Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Transcription Factor AP-1"”.
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Inhibition of the transcription factor AP-1 in cervical cancer
AP-I is a dimeric transcription factor comprised primarily of Jun and Fos family proteins, that regulates numerous genes involved in cell proliferation, differentiation and oncogenesis. The expression of AP-I is shown to play an important role in many human cancers and plays a key role in the …
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Ενεργοποίηση του ογκογονιδίου ha-ras1 του ανθρώπου από ογκογονίδια ιών και κυττάρων
… RAS ONCOGENE FAMILY. RAS GENES ARE ACTIVATED IN APPROXIMATELY 50% OF HUMAN TUMOURS. THEREFORE, THE UNDERSTANDING OF THEMECHANISMS OF THEIR ACTIVATION IS CONSIDERED TO BE VERY IMPORTANT FOR THE PROGNOSIS, DIAGNOSIS AND THERAPY OF CANCER. THIS THESIS DESCRIBES STUDIES ON THE REGULATION OF THE HUMAN …
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Role and Regulation of Epha2 In Pancreatic Cancer
… in the US. Gemcitabine is the first-line therapy for this disease, but unfortunately it shows only very modest benefit. The focus of the current study was to investigate the role and regulation of EphA2, a receptor tyrosine kinase expressed in PDAC, to further understand this disease and …
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Functional Characterization of the HIV-1 NEF Acidic Cluster
… Report). Unfortunately, various socioeconomic factors have hastened the epidemic spread of HIV in Africa and in third world countries where many individuals do not have access to appropriate healthcare. Vaccines have, as of yet, been unsuccessful as a preventive measure; however, new measures, …
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PI(4)P-Dependent Recruitment of Clathrin Adaptors to the Trans-Golgi Network
… are organized by many types of trafficking adaptors. These include the heterotetrameric adaptor protein complexes (APs) and the monomeric Golgi-localized, gamma-ear containing, Arf-binding proteins (GGAs). The fundamental question of how these adaptors are recruited to TGN membrane remains …
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ADAP1 Promotes Latent HIV-1 Reactivation by Tuning the KRAS-ERK-AP-1 Signaling-Transcriptional Axis
Immune stimulation fuels cell signaling-transcriptional programs that induce biological responses to eliminate virus-infected cells. Yet, retroviruses that integrate into host cell chromatin, such as HIV-1, co-opt these programs to switch between latent and reactivated states. However, many …
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Retinoic Acid Regulation of Thyroid Hormone Action in Bone Cells
… that the effect of retinoic acid treatment appears to be complex involving both stimulation and inhibition of differentiation depending on dose as well as differentiation status of cells.</p>