Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Transcription Repression"”.
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PLASTICITY IN PROTEIN SEQUENCE-FUNCTION RELATIONSHIPS
… as both an essential metabolic enzyme and a transcription regulator. In its repressor function, binding to the vitamin biotin allosterically activates BirA dimerization and the resulting repression complex assembly on the biotin operator sequence. Although the allosteric regulation is …
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Regulation of Gene Transcription by Estrogen Receptor Alpha: The Role of Cis Elements and Trans -Acting Factors
… chromatin remodeling, histone deacetylation, and transcription repression as proteins associated with the DNA-bound ERalpha. We have demonstrated that RbAp46 and RbAp48 interact with ERalpha in vitro and in vivo, associate with ERalpha at endogenous estrogen-responsive genes, and alter expression …
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14-3-3Sigma Negatively Regulates The Stability and Subcellular Localization of Cop1
… p53 degradation, p53 ubiquitination, and p53 transcription repression. COP1 expression promoted cell proliferation, cell transformation, and tumor progression, attesting to its role in cancer promotion. 14-3-3σ negatively regulated COP1 function and prevented tumor growth in cancer xenografts. …
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ROLES OF ACCESSORY DOMAINS IN THE CATALYTIC SUBUNIT OF ISW2
… cerevisiae and has been shown to be involved in transcription repression and DNA replication. The catalytic subunit of ISW2 consists of the ATPase domain and three domains at the C-terminus called HAND, SANT and SLIDE (HSS) domains. The individual roles of each HSS domains and how they coordinate …
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Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
… CDYL1, CSB and G9a proteins, all constituents of transcription repression complexes. Also preference of Arg at –1 position and a smaller amino acid at –2 position was identified. The results obtained are consistent with lax substrate specificities observed for the iron (II), 2- …
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AN EXAMINATION OF THE DOMAIN ARCHITECTURE OF THE IOC2 AND IOC3 SUBUNITS OF THE ISW1 COMPLEXES IN SACCHAROMYCES CEREVISIAE
… at the promoter region of genes, functioning in transcription repression. True to this function, it exhibits directional remodeling activity and the ability to space nucleosome arrays at ~175bp increments, promoting the formation of a repressive chromatin structure. ISW1b lacks both of these …
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Investigating the role of sufT in Mycobacterium abscessus using CRISPRi
… (CRISPRi) system was recently optimized for transcription repression in mycobacteria. This study aimed to investigate the functionality of the mycobacterial CRISPRi in M. abscessus, specifically to investigate the role of the sufT homologue, MAB_2744c, in survival under iron limiting …
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Characterising the interaction between TRIM28 and members of the Krab-ZFP family in transcription silencing
… embryogenesis, largely through TRIM28-mediated transcription repression. TRIM28 (also known as KAP1 or TIF1β) functions as the co-repressor protein for the largest family of transcription factors, namely the Krüppel-associated box-containing zinc finger proteins (Krab-ZFPs). Silencing is …
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Using "Designer" Nucleosomes to Study Enzymatic Crosstalk Between Histone Ubiquitylation and Histone Methyltransferases
… that H3 lysine 4 methyltransferases involved in transcriptional activation are stimulated and repressed by H2Bub and H2Aub, respectively. Here, using chemically-defined "designer" mononucleosomes, I tested whether nucleosomal H2BK120ub and H2AK119ub influence the activity of a well-studied …
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Regulatory of genome maintenance
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-12-01
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Regulation of fatty acid synthesis in enterococcus faecalis
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms