Global ETD Search
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Showing 1 to 2 of 2 for “"Transcription hub"”.
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Understanding the role of the Notch intracellular domain in transcription hub formation
… insights into the role of NICD in promoting a transcription “hub” at target loci to promote transcription. A second goal was to manipulate the timing of activation and the levels of NICD to determine their impact on the transcriptional response. To achieve this, an optogenetic method was …
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Interpreting Notch signals: characterisation of dynamic transcription hubs by live imaging
… is not well understood. Additionally, CSL, the Transcription Factor cleaved Notch interacts with, has relatively short DNA residence times, contrasting with a much longer duration of gene transcription. There are gaps in our understanding of how Notch activation results in transcription complex …