Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Transcriptional Coactivator"”.
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Neuroprotection from the huntingtin-repressed transcriptional coactivator PGC-1α
The transcriptional coactivator PPARgamma coactivator 1alpha (PGC-1α) is a regulator of mitochondrial biogenesis and function and is decreased in the striatum of patients with Huntington’s Disease (HD). HD is an autosomal dominant neurological disorder caused by a polyglutamine repeat in the …
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Mechanism of Action of ING4 as a Transcriptional Coactivator of p53
… less defined window into ING4's effect on p53 transcriptional activity. Purification of the ING4 complex allowed verification of previously known subunits and identification of BRPF1/2/3 as a core ING4 component. Reconstitution of the ING4 complex allowed the identification of two distinct …
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The Dual Role of OCA-B in B Cell Development and Signaling
<p>OCA-B (Oct coactivator from B cells) is a B-cell specific coactivator of transcription that acts in conjunction with the ubiquitously expressed activator, OCT-1 or the B cell-restricted OCT-2. OCT-1 or OCT-2 can bind an upstream octamer element with the consensus sequence 5'-ATGCAAAT-3' in …
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Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… understood. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ or WWTR1), key players of the Hippo pathway, have been implicated in the liver fibrosis, but the HSC-specific functions of YAP and TAZ are largely unclear. Here we have identified Sirtuin 6 …
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Calcium/Calmodulin Dependent Protein Kinase Type-II Associates with Flightless-I to Influence its Nuclear Localization
… and capping protein that also functions as a transcriptional coactivator. The CaMK-II-Fli-I interaction was confirmed with endogenous (un-tagged) proteins. The association and localization of Fli-I are dependent on CaMK-II's activity state, although Fli-I is not a substrate of CaMK-II. When …
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On Sulfur Sensing in Saccharomyces cerevisiae
… two proteins; the F-box protein Met30, and the transcriptional coactivator Met4. Met30 belongs to the family of SCF (Skp1-Cul1-F-box protein) E3 ubiquitin ligases, and negatively regulates the transcriptional activity of the master transcriptional activator of sulfur metabolism genes, Met4, via …
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Controlling Gene Expression with Synthetic Molecules
… against CBP (CREB-binding protein), an important transcriptional coactivator, and three novel, low micromolar affinity ligands were isolated. A cellbased reporter gene assay was employed to assess the cell permeability and transcription activation potential of the synthetic ligands in live …
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Identifying Oncogenic Drivers of Poor Outcome in Triple Negative Breast Cancer
… effects of TGFβ2-pSMAD2/3 signalling towards transcriptional activation of EMT and metastasis driving genes. Furthermore, we identified this dysregulation occurs at the protein level with GLI2 requiring to interact with YWHAZ to partner with pSMAD2/3, to translocate to the nucleus where it act …
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Atrial arrhythmogenesis in a murine model of mitochondrial insufficiency
… a murine model with homozygous deficiency of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1 β (Pgc-1β-/-). Pgc-1β regulates mitochondrial biogenesis and function, and unlike other murine models of mitochondrial dysfunction Pgc-1β-/- mice have a mild …
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Examining the effect of CBP on the E2A-PBX1 and HOXB4 interaction
… and the CREB-binding domain (KIX) of the transcriptional coactivator CBP and demonstrated a requirement for this interaction in leukemia induction. Others have shown that HOX proteins and CBP also interact directly, with resulting inhibitory effects on the DNA-binding ability of HOX …
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The Hippo Signaling Pathway in Organ Size Control and Regeneraton
… a transcription complex consisting of the transcriptional coactivator Yorkie (Yki) and the TEAD/TEF family of transcription factor Scalloped (Sd) in Drosophila. The inhibition of Yki activity is through modulating its phosphorylation status and subcellular localization by upstream kinase …
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New Insights On The Role of Jmjd2A In Cancer Progression
… many studies have mainly focused on its role in transcriptional regulation, only recently, its non-enzymatic function has started to unveil, but the studies are scarce and inconclusive.</p> <p>In our study, we showed that JMJD2A is essential in mediating activation of the canonical Wnt/β-catenin …
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The Role of Histone H2B Ubiquitylation and its Related Factors in Transcriptional Regulation in Mammalian Cells
… and phosphorylation play important roles in transcriptional regulation throughout eukaryotes, and recent studies in yeast also have implicated H2B ubiquitylation in the transcription of specific genes. However, a systematic study of H2B ubiquitylation in mammalian cells has been hindered by …
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The Role of Hippo Signalling in Merlin Null Tumours of the Nervous System
… activity of yes-associated protein (YAP) and transcriptional coactivator with PDZbinding motif (TAZ), the co-transcriptional activators of the Hippo pathway in Merlinnull meningioma and schwannoma. Nuclear YAP and TAZ activate transcription, primarily by binding to the TEAD family of …
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Characterization of Transcription Factor-Coactivator Complexes in Acute Lymphoblastic Leukemia
… model in which E2A-PBX1 binds DNA, recruits transcriptional co-activators by means of the activation domains and induces ALL through deregulation of PBX1 target genes. This transcriptional control is, in part, mediated by the recruitment of the transcriptional coactivator CBP/p300. Indeed, …
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Studies of the Hippo Signaling Pathway
… which in turn phosphorylates and inactivates the transcriptional coactivator Yorkie (Yki). Phosphorylation of Yki restricts its nuclear localization through recruiting 14-3-3. When the activity of the Hpo/Wts kinase cassette is compromised, Yki forms complexes with transcription factors including …
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Characterising mechanisms of regulation of hypoxia-inducible factors.
… adapt to low oxygen stress (hypoxia) through a transcriptional response pathway mediated by the Hypoxia-inducible factor protein, HIF. HIF is a heterodimer consisting of one of three alpha subunits (HIF-1a, HIF-2a or HIF-3a) and a beta subunit called Amt. The activation of HIF by hypoxia is a …
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The role of microRNA-194 and microRNA-375 in prostate cancer metastasis
… of prostate cancer cells. I identified YAP1, a transcriptional coactivator and a potent oncogene, as a direct and biological relevant target of miR-375. Additionally, I demonstrated that miR-375 was under the direct transcriptional control of EMT-promoting factor, ZEB1. Collectively, these …
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Understanding the Molecular Basis for FGF15/19 and FGF21 Actions on Energy Homeostasis
… FGF15/19 inhibits expression of the transcriptional coactivator PGC1α, a key regulator of gluconeogenic gene expression. The repressive effect of FGF15/19 on gluconeogenic gene expression is lost when PGC1α is overexpressed. FGF15/19 causes the dephosphorylation and inactivation of …
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Control of Regulatory Element Function by Histone H3.3
… (PTMs). The histone variant H3.3 is enriched at transcriptionally active regulatory elements such as promoters and enhancers. While recent studies have revealed a role for H3.3 in silencing repetitive elements and repressing developmentally regulated promoters, it is unclear how H3.3 contributes …
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