Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Trajectory Inference"”.
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Riemannian Metric Learning via Optimal Transport
… learned using our method improve the quality of trajectory inference on scRNA and bird migration data at the cost of little additional cross-sectional data.
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Μεταγραφωματική και επιγενετική ανάλυση μονήρων κυττάρων ασθενών με καρκίνο του πνεύμονα
… της επίδρασης του καπνίσματος, ενώ ανάλυση trajectory inference χρησιμοποιήθηκε για τη μελέτη των μονοπατιών διαφοροποίησης των επιθηλιακών κυττάρων. Τα αποτελέσματα ανέδειξαν διακριτούς κυτταρικούς πληθυσμούς με χαρακτηριστικά μοτίβα γονιδιακής έκφρασης και προσβασιμότητας της χρωματίνης. …
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Fundamental representations of regions and interactions in spatial transcriptomics
… analysis workflows, such as clustering and trajectory inference, to be applied in spatial contexts. However, we find that naive smoothing introduces artifacts that obscure meaningful spatial features. To address this, we introduce a minimal but powerful modification: subsampling within each …
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Neural algorithmic reasoning in a bottle(neck)
… the utility of algorithmic reasoning in trajectory inference, the task of understanding how cells evolve during their lifetime. A neural model optimised to be a probabilistic proxy of the algorithm that often underlies existing approaches is integrated into a trajectory inference …
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Smooth Interpolation on Series of Measures
… between series of measures with a focus on trajectory inference. In many application scenarios, we seek to model continuous phenomena with sequences of discrete data. This task is particularly important when working with time-series data, where we have access to snapshots of a process at …
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Understanding Development of Human Immunity One Cell at a Time
… to leverage scVDJ-seq data in pseudotime trajectory inference. The application of Dandelion improved the alignment of human thymic development trajectories of double positive T cells to mature single-positive CD4/CD8 T cells, and provided novel insights into the origins of human B1 cells …
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Deciphering Leukaemogenic Mechanisms through System-Scale Analysis of Single-Cell RNA Sequencing Data
… upon current computational methods for cellular trajectory inference from single-cell data. Whilst high-throughput experiments allow for the sequencing of large cell numbers, this is balanced by the sparse and noisy nature of the returned data. Current methods perform poorly on such datasets and …
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3D Human Skeletal Muscle Model for Studying Satellite Cell Quiescence and Pompe disease
… markers. Furthermore, we performed trajectory inference along the deactivation process from 2D myoblasts to qSCs and identified deactivation-associated genes, included downregulated genes for proliferation, cytoskeletal reorganization, and myogenic differentiation. In response to …
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A systems biology approach to the pathogenesis and progression of Non-Alcoholic Fatty Liver Disease
… method that successfully captures the disease trajectory in a continuum. Based on the pathway enrichment and upstream regulator analysis results, I show that my analysis matches the results of the discrete approach supervised by histology, providing additional granularity and better defining …