt.Weiterführende Experimente mit Decoy-Oligonukleotiden (dODN) gegen die Transkriptionsfaktoren EGR-1 und SP-1 zeigten, dass beide Proteine be …
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Transcriptional Regulation Mediated by Human Papillomavirus E2 Protein
… new cases are reported annually. In HPVs, regulation of gene expression is mainly controlled by virus-encoded E2 proteins which act as sequence-specific DNA-binding proteins in concert with host cellular transcription factors. Using reconstituted cell-free transcription systems, cellular …
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