Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Transcriptional interference"”.
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Genetic and biochemical analysis of the Drosophila melanogaster homolog of the human SCA2 gene
… neurodegeneration via mechanisms involving transcriptional interference. While transcriptional interference may account for pathology in some of the polyglutamine disorders, increasing evidence indicates that unique nuclear and non-nuclear pathways are involved in the different polyglutamine …
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Extra-Transcriptional Effects of Chromatin Bound RNA Polymerase III Transcription Complexes
… aids the assembly of TFIIIB to upstream of the transcriptional start site. Upon binding, Pol III is recruited near start sites and transcription of tRNA genes is initiated. Apart from transcription of a gene, these bound Pol III complexes influence transcription, chromatin state and genome …
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THE CHARACTERIZATION OF BEHAVIORAL ABNORMALITIES IN BDNF LOXP TRANSGENIC MICE
… presented by our data are produced by LoxP site transcriptional interference within the BDNF transcript. To support our hypothesis, future research should include quantification of BDNF expression, histological analysis of muscle spindle fibers, and cell counts of sensory and motor peripheral …
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THE MOLECULAR AND BEHAVIORAL CHARACTERIZATION OF THE MURINE CRE – LOXP SKELETAL MUSCLE SYNTHESIZED BDNF KNOCKOUT MODEL
… inhibition (PPI), which may be explained by transcriptional interference induced by the introduction of the LoxP sites. This thesis evaluates both molecular and barbering-related behavioral effects of BDNF floxing in transgenic mice generated using HSA-Cre/LoxP technology. Molecular analysis …
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Targeted Delivery of Surface Modified Nanoparticles: Modulation of Inflammation for Acute Lung Injury
… exert their anti-inflammatory effects by NF-kB transcriptional interference mechanisms. Besides the above inflammatory mechanisms, leukocyte migration is another hallmark feature responsible for part of ALI pathogenesis. Leukocyte migration is dictated by sequential activation of adhesion …
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The epigenetics and role of Dopa Decarboxylase in heart development
… silencing Ddc_exonla on the maternal allele via transcriptional interference. Ddc_exonla codes for the Dopa Decarboxylase (Ddc) protein, which is predominately expressed in the developing myocardium, this points to a role in fetal heart development. The role of Ddc in cardiogenesis is explored …
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OperomeDB: database of condition specific transcription in prokaryotic genomes and genomic insights of convergent transcription in bacterial genomes
… to contribute to the regulation of genes at both transcriptional and post-transcriptional levels, although factors contributing to their abundance across genomes and mechanistic basis for their prevalence are poorly understood. In this study, we explore the role of various factors contributing to …
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Assessing the Impacts of Silver Nanoparticles on the Growth, Diversity, and Function of Wastewater Bacteria
… mechanism of inhibition appears to be a post-transcriptional interference of AMO/HAO by either dissolved Ag or ROS, in treatments where membranes are not completely disrupted but nitrite production decreased (2 ppm GA AgNP and 2 ppm PVP AgNP treatments). The disruption of nitrification is …