Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Transcription Inhibition"”.
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MicroRNA Expression Signature of Retinal Pigmented Epithelial Cells Associated with the Phenotype of Age-Related Macular Degeneration
… are responsible for gene silencing on the post-transcriptional level via the degradation or transcription inhibition of specific mRNA transcripts. In the context of age-related macular degeneration, certain miRNAs may be upregulated to induce the downregulation of apoptotic genes. On the other …
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New methodologies for studying the biological activity of platinum complexes
… for biological activity in human cancer cells, a transcription inhibition assay was developed. A stable HeLa cell line was generated with doxycycline-inducible enhanced green fluorescent protein (EGFP). The effect of platinum complexes and other cytotoxic agents on EGFP expression was assessed. …
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Super-resolution Imaging of Chromatin and Functional Nuclear Architecture
The regulation of transcription is well understood to be linked to the three-dimensional organisation of the genome within the nucleus, however, the mechanisms through which the different levels of organisation regulate genes are poorly understood. Newly developing super-resolution imaging …
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Genomic and microscopic dissection of nuclear compartmentalization and function
… could be partitioned into two compartments: transcriptionally active and inactive chromatin positioned at the interior and periphery of the nucleus, respectively. Newer genomic methods (SPRITE, GAM) suggest multi-way interactions occurring more frequently in the nuclear interior, specifically …
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Understanding the relationship between large-scale chromatin structure and gene expression
… of active genomic regions is weighted towards transcription factors, co-activating proteins, and active histone modifications such as acetylation. Active regions are associated with more disrupted chromatin fibre structure, greater chromatin accessibility and cytological decompaction of …
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Development of small molecules toward therapeutic applications for myotonic dystrophy and cancer
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01