Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Transcriptional Co-Activator"”.
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Mechanistic Control of The Coldinduced Augmentation of The Transcriptional Co-Activator PGC-1α
Cold water immersion is commonly used to alleviate the stress and damage that ensues following strenuous exercise. Alongside its purported performance and analgesic benefits recent literature highlights the positive impact it may have towards endurance adaptive responses, particularly on key …
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Identifying the Molecular Mechanism of TAZ-Induced Lung Tumorigenesis
The transcriptional co-activator with PDZ-binding domain (TAZ) is a transcriptional co-activator and downstream component of the tumor suppressor Hippo pathway that plays critical roles in organ size control, stem cell self-renewal, tumorigenesis and drug resistance. Recently, TAZ has been …
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The Regulation and Function of Drosophila Acinus
Autophagy and growth control are two processes critical to organisms that mutually antagonize and regulate on each other. Several well known connections between these processes have been described, but here I describe a new link. Using Drosophila melanogaster as a model system, my thesis research …
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Identifying Novel Interaction Between CDK8 Kinase Module and The Deubiquitinating Enzyme Ubiquitin Specific Protease 7 (USP7)
… thesis explores the role of USP7 in regulating components of gene expression regulators. The gene expression of target genes is fine-tuned by the transcriptional co-activator, the Mediator complex. Our group has determined that Cyclin Dependent Kinase 8 (CDK8) and Mediator Complex Subunit 12 …
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A Cell-Based Model to Study Factors that Drive Diffuse Astrocytoma Development
Secondary gliomas are an incurable form of brain cancer that are diagnosed in people at a median age of 45 years. Next-generation sequencing has found that secondary glioblastomas have a distinct genetic profile from the more common primary glioblastomas, which are diagnosed in people typically …
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Molecular Consequences of High Taz Expression In Gliomas
<p>Diffuse high grade gliomas are complex and lethal neoplasms of the adult central nervous system that are driven by a range of genetic and epigenetic alterations. Molecular classification of these tumors has identified different transcriptional subtypes, the most notable being Proneural (PN) and …
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Purification of SIMPL Antibody and Immunofluorescence of SIMPL Sub-Cellular Localization in Response to TNFα- and IL-1
SIMPL is a transcriptional co-activator that alters the activity of transcription factor, NF-κB. In response to pathogens, cytokines such as Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) signal through the IL-1 and TNF-α receptors, respectively, which are found on various cell types. …
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Development of drug screening assays for identification of new molecules against pancreatic ductal adenocarcinoma
The yes-associated protein, YAP, is a transcriptional co-activator, able to regulate the expression level of a wide range of target genes. Despite deregulation of YAP has been associated with cancer etiology, no compounds are known to specifically modulate its functions. Here we identified an …
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The inhibition of mammary epithelial cell growth by the long isoform of Angiomotin
Mammary ductal epithelial cell growth is controlled by microenvironmental signals in serum under both normal physiological settings and during breast cancer progression. Importantly, the effects of several of these microenvironmental signals are mediated by the activities of the tumor suppressor …
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Molecular Regulation of Mitochondrial Biogenesis in Exercised and Fasted Human Skeletal Muscle: an Examination of Emerging Regulatory Protein
The transcriptional co-activator PGC-1alpha is widely accepted as the “master regulator” of mitochondrial biogenesis – an increase in mitochondrial content – and much research has been devoted to understanding PGC-1alpha's role in mitochondrial remodeling. However, several studies have demonstrated …
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Combinatorial Roles Of Skeletal Cell Yap And Taz In Bone Growth, Remodeling, And Repair
… skeletal lineage cell responses require the coordinated activation of multiple transcriptional programs. As defective genetic regulation of bone formation leads to both developmental and metabolic skeletal diseases, identifying and characterizing novel transcriptional regulators of skeletal …
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Specificity protein 1 induces the expression of angiomotin in response to IL-6/STAT3 activation to mediate YAP-dependent growth of breast cancer cells
… the activity of signal transducers and activators of transcription 3 (STAT3), a transcription factor that has been extensively studied for its role in promoting breast cancer. Recently, downregulated HIPPO signaling was shown to drive the pro-growth effects of IL 6. Reduced HIPPO …
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The Interplay Between PGC-1 and Autophagy During Metabolic Alterations in Skeletal Muscle
PGC-1α is a transcriptional co-activator well established as a potent regulator of oxidative metabolism in skeletal muscle. This co-activator mediates metabolic adaptation to exercise by orchestrating mitochondrial biogenesis. PGC-1α is also integral for the maintenance of muscle mass and function …
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Taz As A Regulator of Mesenchymal Transformation and Clinical Aggressiveness In Gliomas
… This subset is associated with poor clinical outcome and resistance to treatment. To establish the molecular drivers of this mesenchymal transition, we correlated transcription factor expression to the mesenchymal signature and identified transcriptional co-activator with PDZ-binding motif (TAZ) …
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The role of SENSITIVE TO FREEZING6 in plant tolerance to stress
… of climate change predicts that plants will become subject to increasing extremes of enviro nmental stress. Rapid population increases in developing countries also demand higher yield from crop production, often from sub-optimal agricultural areas. Genetic engineering can help meet these needs …
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Investigating the Role of the PGF2 Alpha/Calcineurin-Signaling Pathway in the Regulation of Adipogenesis
… receptor as functionally important downstream transcriptional targets of the PGF2α/calcineurin-pathway involved in the inhibition of adipocyte differentiation. In the case of IL-11, we show that this cytokine acts in an autocrine fashion to inhibit adipogenesis via the essential actions …
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Defining mechanisms directing YAP/TAZ-mediated tumorigenesis
… activity of yes-associated protein (YAP) and transcriptional co-activator with PDZ binding motif (TAZ) (YAP/TAZ). Uncontrolled nuclear YAP/TAZ activity evokes tumor-initiating properties in a range of epithelial-derived cancers, including oral and breast cancers, but their downstream targets …
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The role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetes
… being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. The aim of this thesis was to explore the role of DNA methylation and common genetic variation …
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Determining Mechanisms by which Pathological Extracellular Matrix induces Ocular Hypertensive Phenotypes in Human Trabecular Meshwork Cells
… (IOP), the only treatable risk factor for glaucoma. Herein, two different glaucoma-relevant cell-derived matrices (CDMs) were used to dissect the specific mechanisms by which diseased ECMs may precipitate ocular hypertensive phenotypes in human TM (hTM) cells. Methods: (1) To determine whether …
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Metabolic Regulation of Gene Expression through Differential Histone Acylation: The Regulation and Function of Histone Crotonylation
… around histones and by recruiting effector complexes. Three major classes of proteins are associated with Kac, namely "writers," enzymes that covalently modify specific lysine residues, "readers," protein domains that specifically bind modified residues, and "erasers," enzymes that catalyze …
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