Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Transcription start site"”.
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Prediction of Dna Methylation Based On Genomic Architecture and Applications of Positional Weight Matrices
… on retrotransposon elements surrounding the transcription start site, plays an important role in the suppression and promotion of DNA methylation. In our investigation we found a high rate of SINE and LINEs retrotransposon elements near the transcription start site of unmethylated genes when …
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Regulation of the glpFK operon of Escherichia coli K-12 and characterization of it gene products
… N-terminal amino acid analysis identified the startpoint of translation for the gipK gene. The transcription start site was identified 71 base pairs upstream from the proposed translation start codon for glpF. Preceding the transcription start site were -10 and -35 sequences Similar to the …
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Action at a distance for specific repression of the glpD and glpTQ genes, and organization of the glpEGR genes of Escherichia coli K-12
… -10 promoter element and 30 bp downstream of the transcription start site. The glpACB-glpTQ operons operons are controlled by GlpR binding to operators that overlap the glpA promoter elements. In this study, two additional operators were identified within the glpD structural gene, and three …
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Transcriptional Regulation of Chicken Apolipoprotein A-I Gene Expression
… nucleotides −311 to +19 upstream of the apoA-I transcription start site. Biochemical analysis of functional domains of v-Jun indicates that DNA binding specificity of vJun and its ability to heterodimerize with diverse partners are absolutely required for repression of apoA-I transcription. …
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Role of RIP3 in DNA damaging agent-induced breast cancer cell death
… cell lines due to DNA methylation near its transcription start site. Due to this silencing mechanism, loss of RIP3 expression in these cells leads to resistance to DNA damaging-agents. Hypomethylating agents restore RIP3 expression and promote sensitivity not only to death receptor ligands, …
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Upstream conserved sequence element that regulates TIM-3 induction in CD4+ T cell
… find DNA region involved in regulation of TIM-3 transcription in human CD4+ T cells between -70 kbp to -1 bp from the TIM-3 transcription start site. Given that regulatory DNA regions show nucleotide sequence homology between species, four conserved non-coding sequences (CNS -29, CNS -53, CNS -56 …
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Inhibition of IFN-[gamma] promoter function by site-specific methylation
… CpG located at the -53 position relative to the transcription start site. Methylation at this position inhibits c-Jun, ATF2 and CREB binding in vitro. Consistently, the same factors bind to the unmethylated promoter in a TH1 cell line, but not the methylated promoter in a TH2 cell line. …
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Characterization of a potato Proteinase Inhibitor II gene whose expression in not wound-responsive
… that of pin2K from -767 to +29, relative to the transcription start site of the wound-inducible pin2K. The 5[superscript]' flanking region of pin2T was linked to the reporter gene (chloramphenicol acetyl transferase, CAT; or [beta]-glucuronidase, GUS) coding sequences in constructions that …
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Comparative analysis of the promoters of the CyI-CyIIa-CyIIb actin gene cluster in the sea urchin Strongylocentrotus purpuratus
… region of CyIIa upstream of the ATG and putative transcription start site was subcloned and sequenced. Sites of protein-DNA interaction were identified using DNaseI footprinting. Comparisons of this data with that previously obtained for CyI and CyIIb showed that while CyI and CyIIb share an …
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Sculpting 3d Chromatin Folding Via Genome Editing
… domain boundary—containing a CTCF binding site (CBS) and a transcription start site (TSS)—into 16 ectopic loci across 11 chromosomes, and characterized its architectural impact. Depending on local constraints, this fragment variably formed new domains, partitioned existing ones, altered …
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Signaling Pathway Inhibitor Library Screening Reveals B-Catenin/TCF4 as a Novel Telomerase Regulator in Cancer cell lines
… the screen and was later found to inhibit TA via transcription regulation of hTERT (human TERT). Activation of the Wnt pathway either by Wnt ligand (Wnt-3a) or LiCl (activates Wnt signaling by inhibiting GSK-3?) treatment as well as overexpression of a constitutively active form of ?-catenin (?-N …
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The Generation of Alternative Transcripts as a Means of Regulating Phosphorylation in Sonic Hedgehog Medulloblastoma
… phosphorylation events selectively. Co- and post-transcriptional mechanisms, such as alternative transcription start site (ATSS) usage and alternative splicing (AS), may generate isoforms that include or exclude exons harboring critical phosphorylation sites, offering a potential mechanism for …
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Genetic mapping and functional studies of a natural inhibitor of the insulin receptor tyrosine kinase: the mouse ortholog of human [alpha subscript 2]-HS glycoprotein
… bp subclone containing 154 bp upstream from the transcription start site, the first exon, and part of the first intron. A second genomic subclone harboring a 3.45 kb BgI II fragment contained exons 2, 3, and 4 in addition to two adjacent elements within the first intron-a repetitive element of …
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Chromatin Dynamics During DNA Replication
… Amongst the best studied of these is the transcription start site where it has been observed that genic nucleosome locations are well maintained with respect to promoters.<br/><br/>DNA and chromatin replication are coupled processes whereby chromatin is disrupted ahead of the replication …
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Cloning and Characterization of Replication Protein A from Dictyostelium discoideum
… most likely, proteolytic cleavage. The transcription start site for both sizes of DdRPA1 has been identified at 306 bp upstream of the coding sequence by primer extension reaction. A PCR fragment representing 27% of the gene encoding the DdRPA middle size subunit (DdRPA2) has been …
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Regulation of polycomb repressive complexes at the neural differentiation gene Pax6
… progenitors. Neural differentiation gene transcription begins in a sharply defined position due to loss of fibroblast growth factor (FGF) signalling. This highly coordinated onset of gene expression implies the involvement of a higher order mechanism to co-ordinately regulate hundreds of …
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Identification and characterization of farR and farE as a regulator and effector of fatty acid resistance in Staphylococcus aureus
… an uncharacterized member of the TetR family of transcriptional regulators, which is divergently transcribed from a gene encoding a member of the resistance-nodulation-division superfamily of multi-drug efflux pumps. I named these genes farE and farR, for regulator and effector of fatty acid …
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UNCOVERING LNCRNA-CHROMATIN INTERACTIONS SHAPING HUMAN MONOCYTE TO MACROPHAGE DIFFERENTIATION
… that combines long-reads sequencing with transcription start site mapping. This enabled the expansion of current annotations with a large repertoire of previously unannotated transcripts, many of which are highly cell-stage specific. We then mapped RNA-chromatin interactions genome-wide …
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Characterisation of the potentially diverse transcriptional regulatory mechanisms of human coagulation PZ gene.
… PZ expression is controlled at the level of transcription, including whether hormonal and/or inflammatory signals modify expression and, therefore, possibly account, at least in part, for the wide normal range.Bioinformatic analysis enabled the identification of two age stable elements (ASEs) …
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