Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Transcorneal permeability"”.
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Preformulation Characterization And Formulation Development of Δ9-Tetrahydrocannabinol Prodrugs For Potential Treatment Of Glacuoma
… model to screen the various formulations for transcorneal permeability was also developed. Promising formulations were instilled in vivo in anesthetized rabbit model and tissue concentrations were determined. Earlier formulations reported in the literature, used for determining efficacy were …
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Lipid Based Frameworks And Topical Ocular Inserts For The Delivery Of Small Molecule Therapeutics To The Posterior Segment Of The Eye
… using Ciprofloxacin (CIP) as a model drug. Transcorneal penetration of CIP from NLCs was optimum with PEG molecular weight in between 2K to 10K. In vivo ocular tissue CIP concentrations attained from the various formulations was consistent with the in vitro data obtained. Feasibility of …
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Biopharmaceutical approaches for improved drug delivery across ocular barriers
… delivery of P-gp substrates. </p> <p>In vitro transcorneal permeation results demonstrated that chitosan brought about a dose dependent increase in the permeability of acyclovir, a model hydrophilic compound. Combination of chitosan, BAK and EDTA resulted in a synergistic effect on the …
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Development of Multiple Microemulsion Eye Drops for Sustained Release of New Glaucoma Drug
<p>Persistent or repeated elevation of intraocular pressure (IOP) is a primary risk factor of visual field loss in glaucoma, therefore IOP reduction is the first-line therapeutic option in the disease management. Unfortunately, the current therapies are associated with a lot of deficiencies …