Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Transcription studies"”.
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In vitro transcription studies of adenovirus
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1983.
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Analysis of the roles of ligand and DNA binding in estrogen receptor action
… estrogen receptor (ER) is unable to activate transcription. Studies of Chinese Hamster Ovary cells which were grown under serum-free conditions, suggested that commercial base media may contain traces of estrogenic compounds. Additional studies demonstrated that transcriptional synergy by ER …
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Επίδρση της Ν.Ν.- Διμεθυλο - Νιτρωδοαμίνη στο μεταβολισμό του RNA σε ΜΥΕΣ C57BL
… WAS EXAMINED IN DETAIL. IN VIVO AND IN VITRO TRANSCRIPTION STUDIES INDICATED THAT IT WAS NOT DUE TO A DECREASE IN THE ACTIVITIES OF RNA POLYMERASES I AND IIOR AN ALTERATION IN THEIR BINDING TO CHROMATIN, BUT TO A REDUCED ACTIVITY OF CHROMATIN AS A TEMPLATE FOR TRANSCRIPTION. FURTHERMORE, THE …
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Analysis of methylation status of CGB genes in common nontrophoblastic cancer
… genes, CGB3-9. These genes are regulated via transcription factors AP2α, SP1, OCT3/4 and possibly DNA methylation. DNA methylation is a repressive mark found in cytosines in DNA. The aim of this study is to investigate the role of DNA methylation in relation to CGB3-9 genes activation and …
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Analyses of the MEC1 DNA Damage Pathway in Saccharomyces cerevisiae
… This study addressed two overarching themes of transcriptional and post-translational regulation within the MEC1 pathway. We first applied our understanding of the MEC1 DNA damage transcriptional response to develop advanced luciferase whole cell biosensors that could detect a broad range of …
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Transcriptional Regulation Mediated by Human Papillomavirus E2 Protein
… proteins in concert with host cellular transcription factors. Using reconstituted cell-free transcription systems, cellular enhancer-binding factors and general cofactors, such as TAFIIs, TFIIA, Mediator, and PC4, were found not to be required for E2-mediated repression. HPV E2 is able …
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A Study of TGF‐β Signaling in B Lymphocytes and Glioblastoma
… and p21<super>Cip1</super> transcription, studies from Smad3 null mice suggest that TGF–β–induced growth inhibition in B lymphocytes occurs regardless of Smad3 status. We prove that this response does indeed occur independently of Smad3 in purified primary B lymphocytes and …
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Characterization of the Sigma Factor Proteins and the Dna Binding Protein Euo of Chlamydia
… between the EB and RB forms. The goal of these studies was to explore two potential mechanisms that may function in regulating developmental cycle stage‑specific gene expression in chlamydiae: a cascade of sigma factor expression and the binding of the early stage protein EUO to DNA. </p> <p> …
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Mechanistic analysis of estrogen receptor action using dominant negative mutants
… acids directly involved in ligand-dependent transcriptional activation have been mutated or deleted. Although they are still able to bind estrogen, these ER mutants are no longer able to activate gene transcription. While the non-hormone binding mutants NHB1 and NHB7 are less effective than …
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At Casey’s Altar – exploring the life and music of Bobby Casey
… ethnography, historiography, as well as musical transcription and analysis, this thesis presents the reader with a comprehensive study of Bobby’s character, life and creative process. Furthermore, the repertory nature of this study, culminating in the form of a transcribed tune collection, not …