Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Transcriptional Regulatory Mechanisms"”.
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Transcriptional Regulatory Mechanisms of Ribosomal Protein Genes
… has implicated the role of 26S proteasome in transcriptional regulation of the ribosomal protein genes tying protein degradation to protein synthesis pathway. To determine the mechanism as to how the 26S proteasome promotes transcription of the ribosomal protein genes a series of experiments …
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Characterisation of the potentially diverse transcriptional regulatory mechanisms of human coagulation PZ gene.
… The aim of this study was to investigate the mechanisms by which PZ expression is controlled at the level of transcription, including whether hormonal and/or inflammatory signals modify expression and, therefore, possibly account, at least in part, for the wide normal range.Bioinformatic …
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Regulation of gene expression and cell state in embryonic stem cells
… signaling pathways, which all contribute to a transcriptional regulatory circuitry. Embryonic stem (ES) cells are capable of self-renewal and can give rise to nearly all differentiated cell-types, making them an ideal system in which to address the challenges of understanding gene expression …
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Regulation of Global Transcription Dynamics During Cell Division and Root Development
… computational techniques, to examine the role of transcriptional regulatory mechanisms in controlling the complex gene expression programs underlying two fundamental biological processes---the cell cycle and the development and differentiation of an organ.</p><p>We generate a dataset describing …
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The Role of the ORB2 RNA-binding Protein in Post-transcriptional Regulation
… proteins (RBPs) are key components of the post-transcriptional regulatory framework and can determine the translational fate of their RNA targets. A wide variety of post-transcriptional regulatory mechanisms are employed during the early Drosophila embryo and it has been established as a system …
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Understanding transcriptional regulation through computational analysis of single-cell transcriptomics
Gene expression is tightly regulated by complex transcriptional regulatory mechanisms to achieve specific expression patterns, which are essential to facilitate important biological processes such as embryonic development. Dysregulation of gene expression can lead to diseases such as cancers. A …
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Precise Temporal Regulation of Ribonucleoprotein Complexes during the Drosophila Maternal-to-Zygotic Transition
… and localization of maternal mRNAs through post-transcriptional regulatory mechanisms. For example, in the Drosophila melanogaster embryo, the Smaug (SMG) RBP forms ribonucleoprotein complexes with corepressors, Trailer hitch (TRAL), Maternal expression at 31B (ME31B) and Cup, as well as AGO1 and …
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Molecular Mechanisms Underlying The Transcriptional Regulation of T Helper 17 and Regulatory T Cells
… by their cytokine profile and immune regulatory functions. These subsets include Th1, Th2, Th17, natural and inducible regulatory T cells (nTreg and iTreg respectively), among others. We focused our investigation on two Th lineages, Th17 and regulatory T cells, with opposing functions …
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Molecular characterization and transcriptional regulation of GCV3, the Saccharomyces cerevisiae gene encoding the H-protein of the glycine cleavage system
… highly regulated little was known about the transcriptional regulatory mechanisms that control its activity. To address this I have examined the transcriptional regulation of the S. cerevisiae GCV3 gene. The results presented here show that at least six different transcriptional activators …
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Harnessing transcriptomic data to better understand gene regulatory mechanisms of neurodevelopmental disorders
… in neurodevelopmental disorders (NDDs), yet the mechanisms by which their dysregulation impacts brain development remain unclear. Brain development depends on precisely timed, tightly regulated gene expression. This thesis investigates the nonsense-mediated mRNA decay (NMD) pathway —a key …
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Roles Of Neuregulin1 In Neuromuscular Junction Development
… were studied as a means to define the complex regulatory communication at the NMJ. Using the chicken embryo as a model, methods were developed to study the effects of NRG1 signaling on NMJ development in ovo using sequential, quantitative measures of NMJ formation including AChR cluster size …
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Inferring Transcriptional and Post-Transcriptional Network Structure by Exploiting Natural Sequence Variation
… to study genetic variation at the level of gene regulatory networks rather than individual genes. This thesis consists of four parts, each of which outlines a different strategy for integrating genome-wide expression data and genotype data in order to identify transcriptional and …
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The Role of Dax-1 in Regulating Pluripotency in mouse Embryonic Stem Cells
<p>The orphan receptor Dax-1 is highly expressed in pluripotent embryonic stem (ES) cells and shows a correlative reduction in expression as these cells differentiate. While it is known that Dax-1 is expressed in pluripotent mouse ES cells, the precise function of Dax-1 in these cells is not as …