Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1021 for “"Transcript"”.
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Transcript Regulation within the Kcnq1 Domain
… of methylation. Methylation marks can influence transcript expression, resulting in only one allele being expressed. One imprinted domain is the Kcnq1 domain located on chromosome 11p15.5 in humans and chromosome 7 in the mouse. This domain is thought to be under the control of a paternally …
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Transcript Diversity In The Protozoan Parasite Toxoplasma Gondii
… advances have made possible to sequence RNA transcripts at unprecedented depth, enabling deep profiling of abundance and diversity under a variety of conditions. Such information permits refinement of draft genome annotation originally generated in the absence of transcript coverage data, and …
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Statistical methods in a high school transcript survey
<p>In complex surveys that involve stratification and clustering structures, given the budget, time and resource restrictions, the surveys are usually designed to produce specific accuracy of direct estimation at high levels of aggregation. Sample sizes for small geographical areas or …
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Strainer: State Transcript Rating for Informed News Entity Retrieval
<p>Over the past two decades there has been a rapid decline in public oversight of state and local governments. From 2003 to 2014, the number of journalists assigned to cover the proceedings in state houses has declined by more than 30\%. During the same time period, non-profit projects such as …
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Transcript leaders : annotation and insight into functions in translation
… undergoes a series of several steps, including transcription, modification, splicing, packaging, export, localization, translation, and decay. Of these steps transcription is the most extensively studied, though the remaining steps are also indispensible for proper protein production. While we …
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Transcript Profiling of Soybean Seed Development From Fertilization to Maturity
… stages of development, while genes involved in transcription were often over-expressed at the later, desiccating stages of development. This may indicate the transcripts or products of these genes are stored in the quiescent seeds for use in early stages of imbibition and germination.
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Genetic architecture of transcript splicing in blood and phenotypic consequences
Transcript splicing is a fundamental process which allows for the generation of multiple different isoforms from a single gene body, increasing the functional capacity of our genomes. Bulk RNA-sequencing has allowed us to analyse this at scale by investigating not only the amount of a gene product …
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Bayesian Modeling for Isoform Identification and Phenotype-specific Transcript Assembly
… biological processes at the genomic level, transcriptomic level, and proteomic level. Due to the large noise in the data and the high complexity of diseases (such as cancer), it is a challenging task for researchers to extract biologically meaningful information that can help reveal the …
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Regulating transcript fate through RNA elements in the 3' untranslated region
… of such endeavors has been on the regulation of transcription, but increasingly there has been a concentration on the post-transcriptional regulation of mRNAs via miRNAs, other small RNAs, and RNA binding proteins. Controlled translation of transcripts has been shown to play a vital role in rapid …
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Cocaine- and Amphetamine-Regulated Transcript Peptide Attenuates Baroreflex in the Rat.
<p>Cocaine- and amphetamine-regulated transcript (CART) was first identified in the rat striatum where levels were upregulated following cocaine or amphetamine administration. A dense plexus of CART-immunoreactive fibers is noted in the nucleus of the solitary tract (NTS). Results from …
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Coevolution of plastid genomes and transcript processing pathways in photosynthetic alveolates
… plasmid-like elements termed “minicircles”. Transcripts of this genome receive a 3’ poly(U) tail and, in some species, undergo extensive sequence editing. Some dinoflagellates have replaced their original plastids with others, in a process termed “serial endosymbiosis”. The major …
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A Novel NGS Assay to Detect Any KMT2A Fusion Transcript at Low Levels
… any known exon junction of cDNA corresponding to transcripts of the gene of interest, while non-extensible oligonucleotides (blockers) span the wildtype (WT) exon junction, therefore suppressing amplification of WT while differentially amplifying fusion junctions. We tested this assay in cell …
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Identification of substrate-selective histone deacetylases and their inhibitors that mediate HER2 transcript stability
… can induce the rapid decay of oncogenic transcripts such as the HER2 mRNA, though the mechanism underlying this process remains undefined. Earlier observations in our lab led to speculation that protein(s) binding the 3’-untranslated region (UTR) of HER2 mRNA become acetylated following …
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The Effects of Participation in a Student Development Mentoring-Transcript Program on Freshmen University Students
… participation in a Student Development Mentoring-Transcript Program on freshmen University students, (b) to ascertain the perceived value of participation in such a program for University students, (c) to develop recommendations regarding the implementation of mentoring-transcript programs at …
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DNA methylation analysis and identification of a novel antisense transcript in the Peg3 imprinted domain
… region for both CpG islands and long antisense transcripts, two common features of imprinted gene clusters. First, we performed a systematic survey of DNA methylation status of the CpG islands in this region of the mouse, cow, and human genomes. We identified two previously unreported …
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Analysis of the regulation of GIGANTEA transcript and protein accumulation in Arabidopsis and recombinant expression
… During the day, circadian clock control of GI transcription together with post-translational control of GI protein levels results in accumulation of GI, which is then degraded in the dark. Despite recent discoveries of GI interactors that might explain how GI influences some of the processes it …
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Ovarian and Growth Hormone Regulation of Mammary Growth and Transcript Abundance in Prepubertal Dairy Heifers
… of mammary growth and development as well as transcript abundance in early prepubertal bovine mammary gland by ovarian secretions and exogenous bovine somatotropin (bST). In the first study, we determined the effect of staged ovariectomy on mammary growth and development in two to four month …
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The general education component of the curriculum through transcript analysis at three Virginia community colleges
Using transcript analysis as a research methodology, this study investigated student course-taking patterns in general education at three community colleges in Virginia. The sample included three groups: completers and non-completers of associate degree programs and non-curricular students. A panel …
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