Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Transcription inhibitor"”.
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Translation and transcription are required for endogenous bursting after long term removal of neuromodulators
… elimination of neuromodulators, translation inhibitors are tested on the recovery process of pyloric activity in C. borealis. In vitro experiments are conducted; the STG is exposed to the protein synthesis inhibitor Cycloheximide (CHX) and the transcription inhibitor Actinomycin D (ACD). The …
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Genomic and non genomic effects of elevated concentration of anabolic steroids in human neuronal cells
… cells. Treatment with actinomycin D (10-5M), a transcription inhibitor, revealed that nandrolone may regulate MOPr mRNA stability. In SH-SY5Y cells transfected with a human MOPr luciferase promoter/reporter construct, nandrolone did not alter the rate of gene transcription. These results suggest …
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Mechanism-Based Strategies to Enhance The Actions of A
… protein levels is due to the activation of the transcription factor HSF-1 binding to the promoter region of HSP70 and HSP27 genes. HSF-1 binding subsequently promotes HSP70 and HSP27 gene expression. Based on this, I hypothesized that inhibition of transcription/translation of HSP or client …
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A Structural and Biochemical Analysis of the Drosophila Protein Period
… clocks is the protein Period (PER), a circadian transcription inhibitor. The stable production, posttranslational modification, and nuclear translocation of PER all contribute to the timing of the clock. This work describes the synthesis and purification of various Drosophila PER fragments for …
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Regulation and function of interphase histone H1 phosphorylation in pluripotent cell differentiation
… processes including chromatin condensation and transcriptional regulation. Recent studies revealed changes in the expression and genomic distributions of H1 variants during cell differentiation which appear to contribute to phenotypic differences between cell types, but the functional …
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Investigations of cellular stress-responsive proteins and PGF gene expression in human trophoblast
… stress-mediate angiogenic responses include post-transcriptional regulation of mRNA stability, and regulation of PML sequestering protein. We investigate whether these mechanisms occur in hypoxic stressed trophoblast and preeclamptic placenta. Methods: To determine transcript stability, PGF mRNA …