Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Transcriptional Regulatory Network"”.
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Dissecting the transcriptional regulatory network of embryonic stem cells
… is poorly understood. An understanding of the transcriptional regulatory networks that establish and maintain gene expression programs in mammalian cells is fundamental to understand development and should provide the foundation for improved diagnosis and treatment of disease. Although it is …
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Dissecting the Transcriptional Regulatory Network Underlying Plant Wound Suberin Biosynthesis
… suberin biosynthesis have been identified, the regulatory components controlling its biosynthesis and deposition are only now beginning to be deciphered. The overall objective of this dissertation is to decipher the transcriptional regulators of suberin biosynthesis with a particular emphasis on …
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The Arabidopsis thaliana Heat Shock Transcription Factor A1b Transcriptional Regulatory Network
… which include the initiation of complex transcriptional regulatory circuits. The heat shock transcription factors (HSFs) have been shown to be central regulators of plant responses to abiotic and biotic stress conditions. However, the extremely high multiplicity in plant HSF families …
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Understanding small RNA-mediated post-transcriptional regulation of Salmonella pathogenicity island 1 activator HilA in Salmonella typhimurium
… epithelial cells. Many environmental and regulatory signals control SPI1 gene expression, but in most cases, the molecular mechanisms remain unclear. Many regulatory signals control SPI1 at a post-transcriptional level, and we have identified a number of small RNAs (sRNAs) that control the …
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Analysis of the PROM algorithm as a tool to generate genome-scale metabolic-regulatory networks
… algorithm to generate genome--‐scale metabolic--‐regulatory networks, which accurately predict growth phenotypes of transcriptional regulatory mutants under various conditions. E. coli, M. tuberculosis and S. cerevisase were used as model organisms. We showed that PROM could be successfully …
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Quantitative dynamic modeling of transcriptional networks of embryonic stem cells using integrated framework of Pareto optimality and energy balance
… and mass balance constraints. Analysis of transcriptional regulatory networks and metabolic networks in ESCs thus requires both a nonequilibrium thermodynamic and mass balance framework for designing and understanding complex ESC network approach as well as an optimality approach which can …
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Structure and topology of transcriptional regulatory networks and their applications in bio-inspired networking
<p>"Biological networks carry out vital functions necessary for sustenance despite environmental adversities. Transcriptional Regulatory Network (TRN) is one such biological network that is formed due to the interaction between proteins, called Transcription Factors (TFs), and segments of DNA, …
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Role of the ubiquitin-proteasome pathway in the inner ear : identification of an E3 ubiquitin ligase for Atoh1
… is under the control of a Wnt and Notch transcriptional regulatory network to keep the level of mRNA within a narrow range. Once the protein is made, it activates its own expression through an interaction with the Atoh1 enhancer, such that Atoh1 transcription is self-perpetuating. Because …
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Nutrition, Hormones, Transcriptional Regulatory Networks and Division of Labor in Honey Bee Colonies
… nutritionally- and hormonally-driven changes in transcriptional regulatory networks in the fat bodies (as well in the brain), and I suggest methodologies for their elucidation. Finally, in Chapter 5, I utilize the molecular systems biology approach outlined in Chapter 4 to show that a …
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Systems Biology Approaches to Probe Gene Regulation In Bacteria
… instead emerge from the concerted operation of regulatory networks. Therefore, identifying components and the systemic behavior of networks is necessary to a better understanding of gene regulation and pathogenesis. To this end, I have developed systems biology approaches to study …
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Regulation and inhibition of pro-tumorigenic microenvironments
… regulated. Furthermore, identification of SASP regulatory pathways will identify targets for anti-cancer therapies aimed at inhibiting the pro-tumorigenic microenvironment. I have investigated the regulation of the SASP on several different levels. My work has uncovered a novel transcriptional …
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Selective targeting of MYC by antisense oligonucleotides
… the genome, the MYC oncoprotein coordinates a transcriptional regulatory network consisting of approximately 15% of all genes, controlling cancer hallmark expression programs responsible for cellular proliferation, growth, metabolism, and evasion from apoptosis. MYC dysregulation occurs …
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Identification of Deleterious and Disease Alleles in a General Population and Preterm Labor Patients
… genome-wide association studies and the transcriptional regulatory network. However, even in protein-coding regions, it is not well understood how often and by what mechanism deleterious alleles disrupting strong sequence conservation can become common in population frequency and affect …
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Regulation of Global Transcription Dynamics During Cell Division and Root Development
… computational techniques, to examine the role of transcriptional regulatory mechanisms in controlling the complex gene expression programs underlying two fundamental biological processes---the cell cycle and the development and differentiation of an organ.</p><p>We generate a dataset describing …
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The role of coordinated regulation and aromatic metabolites in activating the mar/sox/rob regulon of Escherichia coli
… the degree of genetic cross-talk between these regulatory systems and the cooperative role of these three transcriptional regulators in activating downstream targets. The overarching goal of this work is to provide an integrated model for the mar/sox/rob regulatory network. First, the role of …
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Computational analysis of regulatory networks using genome-scale data
… In single-celled organisms such as S. Cerevisiae regulatory networks respond to the external environment, optimizing the cell at a given time for survival in this environment. Thus a yeast cell, finding itself in a sugar solution, will turn on genes to make enzymes that process the sugar to …
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Identifying and modeling perturbed networks in cancer through statistical and constraint-based analysis
… work has focused largely on modeling biological networks—using both statistical and mechanistic modeling approaches—with applications to medicine, energy, and genomic science. The more coarse-grained of these approaches use statistical analysis of high-throughput expression data to identify …
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Bayesian Integration and Modeling for Next-generation Sequencing Data Analysis
… on weak binding signal detection. To infer cis-regulatory modules (CRMs) of multiple TFs, we propose to develop a Bayesian integration approach, namely BICORN, to integrate ChIP-seq and RNA-seq data of the same tissue. Each TFBS identified from ChIP-seq data can be either a functional binding …
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Novel Monte Carlo Approaches to Identify Aberrant Pathways in Cancer
… on two research topics: 1) identification of transcriptional regulatory networks and 2) uncovering of aberrant intracellular signal transduction pathways. We propose a robust method, called GibbsOS, to identify condition specific gene regulatory patterns between transcription factors and their …
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Cis-regulatory module analysis: inferring regulatory networks and underlying mechanisms
… and temporal expression of the genes. Cis- regulatory modules (CRMs/enhancers), main players of this regulatory process, are typically short (<1kb) sequences that are embedded in non-coding regions of the genome. They harbor cis-elements (binding sites/motifs) for one or more related …
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