Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Transcriptional factor"”.
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Genetic interaction landscape of the Escherichia coli transcriptional factor machinery
In Bacteria, transcription factors (TFs) consist of sensory ligand-binding and DNA-binding helix-turn-helix (HTH) domains to respond to the environmental and internal stimuli. Although Escherichia coli is a well-studied model bacterium, yet half of its TFs’ characteristics remain unclear, including …
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Functional characterization of the role of Imp, a Drosophila mRNA binding protein, during oogenesis
… polarity requires the involvement of several posttranscriptional regulatory mechanisms, including mRNA localization and translational control. A family of highly conserved RNA binding proteins in vertebrates, VICKZ (V̲g1RBP/V̲era, I̲MP-1, 2, 3, C̲RD-BP, K̲OC, Z̲BP-1) proteins, has been shown to …
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HAPLOINSUFFICIENCY OF RAI1 AND ITS EFFECT ON BDNF EXPRESSION
… deletion [10]. RAI1 is thought to function as a transcriptional factor although its cellular role is still unclear. First, in order to better understand the role of RAI1 as a transcriptional factor and its relation to SMS, we confirmed that RAI1 regulates BDNF within an intronic region. This …
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THE ROLE OF DMP1 IN HUMAN BREAST CANCER PROGNOSIS AND CYCLIN D1-INDUCED BREAST CANCER
Dmp1 is a transcriptional factor that directly binds and activates the Arf promoter. It is also a bona fide tumor suppressor that is activated by oncogenic Ras and HER2 signalings and in turn stimulates the Arf-p53 tumor suppression pathway. Dmp1 physically interacts with cyclin D1 that is …
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Dual Assembly Nanoparticles Achieve Sustained Silencing of Znf304: A Novel Transcription Factor For Β1 Integrin
… validation identified a novel zinc finger transcriptional factor 304 (ZNF304) as one of the key factors for ovarian cancer metastasis. High tumoral ZNF304 expression was associated with poor overall survival in ovarian cancer patients. Through reverse phase protein array analysis, we …
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Ceramide-Induced Alternative Translocation of TM4SF20
… Regulated Intramembrane Proteolysis (RIP) of the transcriptional factor CREB3L1 (cAMP response element binding protein 3-like 1), a transcription factor synthesized as a membrane-bound precursor. CREB3L1 RIP is induced by several stimuli: ER stress, viral infections, the chemotherapeutic drug, …
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Genetic Improvement of Switchgrass Cell Wall Content, Leaf Angle and Flowering Time
… population. We overexpressed an Arabidopsis NAC transcriptional factor gene, LONG VEGETATIVE PHASE ONE (AtLOV1), in switchgrass. Surprisingly, AtLOV1 induced smaller leaf angle by changing morphologies of epidermal cells in the leaf collar region, affecting lignin content and monolignol …
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14-3-3 Zeta Overexpression Serves As A Novel Molecular Switch Turning Tgf-Beta From Tumor Suppressor to Tumor Promoter
… stabilizing Gli2, which is an important co-transcriptional factor for p-smad2 to activate PTHrP expression and bone osteolytic effect. Taken together, we reveal a novel mechanism that 14-3-3ζ dictates the tumor suppressor or metastases promoter activities of TGF-β signaling pathway through …
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Development of drug screening assays for identification of new molecules against pancreatic ductal adenocarcinoma
The yes-associated protein, YAP, is a transcriptional co-activator, able to regulate the expression level of a wide range of target genes. Despite deregulation of YAP has been associated with cancer etiology, no compounds are known to specifically modulate its functions. Here we identified an …
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The regulation of denitrification in P. denitrificans
… genes were co-regulated by CPR/FNR type transcriptional regulators. Motif analysis of the upstream region showed similar patterns recognizable by FNR. P. denitrificans expresses three FNR type regulators that could potentially compete for cognate site binding. Three mutant strains of …
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Novel Small-RNA Mediated Gene Regulatory Mechanisms for Long-Term Memory
… synaptic facilitation through regulation of the transcriptional factor CREB1 and translation factor CPEB respectively. We therefore provide the first evidence that a modulatory neurotransmitter important for learning can regulate the levels of small RNAs and present a novel role for miR-124 and …
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Epigenetic regulation of genes related to lipid metabolism by microrna in mice fed high fat diet
… predicted several potential transcription factors of miR-29 family members that suppress the expression of miR-29s. At mRNA level, some of these transcription factors, c-Myc and EZH2, were significantly activated in response to HF diet. The present results indicated that the LPL expression …
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Innate Immune Transcription Activator Interferon Regulatory Factor-3 (IRF3) Contributes to Maladaptive Remodeling Post-myocardial Infarction
… and overall survival. While the well-known NF-κB transcriptional factor that is downstream to TLR4 signaling has been linked to remodeling, there has been no evidence thus far describing a role of the parallel interferon regulatory factor-3 (IRF3) signaling cascade in any facet of this process. …
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The stimulatory role of ICOS in the development of CD146+CCR5+ T cells co-expressing IFN-γ and IL-17 during graft-versus-host disease
… Our data also showed that inhibiting the major transcriptional factor of Th17, RAR-related orphan receptor gamma t (RORγt), could prevent the development of CD146+CCR5+ Tconvs in vitro. Our results demonstrate how pathogenic CD146+CCR5+ T cells are induced through ICOS or RORγt, suggesting new …
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Toll like Receptor 4-Mediated Immune Responses in the Bladder Epithelium
… sequentially, Ca2+, AC3 generated cAMP, and the transcriptional factor CREB. This capacity of BECs to mobilize secondary messengers and evoke a more rapid IL-6 response might be critical in their role as first responders to microbial challenge in the urinary tract. </p><p>Here, we also report two …
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Lesioni degenerative e meccanismi di riparo della superficie oculare: lo pterigio e le deficienze delle cellule staminali del limbo (LSCD). Studio immunoistochimico e tecniche di coltura cellulare
… Besides this “classical role”, it can act as transcriptional regulator in response to external stimuli that may lead to cell damage and tissue remodeling. Due to this role, it can be internalized into the nuclear compartment to act as transcriptional factor for proteins involved in the …
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Overexpression of Heat Shock Factor 1 Protects against Pathological Proteins in Neurodegenerative Diseases
… death. HSPs are regulated by a stress-induced transcriptional factor, heat shock factor 1 (HSF1). HSF1 is inactive when in complex with HSP90 and becomes active once it is released from this interaction in the presence of misfolded proteins. Studies have shown that levels of multiple HSPs are …
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Regulation of milk fat synthesis by dietary fatty acids
… the expression of lipogenic transcription factor (TF) SREBP-1C. Potential roles of the TF ChREBP, PPARG, and INSIG1 were also established. A subsequent study aimed to establish whether these mechanisms operated in lactating dairy cows. Compared with un-infused controls and a t10c12 CLA …
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The mechanisms regulating the transcription factor ATF5 and its function in the integrated stress response
Phosphorylation of eukaryotic initiation factor 2 (eIF2) is an important mechanism regulating global and gene-specific translation during different environmental stresses. Repressed global translation by eIF2 phosphorylation allows for cells to conserve resources and elicit a program of gene …
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Identification and Characterization of Transcriptional Regulatory Elements for Liver-Specific Expression of Rabbit CYP2C Genes
… element is a binding motif of a liver-enriched transcriptional factor hepatocyte nuclear factor 4 (HNF-4), since it was recognized by a nuclear protein with the same tissue distribution, DNA binding specificity and immunochemical reactivity as those of HNF-4. The CYP2C2 promoter-luciferase …
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