Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Trabecular meshwork"”.
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Selenium Effects on the Trabecular Meshwork
… the effects of selenium on the conventional "trabecular" aqueous outflow pathway, a likely site of pathology for glaucoma. Human trabecular meshwork (HTM) cells and human umbilical vein endothelial cells (HUVECs) were treated with selenium (MSeA) at or near physiologically relevant …
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Phenotypic Characterization of Segmental Human Trabecular Meshwork Cells
… Aqueous humor outflow is segmental in the trabecular meshwork (TM) with regions of high-flow (HF) or low-flow (LF) that vary in molecular signature, biomechanics, and response to pressure in both normal and glaucoma eyes. We sought to investigate whether cells in these regions (1) deposit …
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The Relationship of Trabecular Meshwork Stiffness and Outflow Function
<p>The trabecular meshwork (TM) is comparable to a bioactive filter that plays a major role in regulating outflow of aqueous humor of the eye and setting intraocular pressure (IOP). TM dysfunction may lead to ocular hypertension which is the major risk factor in glaucoma. Although the outflow …
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Uniaxially aligned, porous collagen-GAG scaffolds for in vitro modeling of trabecular meshwork
… outflow of aqueous humor through the trabecular meshwork (TM). The trabecular meshwork is a complex, three dimensional tissue in the eye composed of organized layers of TM cells in an extracellular matrix consisting primarily of collagen and glycosaminoglycan (GAG). Many groups have …
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Determining Mechanisms by which Pathological Extracellular Matrix induces Ocular Hypertensive Phenotypes in Human Trabecular Meshwork Cells
… in several sight-threatening diseases; in the trabecular meshwork (TM), it is implicated in elevated intraocular pressure (IOP), the only treatable risk factor for glaucoma. Herein, two different glaucoma-relevant cell-derived matrices (CDMs) were used to dissect the specific mechanisms by …
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Magnetic Steering to Save Sight: Trabecular Meshwork Cell Therapy as a Treatment for Primary Open Angle Glaucoma
… IOP, but they often have low success rates. The trabecular meshwork (TM) is a key regulator of IOP and has been shown to undergo significant changes in POAG including a loss of cells. This motivates the regeneration or restoration of the TM as a potential treatment for POAG. While TM cell therapy …
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Identification of Actin Binding Proteins Associated with Cross-Linked Actin Networks
… with cross-linked actin network (CLANs). Human trabecular meshwork ™ cells were cultured to confluence and treated with dexamethasone or vehicle for 14 days. Total RNA was extracted for gene expression analysis to confirm steroid-induced expression of actin binding proteins in human TM cells. …
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Development of Multiple Microemulsion Eye Drops for Sustained Release of New Glaucoma Drug
… CACNA2D1 in eye tissues (ciliary body and trabecular meshwork) to lower IOP in a dose-dependent manner. The research presented in this dissertation aimed to develop a once-daily ocular pregabalin-loaded multiple water-in-oil-in-water microemulsion eye drops. Several in vitro and in vivo …
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Tissue-engineered in vitro models for studying lymphatic morphogenesis, pathogenesis, and drug delivery
… aqueous humor outflow model that incorporates trabecular meshwork and Schlemm’s canal, and TGF-β1/ALK5/VEGFC signaling axis in steroid-induced glaucoma. Then, I discuss the double-casting sacrificial 3D printing method to study lymphatic valve morphogenesis and inflammation-induced lymphatic …
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Drug delivery strategies to overcome ocular hypertension
… IDNPs was tested in a fibrotic model with human trabecular meshwork cells, where they effectively reduced connective tissue growth factor expression—a marker of fibrosis. These strategies provide enhanced drug delivery through prolonged release or co-delivery, offering promising alternatives for …
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Hydrogen Sulfide in Glaucoma: Delivery System, Hypotensive and Neuroprotective Effects
… H2S acts as a smooth muscle relaxant, decreases trabecular meshwork volume, and decreases the IOP. It also scavenges reactive oxygen species, upregulates glutathione, and controls sympathetic neurotransmission to offer neuroprotection. Although H2S has potential as a treatment strategy for …
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Ontogenesis of the cornea and ciliary body : a morphological and molecular study
… the cornea, lens, iris, ciliary body and trabecular meshwork, with each of these elements playing a vital role in the maintenance of vision. The primary objective of this research is to contribute towards the understanding of how specific genes control tissue specification and structural …
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Bioenergetic neuroprotection in experimental glaucoma
… unilaterally by laser photocoagulation of the trabecular meshwork and episcleral veins, in control and pyruvate-supplemented rats. At two weeks, the retina and optic nerves were processed for quantification of the number of surviving RGCs and axonal injury, respectively. The combined results …
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Implications of dopamine D3 receptor for glaucoma: in-silico and in-vivo studies
… is eventually followed by laser surgery of the trabecular meshwork (TM) and glaucoma-filtering surgery. Currently, there are five main classes of approved ocular hypotensive drugs: beta-blockers, carbonic anhydrase inhibitors, prostaglandin analogs, sympathomimetics and miotics. However, there …
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Effect of Hydrogen Sulfide Donors on Sympathetic Neurotransmission and Intraocular Pressure of the Eye
… iris muscles that increases space between the trabecular meshwork. This improves drainage of aqueous humor which can help alleviate IOP.|In this study, the effect of two H2S donors, GYY 4137 and ACS67 and L-cysteine, the substrate for endogenous H2S production on electrically evoked [3H]NE …
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Structural and functional investigation of the trabecular outflow pathway
… of studies which investigated structures of the trabecular outflow pathway, including Schlemm’s canal endothelium, juxtacanalicular tissue, and trabecular beams, and their roles in regulating aqueous outflow resistance. The studies were conducted in both human and animal models using ex vivo …
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Long Term Ocular Drug Delivery with Novel Pentablock Copolymers; Part I: Composite Nanoformulation of Macromolecules For Back of the Eye Diseases, Part II: Dexamethasone Nanoparticle to Develop an In Vitro Model for Glaucoma
… different strains of primary cultures of human trabecular meshwork (HTM) cell line (HTM120, 136, 126, 134 and 141) were used to develop the in vitro cell culture model of glaucoma. To obtain a long-term delivery of DEX, pentablock (PB) copolymer was synthesize using the ring opening bulk …