Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Transcription activator-like effector nucleases (TALEN)"”.
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Creation and characterization of mice with a mutation disrupting binding of a transcriptional repressor of insulin-like growth factor 2
Insulin-like growth factor-2 (IGF2) is a key regulator of myogenesis as it promotes differentiation of myoblasts during embryonic and fetal development. A single nucleotide polymorphism (SNP) identified in pigs in intron 3 of IGF2 disrupts a binding site for the transcriptional repressor ZBED6 …
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Single molecule investigation of transcription activator-like effector search dynamics
… into the clinic. Several classes of programmable nucleases allowing for precise and targeted genomic edits are central to the rising popularity, flexibility, and accessibility of gene engineering. Transcription activator-like effectors (TALEs) are one such class that form a powerful gene-editing …