Global ETD Search
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Showing 1 to 2 of 2 for “"Transcription activator-like effectors (TALE)"”.
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Study and engineering of nucleic acid-binding repeat proteins
From DNA replication and repair to transcription and translation, all aspects of molecular biology are governed by interactions between proteins and nucleic acids. Some of the nucleic acid-binding proteins have evolved repetitive structures and a modular sequence recognition mode. In particular, …
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Single molecule investigation of transcription activator-like effector search dynamics
… and accessibility of gene engineering. Transcription activator-like effectors (TALEs) are one such class that form a powerful gene-editing platform when fused to nuclease domains, thereby yielding TALEN systems. Despite pervasive use of TALENs for editing crops, small animals, eukaryotic …