Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Transcript variant"”.
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Characterization and Functional Analysis of a Newly Identified Human MT5-MMP Transcript Variant Isolated from Multipotent NT2 Cells
… and was characterized by a 162 bp deletion. Both transcripts could be identified in NT2, hNT and adult human hippocampus. The newly cloned MT5-MMPvar cDNA translated into an approximately 52 kDa protein as seen in in vitro expression studies. Using an MTS-MMPvar specific antibody designed to span …
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Identification and validation of new therapeutic targets for squamous cell lung cancer
… for LUSC. The lineage- survival oncogene and transcription factor SOX2 is dysregulated by gene amplification in a large proportion of LUSC tumours and has been implicated as a key driver in multiple preclinical functional studies. As a transcription factor, SOX2 itself makes a challenging drug …
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Investigating upstream regulators of FOXA1 in breast cancer
FOXA1 is a lineage-defining transcription factor called pioneer factor. Due to its role in recruitment of nuclear receptors, such as estrogen receptor α (ERα) to enhancer regions, it is highly implicated in ERα positive breast cancer. Structural predictions of FOXA1 suggest a highly disordered …
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ACID-SENSING ION CHANNELS: TARGETS FOR NEUROPEPTIDE MODULATION AND NEURONAL DAMAGE
… I cloned and characterized a novel human ASIC1 transcript variant (human ASIC1b). I discovered that this variant forms functional channels and is expressed in dorsal root ganglia. Furthermore, I discovered that, unlike its rodent homolog, human ASIC1b displays a non-inactivating sustained …
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Alternative splicing of the zebrafish myosin phosphatase targeting subunit, MYPT1, produces a novel isoform
<p>Alternative splicing of the zebrafish Myosin Phosphatase Targeting Subunit, MYPT1, produces a novel isoform (TV202). TV202 and the truncated TV202Δ ere shown to form an active complex with Protein Phosphatase 1 β (PP1β) via stress fiber assay. TV202 was also shown to be localized in the …
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Microarray and molecular genetic analysis of aberrant splicing in human drug metabolizing cytochromes P450 CYP2D6 and CYP2B6
… 2D6 and 2B6, mapping of the most common splice variants and to draw connections to certain single nucleotide polymorphisms (SNPs) and alleles. For both enzymes a splicing sensitive microarray was developed. The microarray was produced and optimized in all steps including the oligonucleotide …