Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Transcriptional gene regulation"”.
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Diverse RNA processing pathways important for post-transcriptional gene regulation
… regions (UTRs) of mRNAs are crucial to the regulation of gene expression. Animal microRNAs (miRNAs) each target hundreds of mRNAs, which are recognized by pairing to nucleotides 2-7 of the miRNA. MicroRNAs mature through sequential RNase III cleavage of characteristic stem-loop precursors. …
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Competition and band-pass filtering in biology: modelling and experimental validation in membrane trafficking and post-transcriptional gene regulation
L'abstract è presente nell'allegato / the abstract is in the attachment
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Leveraging high-throughput datasets for studies of gene regulation
… methods on biological data to better understand gene regulation and development of the human body, as well as of the model organisms mouse and yeast. Firstly, I tackled biological questions with machine learning techniques by studying pre-transcriptional gene regulation through nucleosome …
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Hormonal regulation of microRNA expression in the ovary
… the circle of life can be reproduced for future generations. The ovary is also responsible for producing, secreting, and maintaining the proper hormone milieu of estrogens and progesterone for maintenance of pregnancy and the overall fitness of a woman's health. Understanding the mechanisms that …
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Gene network understanding and analysis
Gene regulatory network (GRN) is a collection of regulators that interact with each other in the cell to govern the gene expression levels of mRNA and proteins. These regulators can either be DNA, RNA, protein and their complex. Transcriptional gene regulation is an important mechanisms in which an …
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Relationship between Processing Body Formation, Epithelial-to-Mesenchymal Transition, and Invasion in Lung Adenocarcinoma
… which are essential during metastasis. Many transcriptional gene programs are altered during EMT such as activation of mesenchymal transcription factors, like ZEB1, and enhanced response to the TGFβ1 cytokine. In oncogenic contexts, TGFβ1 enhances the formation of processing-bodies (P-bodies) …
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Polyaseeker: a computational framework for identifying polyadenylation cleavage site from RNA-seq
… (APA) of mRNA plays a crucial role for post-transcriptional gene regulation. Recently, advances in next generation sequencing technology have made it possible to efficiently characterize the transcriptome and identify the 3'end of polyadenylated RNAs. However, no comprehensive bioi nformatic …
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RNA Localization and Translational Regulation on the Endoplasmic Reticulum
… cellular mechanism for the spatiotemporal regulation of protein expression and serves important roles in oogenesis, embryogenesis, cell fate specification, and synapse formation. Signal sequence-encoding mRNAs are localized to the endoplasmic reticulum (ER) membrane by either of two …
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Stochastic modelling of gene regulation with microRNAs
… studies of microRNAs, a novel class of gene regulators, discovered relatively recently, is a rapidly growing field. In particular, researchers are focusing on identifying the targets of microRNAs and the roles of microRNAs in post-transcriptional gene regulation; the work presented in …
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mRNA localization in Caenorhabditis elegans embryogenesis
… specification to regulating protein output, post-transcriptional regulation of mRNA is essential for life. As a result, many mechanisms underlying post-transcriptional regulation are highly conserved across the kingdoms of life. As the spatial resolution of microscopy and sequencing assays has …
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Functions of Deadenylation Factors In Mrna Decay and Mrna Processing Body Formation
… also termed deadenylation, is important for post-transcriptional gene regulation, because deadenylation not only leads to mRNA translational inhibition but also is the first step of major mRNA degradation. Translationally inhibited mRNAs can be stored and/or degraded in dynamic cytoplasmic foci …
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Concentration-dependent Splicing through Suboptimal Motifs Enables Waves of Gene Regulation in Neuronal Development
… splicing, which occurs in over 95% of human genes, is the process by which exons are differentially included in transcripts produced from the same gene to produce a variety of transcript isoforms. This mode of post-transcriptional gene regulation endows the 20,000 protein-coding genes in the …
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Systems Biology Approaches to Probe Gene Regulation In Bacteria
… the host are not the product of isolated genes, but instead emerge from the concerted operation of regulatory networks. Therefore, identifying components and the systemic behavior of networks is necessary to a better understanding of gene regulation and pathogenesis. To this end, I have …
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Small non-coding RNA-mediated epigenetic regulation of gene expression and its implications for wheat adaptation to continuous cultivation
… wheat production. This yield decline is generally attributed to the interaction of abiotic and biotic soil stress factors as well as plant adaptation to long-term monoculture systems. However, the underlying molecular mechanisms have not yet been adequately explained. Against this …
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Microscopic characterization of a putative ER-membrane targeted Puf RNA-binding protein in Arabidopsis thaliana
… the functional units that participate in post-transcriptional gene regulation activities. One group of RBPs that plays an important role in regulating cytoplasmic post-transcriptional control is the Puf family of RNA-binding proteins. Some of the general characteristics of plant Puf proteins, …
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The synthesis and in vivo evaluation of chemically modified siRNAs that contain red-shifted internal azobenzene derivative spacers for selective and tunable photocontrol of activity without UV light
… (siRNAs) are biopolymers that are used for post-transcriptional gene regulation and act as endogenous defenses against attack from viruses and dsRNA parasites. The siRNA field is making advances for use as pharmaceuticals and biomolecular research tools for the study of gene silencing in …
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Transcriptional and Post-Transcriptional Regulation of Nodule-Specific Gene Expression in Soybean
… based on morphological similarities and genetic studies, but gene expression profiles during the formation of these organs have not been compared. In addition, the role of post-transcriptional gene regulation during nodule development has not been thoroughly explored. Bridging these …
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THE EPITRANSCRIPTOMIC REGULATION OF STRESS: ROLE OF N6-METHYLADENOSINE IN ABIOTIC STRESS RESPONSE
… stress is their ability to regulate appropriate gene expression, both transcriptionally and post-transcriptionally. Covalent modifications of ribonucleotides within the RNA molecules, also known as the epitranscriptome, have recently emerged as an important aspect of post-transcriptional gene …
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Quantification of microRNA regulation and its consequences at the single cell level
… RNAs which play important roles in post transcriptional gene regulation. miRNAs regulate more than half of mammalian protein-coding genes. They have been found to participate in almost every cellular process and their dysregulation is associated with many diseases. miRNAs recognize their …
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