Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Transcellular"”.
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ROLE OF ACID SPHINGOMYELINASE IN ICAM-1/NHE1-DEPENDENT ENDOCYTOSIS: IMPLICATIONS IN LEUKOCYTE TRANSMIGRATION
… (TEM) of leukocytes, particularly via the transcellular route. This involves endothelial endocytic vesicles that coalesce into transmigration pores, through which leukocytes transmigrate without disrupting EC junctions. The contribution of CAM-mediated endocytosis to the formation of …
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Mechanotransduction via airway epithelial cells : the effect of compressive stress
… during bronchoconstriction. The application of a transcellular pressure gradient (10-50cmH20) for 10 minutes resulted in transient activation of the epidermal growth factor receptor (EGFR) - MAP kinase (ERK) signaling pathway. Furthermore, specialized real-time high-speed imaging revealed an …
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The development of preclinical strategies for facilitation of lead candidate selection
… a diffusive barrier to both paracellular and transcellular movement of many compounds in and out of the brain. The main rate- limiting barriers of the BBB include exclusive tight junctions that prevent the movement of hydrophilic molecules through intercellular gaps, and efflux proteins in the …
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Analysis of a model to describe lead transport by the small intestine
… absorption, probably by the utilisation of a transcellular transport route. The studies indicate why, under normal conditions, only a small percentage of lead is absorbed, and also suggest the manner by which larger arrounts of lead may gain entry into the body.
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Modulation of drug transport by citrus fruit juices
… solute transport data for the paracellular and transcellular diffusive pathways and on P-gp-mediated efflux activity across the Caco-2 cells supported the hypothesis. Bi-directional digoxin transport data across the MDR1-transfected L-MDR1 cells also produced a similar conclusion. The hypothesis …
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The development of a novel in vitro model suitable for the prediction of bioavailability
… with selectivity between paracellular and transcellular markers and hydrophilic and lipophilic compounds within an homologous series of beta-blockers.
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Brain microvascular endothelial cell dysfunction in schizophrenia: a preliminary report
… endothelial cells (BMECs) have paracellular and transcellular proteins, transporters, as well as important extracellular matrix proteins, which collectively contribute to maintaining proper BBB function. While previous studies have provided some insights into the role of the BBB in SZ …
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Investigation of the absorption pathways of some poorly absorbed drugs using human intestinal (CAC0-2) cell monolayers
… epithelium is via two pathways; the transcellular and paracellular pathway. Caco-2 cells, when cultured on polycarbonate filters, formed a confluent monolayer with many properties of differentiated intestinal epithelial cells, As a model of human gastro-intestinaJ tract epithelia they …
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Thermotherapeutic enhancement of infusate distribution during convection enhanced delivery in the brain using fiber-optic microneedle devices
… interstitial fluid pressure and increasing transcellular fluid transport. These results were validated in a companion in vivo FMD-CED study in the rodent brain.
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Ryanodine receptor expression in trophoblasts
… regulating various cellular activities. Transcellular Ca2+ transport through trophoblasts is essential in fetal skeleton formation. Ryanodine receptors (RyRs) are high conductance cation channels that mediate Ca2+ release from intracellular stores to the cytoplasm. To date, the roles of …
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Effects of Febuxostat on Autistic Behaviors and Computational Investigations of Diffusion and Pharmacokinetics
… cells of the blood-brain barrier (BBB) by the transcellular pathway. In the second study, male juvenile autistic (BTBR) mice were treated with febuxostat for seven days followed by behavioral testing and quantification of oxidative stress in brain tissue compared to controls. Results of the …
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A Transmembrane Precursor of Secretory Component
… and is thought to be the receptor mediating the transcellular transport of pIg. We studied the biosynthesis and processing of rabbit and human SC. Using translation of mRNA from rabbit mammary gland and liver in a cell-free system supplemented with dog pancreas microsomal vesicles, we discovered …
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IN VITRO LUNG EPITHELIAL CELL TRANSPORT AND ANTI-INFLAMMATORY ACTIVITY FOR LIPOSOMAL CIPROFLOXACIN
… which suggested predominant transcellular transport. Compared to CPFX, Lipo-CPFX showed 6-18 times slower transport, while the flux was increased with increasing concentration proportionally without saturation. Its unaltered transport by cellular energy depletion, transport …
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Mechanism(s) involved in the transport of Fenretinide across Caco-2 monolayers
… Resistance (TEER) and antipyrine permeability (transcellular marker) were not affected after treatment with 0.5% PVP K 25 on the apical side. The apparent permeability coefficient (P<sub>app</sub>) of fenreti nide was extremely low [(8.8 ± 0.5) x 10<sup>-8</sup> cm/sec] even in the presence of …
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Novel Transporter Targeted Lipid Ester Prodrugs of Cidofovir and Sustained Release Formulations for Cytomegalovirus Infection
… log p (-3.9) of CDF are unfavorable for passive transcellular absorption. Therefore, we have tested novel transporter targeted lipid prodrugs of CDF and their nanoparticle formulations to achieve sustain drug delivery for the treatment of CMV retinitis. These prodrugs contains lipid linker of …
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Ocular pharmacokinetics and efficacy of various amino acid and dipeptide prodrugs of ganciclovir
… be due to the absorption of these drugs via both transcellular passive diffusion and hPEPT1 mediated transport across corneal epithelium. L-Tyrosine-L-Valine-GCV was also found to have excellent antiviral activity in comparison with currently available product, TFT.
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Computational Modelling of Fluid and Ion Transport in the Epithelial Cell
… it was found that the cell was absorptive, where transcellular sodium flux dominated; chloride flux was 200 times smaller. It was found that blocking the cystic fibrosis transmembrane regulator had limited impact at baseline, but was the key to the transport of fluid in both normal and edematous …
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Imaging studies of glycan mediated breast cancer epithelial cell-endothelial cell interactions
… by endothelial retraction. In addition to this, transcellular migration was also imaged using scanning electron microscopy.
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Regulation of sodium channel densities in A6 renal epithelial cells by hormonally-dependent mechanisms
… constitute the rate limiting step in the transcellular transport of sodium. The regulation of sodium ion reabsorption in the kidney, which is essential for salt and water homeostasis, is therefore governed by the cellular control of ENaC activity. It is well established that the …
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Transport of Antibodies and Nanoparticles across An in vitro Blood-Brain Barrier
… in Yuan et al (2010), we developed a new transcellular transport model, which incorporates the charge at the surface glycocalyx of the bEnd3 monolayer, the mechanical property of the cell membrane, the ion concentrations of the surrounding salt solution, the size and charge of the NPs. Our …
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