Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Transcription factor binding sites (TFBS)"”.
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Genome-Wide Localization And Novel Deposition Pathways Of Histone Variant H3.3 In Embryonic Stem And Neuronal Precursor Cells
… ribosomal DNA (rDNA), and genic and intergenic transcription factor binding sites (TFBS). Transcriptional termination sites of highly transcribed genes are marked by peaks of H3.3 and phosphorylated RNA polymerase II. Differentiation of ES cells into neural precursor cells (NPCs) leads to …
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De Novo Transcription Factor Binding Site Discovery: A Machine Learning And Model Selection Approach
… simple models for the positional distribution of transcription factor binding sites (TFBS) to the problem of TFBS discovery. As alternate measures of positional specificity, log-likelihood ratios for the three models are calculated and treated as features to classify TFBSs as biologically relevant …
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Tracing the evolution of lineage-specific transcription factor binding sites in a birth-death framework
… evolution of lineage-specific traits. Although transcription factor binding events show substantial variation across species, most computational approaches to study regulatory elements focus primarily upon highly conserved sites, and rely heavily upon multiple sequence alignments. However, …
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Computational approaches for analyzing regulatory regions in the human genome
… in the human genome play a critical role in transcriptional regulation. Alterations of the CRE have long been considered as the driving force of the human evolution. Recent studies also suggest that somatic mutations within the CRE can act as driver factors in cancer. With the growth of the …