Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"Transcriptional activator"”.
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Coordinated of Post-Translational Modifications of Yeast Transcriptional Activator Gcn4
Gcn4 is a transcriptional activator that regulates amino acid biosynthetic genes in yeast. Gcn4 is expressed under amino acid starvation conditions, and its degradation depends on phosphorylation, by either Pho85 or Cdk8, which triggers its ubiquitination and subsequent proteolysis by 26S …
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Localization and Stability of the Transcriptional Activator Gcn4p of Saccharomyces cerevisiae
Die `Allgemeine Kontrolle der Aminosäurebiosynthese` der Hefe Saccharomyces cerevisiae ist ein gut charakterisiertes regulatorisches Netzwerk, welches die ausreichende Aminosäureversorgung des Organismus gewährleistet. Dieses System wird durch Stimuli wie beispielsweise Aminosäuremangel, …
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Targeting a Transcriptional Activator Induces Changes in Large-Scale Chromatin Structure and Nuclear Positioning
This study addresses the relationship between transcriptional activation and large-scale chromatin structure and nuclear positioning. We have used an artificial system to target large amounts of the very strong viral transcriptional activator, VP16, to specific chromosome sites. The rationale of …
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Genetic analysis of RNA polymerase/transcriptional activator interactions at thepepT promoter of S. typhimurium
… subunit of RNA polymerase (encoded by rpoA) in transcriptional activation by the global regulatory protein FNR has been investigated using a genetic approach. We have identified five rpoA mutations which decrease the FNR-dependent anaerobic induction of the pepT gene of S. typhimurium. Each of …
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Rational development of novel small molecule leads against the transcriptional activator protein ExsA of Pseudomonas aeruginosa
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen. It is present in aquatic, marine, and soil environments and can also be found in a variety of anthropological environments, including water distribution systems and hospitals. This prevalence is concerning due to P. aeruginosa’s …
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Placental co-transcriptional activator Vestigial-like 1 (VGLL1) drives tumorigenesis via increasing transcription of proliferation and invasion genes
<p>Vestigial-like 1 (VGLL1) is a co-transcriptional activator that binds to TEA domain containing transcription factors (TEADs). Its expression is upregulated in a variety of aggressive cancer types, including pancreatic and basal-like breast cancer, and increased transcription of VGLL1 is strongly …
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Regulation of nitrogen fixation in Klebsiella pneumoniae: NifL, one protein transducing two environmental signals to the nif-transcriptional activator NifA
Klebsiella pneumonia moduliert NifL die Aktivität des Transkriptionsaktivators NifA in Abhängigkeit der Umweltsignale Stickstoff und Sauerstoff. NifL ist ein Flavoprotein, welches das Sauerstoffsignal wahrscheinlich durch einen redoxsensitiven Konformationswechsel transduziert. Wir haben die …
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Mechanistic Studies of the Roles of the Transcriptional Activator ExsA and Anti-activator Protein ExsD in the Regulation of the Type Three Secretion System in Pseudomonas aeruginosa
… transcription factor family, is the main transcriptional activator of all the genes necessary for expression of the T3SS. Members of the AraC family are characterized by the presence of two helix-turn-helix (HTH) motifs, which bind to the promoter DNA and activate transcription. ExsA uses …
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Polyomavirus Enhancer Activator 3 (PEA3), a Member of the Ets Family of Transcription Factors, Is a Transcriptional Activator of Notch-1 and Notch-4 in Breast Cancer: An Opportunity for Novel Combinational Therapy
… overall survival. PEA3 (polyomavirus enhancer activator 3), a member of the Ets family of transcription factors, is overexpressed in triple-negative breast cancer and also correlates with aggressive behavior and poor overall survival. Here, we provide new evidence for transcriptional regulation …
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LDB-1 AND SWI/SNF CHROMATIN REMODELING COMPLEX PARTICIPATE IN THE TRANSCRIPTIONAL ACTIVATION BY C. ELEGANS BLIMP1/PRDM1
… the human zinc finger and SET domain-containing transcriptional repressor BLIMP1/PRDM1. BLIMP1/PRDM1 and its orthologs are well studied as transcriptional repressors in many species including humans and mice. Interestingly, we found that in C. elegans, BLMP-1 acts as a direct transcriptional …
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EWSR1 and FUS fusion genes in tumorigenesis
… types. The EWSR1-POU5F1 chimera was a stronger transcriptional activator than wild-type (wt) POU5F1, analogous to other EWSR1 chimeras, and was able to activate transcription through a binding site which is normally recognized by POU5F1. In Article III, FUS-CREB3L2 was found to be a stronger …
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The Regulation of NAP4 in Saccharomyces cerevisiae
<p>The CCAAT binding-factor (CBF) is a transcriptional activator conserved in eukaryotes. The CBF in Saccharomyces cerevisiae is a multimeric heteromer termed the Hap2/3/4/5 complex. Hap4, which contains the activation domain of the complex, is also the regulatory subunit and is known to be …
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Protein kinase A-dependent phosphorylation and degradation of CDK8 : implications for yeast filamentous growth
… work showed that Cdk8p phosphorylated a key transcriptional activator of the filamentous response, Ste12p, and subsequently targeted the factor for degradation under conditions of limiting nitrogen. Data presented in this thesis suggests that Cdk8p is regulated by another kinase, Tpk2p. In …
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HISTONE LYSINE METHYLTRANSFERASE NSD3 GOVERNS TRANSCRIPTIONAL PROGRAMS THAT DRIVE PANCREATIC NEUROENDOCRINE TUMORS (PANNETS)
… that H3K36 methylation by NSD3 functions as a transcriptional activator accelerating tumorigenesis in PanNETs. Additionally, we established a novel genetically engineered mouse model (GEMM) for PanNETs focused on the top inactivating mutations observed in human disease. Lastly, we have …
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Molecular and biochemical characterization of thevp12 mutant of maize (Zea mays L.)
… In addition, transcripts corresponding to vp1, a transcriptional activator for embryo ABA-mediated responses, were also observed in mutant embryos. Therefore, it can be suggested that the ABA signal transduction pathway is not impaired in vp12 embryos.
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Characterization of the Ets-family transcription factor Ets98B in Drosophila
… cells suggest that Ets98B can function as a transcriptional activator. In the future it will be interesting to further explore the phenotypes associated with loss and overexpression of Ets98B and explore the possibility of connections to signaling pathways. In order to further explore the …
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Characterizing interactions between cAMP responsive element binding protein 1 and methyl-CpG-binding protein 2 as a potential transcriptional activation complex
Transcriptional activity is controlled by many types of DNA binding proteins. In addition to transcription factors that activate transcription by recruitment of RNA polymerase II, there are proteins like methyl-CpG-binding protein 2 (MeCP2). MeCP2 regulates transcription by binding to methylated …
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Vestigial-Like 1 Is A Shared Targetable Cancer-Placenta Antigen Expressed By Pancreatic and Basal-Like Breast Cancers
… HLA-A*0101 restricted peptide derived from co-transcriptional activator Vestigial-like 1 (VGLL1), a novel putative TAA demonstrating overexpression in multiple tumor types and low or absent transcript expression in normal tissues with the exception of placenta. VGLL1-specific CTL isolated and …
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Is there an association between S1P signaling and the transcription factor Nrf2?
… 2 [NF-E2]-related factor 2 (Nrf2) is a transcriptional activator that can offer protection to cells. By activating cytoprotective genes, Nrf2 can help cells to defend against DNA damage, electrophilic and oxidative stress. However, Nrf2 can also act as an oncogene. The upstream mutation …
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