Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Transcription, Genetic"”.
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Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… migration or survival. However, the transcription factors and signaling molecules that specify unique subsets of neural crest cells are still being detailed. This thesis represents efforts to understand those particulars. Endothelin-1 (Et-1), a small signaling peptide, is important …
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Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… migration or survival. However, the transcription factors and signaling molecules that specify unique subsets of neural crest cells are still being detailed. This thesis represents efforts to understand those particulars. Endothelin-1 (Et-1), a small signaling peptide, is important …
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Transcription in Escherichia coli growing rapidly or slowly
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Roles of Class II Histone Deacetylases in the Cardiovascular System
… of the fundamental mechanisms to control gene transcription. Class II histone deacetylases regulate developmental and physiological processes through interaction with and repression of a variety of transcription factors, including myocyte enhancer factor 2 (MEF2). Using gene targeting combined …
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The Analysis of the MCF7 Cancer Model System and the Effects of 5-AZA-2'-Deoxycytidine Treatment on the Chromantin State Using a Novel Microarray-Based Technology for High Resolution Global Chromatin State Measurement
… cell line was determined and correlated with transcriptional activity. The chromatin array showed a significant portion (>3,000) of the genes were in a condensation state that was neither condensed or relaxed as a result of heterogeneity in the condensation states in the population. The …
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Transcriptional regulation of the mouse mu opioid receptor gene
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Metabolic Regulation of Transcription Through Compartmentalized NAD+ Biosynthesis
… emerging concept of metabolic regulation of transcription reveals that fluctuation of metabolite levels could modulate the activities of enzymes involved in gene regulation, which require substrates or cofactors that are intermediates of cell metabolism. However, how cells integrate …
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β-Globin Enhancers Regulate Bistable Gene Expression States
… of target gene expression in the cell, and genetic deletion will cause single-cell expression phenotypes. However, this model has been challenging to test in human cells. To examine the role of the human β-globin enhancers in controlling single-cell expression phenotypes, we engineered a …
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The Role of TNRC6 in RNA Interference
Small RNAs can influence translation, splicing, transcriptional activation, and transcriptional repression, through the RNA interference (RNAi) pathway. TNRC6, also known as GW182, and Argonaute (AGO) are the core proteins of RNAi. TNRC6 is a scaffolding protein that associates with AGO and bridges …
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HP1BP3, A Chromatin Retention Factor for Co-Transcriptional MicroRNA Processing
RNA interference (RNAi) is a post-transcriptional gene silencing mechanism found in all eukaryotic organisms. It is characterized by a family of small non-coding RNAs, either endogenous (in the case of microRNAs) or exogenous (in the case of siRNAs), that inhibits gene expression …
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Regulation of Transcription Through RNA Polymerase II Promoter-Proximal Pausing
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Molecular Regulation of Direct Cardiac Reprogramming
… (iCMs) by forced expression of cardiac specific transcription factors holds promise for enhancing cardiac repair by reducing scar tissue while simultaneously generating new cardiomyocytes. However, low efficiency as well as a lack of understanding of molecular mechanism of the reprogramming …
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Intracellular Traits of Chimeric tRNAlys3-ribozymes and their Inhibition of HIV
… primer recruited by HIV-1 for initiating reverse transcription. When ribozymes targeted upstream of the primer binding site of the HIV-1 genome are tethered to the 3' end of the tRNALYs3, it is expected that the tRNA will carry the ribozymes into the virions. We made constructs that express …
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Transcriptional Mechanisms Underlying Neuronal Activity-Dependent Plasticity
Pages 1-110 are misnumbered as pages 2-111.
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Type I Interferon Mediates Th2 Reprogramming and Acute Suppression of Effector Functions
… well as memory Th2 cell function. The Th2 master transcription factor GATA3, promotes its own expression through a positive regulatory loop, uncoupling the cell from the requirement of IL-4 signaling. IFN-α/β inhibits this process by inducing epigenetic modifications within the GATA3 locus that …