Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Transcription Factor Protein"”.
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New quinazoline analogues as NF-κB activation inhibitors
<p>NF-κB is a transcription factor protein complex that plays an important role in some cancers and inflammatory responses. It can enhance the proliferation rate, reduce apoptosis, as well as create more blood flow to ensure the survival of cancer. Thus blocking the NF-κB pathway has potential …
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Testing metabolic and pharmacological agents for recovery following de novo acute heart failure in an isolated rat heart model
… of high density lipoprotein) for recovery. In isolated rat hearts, the protocol consisted of three phases: stabilization at normotensive perfusion pressure, hypotensive acute heart failure and recovery by restoring normotension. Low glucose (2.5mM) and high …
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Deciphering the Functional Collaboration of Mid and bric-a-brac 2 as Potential Regulators of Cellular Proliferation Within Adult <i>Drosophila</i> Ovaries
… et al. [2] reported that Gurken/Epidermal Growth Factor Receptor (EGFR) signaling is modulated within posterior ovarian follicle cells by Midline (Mid). The <em>mid</em> gene encodes a T-box transcription factor protein that specifies cell fates in the developing heart [3][4], central nervous …
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Alignment, Clustering and Extraction of Structured Motifs in DNA Promoter Sequences
… and believed to act as a binding site for a transcription factor protein. A structured motif is a sequence of simple motifs (boxes) separated by short sequences (gaps). Biologists theorize that the presence of these motifs play a key role in gene expression regulation. Discovering these …
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Differences of DNA-Transcription Factor Interactions Following Chromium Exposure
… observed to change the binding affinity of the transcription factor for the êB DNA sequences at each modified guanine site. The protocol used a p50 binding domain protein (residues 23 to 366 from the p50 protein) and a p50 mutant protein with a single amino acid mutation of the wild type …
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Differences of DNA-Transcription Factor Interactions Following Chromium Exposure
… observed to change the binding affinity of the transcription factor for the êB DNA sequences at each modified guanine site. The protocol used a p50 binding domain protein (residues 23 to 366 from the p50 protein) and a p50 mutant protein with a single amino acid mutation of the wild type …
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Comparative Analysis of Alternative Splicing in Homo sapiens, Mus musculus and Rattus norvegicus Transcriptomes
… produces structurally and functionally different proteins. Regulation of alternative splicing could be tissue-specific, developmental stage and/or physiological condition dependent. Comprehensive analysis of alternative splicing is essential to understand fully the capacity of genomes and thus …
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Identification and Characterisation of Human Cytomegalovirus-Mediated Degradation of Helicase-Like Transcription Factor
Viruses are known to degrade host factors that are important in innate antiviral immunity in order to infect successfully. To systematically identify host proteins targeted for early degradation by human cytomegalovirus (HCMV), the lab developed orthogonal screens using high resolution multiplexed …
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STRUCTURAL ANALYSES OF TRANSCRIPTION FACTOR/DNA COMPLEXES: NFI-X AND NF-Y
Binding of transcription factors (TFs) to discrete sequences in gene promoters and enhancers is crucial to the process by which genetic information is transferred to biological functions. TF structural analysis is the key to understanding their DNA-binding mode and for the design of specific …
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Charakterisierung eines neuen Proteins, Mapl-1 und seine Rolle in der Regulation der Pax-6 Funktion.
Die Pax-Proteine stellen eine Familie von stark konservierten Transkriptionsfaktoren dar die, während der embryonalen Entwicklung und Organogenese eine Schlüsselrolle spielen. Das gemeinsame Strukturmotiv dieser Genfamilie ist die Paired-Box, die zuerst in der Fruchtfliege Drosophila melanogaster …