Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Transcription factor proteins"”.
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Dynamics of Germ Cell Specific Stable Transcriptional Complexes in Xenopus Oocytes
… genes, and this often depends on the binding of transcription factors to genomic DNA sequences on which they act. This is particularly true of genes that determine cell fate; for example, Asc1-1 leads to neural differentiation and MyoD for muscle. In early development, different genes need to be …
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Understanding machine learning models of the epigenome with statistics and statistical mechanics
… modifications of DNA and its associated proteins which do not change DNA sequence. These modifications mark and package DNA in different ways and help to establish cell types, which are distinct and heritable gene expression states. Understanding determinants of epigenetic modifications …
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Genetic Analysis of The Function of The Drosophila Doublesex-Related Factor Dmrt93B
DMRT (Doublesex and Mab-3 related transcription factor) proteins generally associated with sexual differentiation in many organisms share a common DNA binding domain and are often expressed in reproductive tissues. Aside from doublesex, which is a central factor in the regulation of sex …
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Quantitative Analysis Demonstrates Most Transcription Factors Require only Simple Models of Specificity
… cues. A key part of this process is transcriptional regulation, which is largely accomplished by a complex network of transcription factor proteins: TFs) interact with their specific binding sites in the genome. Understanding how TFs select correct binding sites out of the vast number …
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The Influence of a Single Nucleotide Polymorphism In The Matrix Metalloproteinase-1 Promoter on Glioma Biology
… nucleotide creates a binding site for ETS transcription factors and combined with the AP-1 binding site at position -1602 creates a Ras Responsive Element. We determined that the distribution of the MMP-1 genotype differed significantly between the healthy population and the glioblastoma …
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New quinazoline analogues as NF-κB activation inhibitors
<p>NF-κB is a transcription factor protein complex that plays an important role in some cancers and inflammatory responses. It can enhance the proliferation rate, reduce apoptosis, as well as create more blood flow to ensure the survival of cancer. Thus blocking the NF-κB pathway has potential …