Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Transcriptional Units"”.
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Inferring condition specific regulatory networks with small sample sizes: a case study in bacillus subtilis and infection of mus musculus by the parasite Toxoplasma gondii
… in synthetic biology and found examples of transcriptional units active only under a subset of conditions, this information can be useful when designing circuits to have condition dependent behaviour. We developed methods for large network decomposition that made use of the condition …
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Functional large non-coding RNAs in mammals
… of actively transcribed genes to define discrete transcriptional units that do not overlap any known proteincoding genes. Using this approach we identified -3,500 transcriptional units in the human and mouse genomes that produce multi-exonic RNAs that lack any coding potential. We termed these …
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Quantitative analysis of translational coupling in Escherichia coli
… mRNA transcript in bacteria. These multi-gene transcriptional units, called operons, are widespread in bacteria with nearly half of all annotated genes predicted to reside in them. How operons affect translational regulation is still not known. There is a phenomenon specific to operon, so …
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Characterization of a transcriptional response to population density in Bacillus subtilis
… leads to changes in expression of at least 35 transcriptional units; nine of them appear to be directly regulated by ComA. Many of the operons encode genes that affect the membrane and extracellular environment. The signaling pathway positively regulates transcription of genes involved in fatty …
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Scaling up Genetic Circuits in Mammalian Cells: A U1-snRNA-based Platform Enables Mammalian Cells to Compute the Bitwise Inversion of the Square Root of a Number
… Operates (through) RNA), which does not use any transcriptional regulators or exogenous proteins, which can cause dangerous immune responses. The design of this sophisticated logic circuit was found by executing an algorithm, which I developed, for the exhaustive search of logic circuits designs …
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The regulation and two genes in Bacteroides thetaiotaomicron starch utilization system
… that sus structural genes are regulated at the transcriptional level, and their expression is induced by maltose. We report here the identification and characterization of a gene, susR, which appears to be responsible for maltose regulation of the sus structural genes. The deduced amino acid …
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Spliceosomal small nuclear ribonucleoprotein particle trafficking and maturation in the nuclear compartment
… Contrary to the current paradigm, the co-transcriptional recruitment of splicing snRNPs to nascent transcripts is not contingent on their role in splicing in vivo. Based on these and other data, we have constructed a two-step recruitment-loading model wherein snRNPs are first recruited to …
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Silencing the host : the role of intronic microRNAs
… intergenic miRNAs are expected to be independent transcriptional units, intragenic miRNAs are commonly believed to be regulated through their host gene. Despite of the growing knowledge on how miRNAs integrate into cellular regulatory networks, our current knowledge about the specific role of …
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Characterization of Human Endogenous Retrovirus sequences identifed in the human genome using the RetroTector software
… than expected by chance into the 5 ́end of transcriptional units, mostly in antisense orientation. A few lncRNAs were also found to contain HERV sequences. Thus, cis-effects from HERVs are to be expected. In conclusion, this study represents an advance in the state-of-the art of HERV …
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Experimental Methods in Support of the Development of a Computational Model for Quorum Sensing in Vibrio fischeri
… lux genes are organized in two divergent transcriptional units: luxR and luxICDABEG. The latter contains the genes required for luminescence and the luxI gene necessary for synthesis of an N-acyl-homoserine lactone commonly called autoinducer (AI). The luxR gene codes for a transcriptional …
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Analysis of factors that affect parvovirus expression
… of which BPV is a member, contain two transcriptional units with promoters active in temporal order during infection. BPV proteins also appear in the same temporal order; the nonstructural (NS) proteins are produced before the capsid proteins. Northern blot analysis of BPV RNAs suggest …
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Frameworks for reprogramming early diverging land plants
Plant form is a product of emergent processes of cell division, patterning and morphogenesis. These fundamental processes remain poorly characterised in plants. However, engineering approaches can provide new tools and frameworks for the study and manipulation of plant development. This …